TDP-43 nuclear condensation and neurodegenerative proteinopathies

RNA-binding proteins (RBPs) can undergo phase separation and form condensates, processes that, in turn, can be critical for their functionality. In a recent study, Huang, Ellis, and colleagues show that cellular stress can trigger transient alterations in nuclear TAR DNA-binding protein 43 (TDP-43),...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2024-11, Vol.47 (11), p.849-850
Hauptverfasser:	Vassallu, Florencia, Igaz, Lionel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	amyotrophic lateral sclerosis Animals Cell Nucleus - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism frontotemporal dementia Humans membraneless organelles neurodegenerative disease Neurodegenerative Diseases - metabolism phase condensation RNA-binding protein TDP-43 Proteinopathies - genetics TDP-43 Proteinopathies - metabolism TDP-43 Proteinopathies - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!