Ablation of mitophagy receptor FUNDC1 accentuates septic cardiomyopathy through ACSL4-dependent regulation of ferroptosis and mitochondrial integrity

Sepsis evokes compromised myocardial function prompting heart failure albeit target therapy remains dismal. Our study examined the possible role of mitophagy receptor FUNDC1 in septic cardiomyopathy. A sepsis model was established using cecal ligation and puncture (CLP) in FUNDC1 knockout (FUNDC1−/−...

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Veröffentlicht in:	Free radical biology & medicine 2024-11, Vol.225, p.75-86
Hauptverfasser:	Li, Feng-Juan, Hu, Huantao, Wu, Liangyan, Luo, Bijun, Zhou, Yuan, Ren, Jun, Lin, Jie, Reiter, Russel J., Wang, Shuyi, Dong, Maolong, Guo, Jun, Peng, Hu
Format:	Artikel
Sprache:	eng
Schlagworte:	ACSL4 Animals Apoptosis Cardiomyopathies - etiology Cardiomyopathies - genetics Cardiomyopathies - metabolism Cardiomyopathies - pathology Cecal ligation and puncture Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Disease Models, Animal Female Ferroptosis Ferroptosis - genetics FUNDC1 Heart Humans Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - metabolism Mitochondria - pathology Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mitophagy Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Necroptosis Oxidative Stress Phospholipid Hydroperoxide Glutathione Peroxidase - genetics Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Sepsis - metabolism Sepsis - pathology
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