Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model
Despite advancements in healthcare and increased lifespan, aging populations face numerous challenges, including declining cognitive function, increased susceptibility to chronic diseases, and reduced quality of life. This study investigated Aging impaired Locomotors and Biochemical Activities in Dr...
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| Veröffentlicht in: | Experimental gerontology 2024-11, Vol.197, p.112593, Article 112593 |
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| creator | Yusuf, Abdullateef Onoruoiza Danborno, Barnabas Bauchi, Zainab M. Sani, Dahiru Ndams, Iliya Shehu |
| description | Despite advancements in healthcare and increased lifespan, aging populations face numerous challenges, including declining cognitive function, increased susceptibility to chronic diseases, and reduced quality of life. This study investigated Aging impaired Locomotors and Biochemical Activities in Drosophila melanogaster Oregon R (Fruit Fly) Model with the aim to elucidate the mechanism involved. Adult wild-type Drosophila melanogaster Oregon R was used for this study. Survival assay, antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and malondialdehyde (MDA)) and total protein (TP) concentration were investigated. Data obtained were analyzed using R studio and GraphPad Prism. The result indicated low survival in male flies compared to female flies and the highest survival rate was observed with both flies reared together in the same vial. There was impaired locomotor activity in the flies with age. There was a significant decrease in the level of SOD, CAT, GSH and TP with age with a corresponding significant increase in the level of MDA. This finding demonstrated that locomotor activity decreased with aging with decrease performance index and also established the involvement of oxidation through the activities of antioxidant enzymes in aging; decreased (p |
| doi_str_mv | 10.1016/j.exger.2024.112593 |
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This study investigated Aging impaired Locomotors and Biochemical Activities in Drosophila melanogaster Oregon R (Fruit Fly) Model with the aim to elucidate the mechanism involved. Adult wild-type Drosophila melanogaster Oregon R was used for this study. Survival assay, antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and malondialdehyde (MDA)) and total protein (TP) concentration were investigated. Data obtained were analyzed using R studio and GraphPad Prism. The result indicated low survival in male flies compared to female flies and the highest survival rate was observed with both flies reared together in the same vial. There was impaired locomotor activity in the flies with age. There was a significant decrease in the level of SOD, CAT, GSH and TP with age with a corresponding significant increase in the level of MDA. This finding demonstrated that locomotor activity decreased with aging with decrease performance index and also established the involvement of oxidation through the activities of antioxidant enzymes in aging; decreased (p < 0.05) concentration of antioxidant enzymes and increased (p < 0.05) lipid peroxidation. Also, it demonstrated that female species had longer lifespan compared to males while co-habiting of male and female species extended lifespan.</description><identifier>ISSN: 0531-5565</identifier><identifier>ISSN: 1873-6815</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2024.112593</identifier><identifier>PMID: 39326807</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aging ; Aging - physiology ; Animals ; Antioxidant ; Antioxidants - metabolism ; Catalase - metabolism ; Drosophila melanogaster ; Drosophila melanogaster - physiology ; Female ; Glutathione - metabolism ; Lifespan ; Lipid Peroxidation ; Locomotion - physiology ; Locomotor ; Longevity - physiology ; Male ; Malondialdehyde - metabolism ; Models, Animal ; Oxidative Stress - physiology ; Superoxide Dismutase - metabolism ; Total protein</subject><ispartof>Experimental gerontology, 2024-11, Vol.197, p.112593, Article 112593</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-bf63ef78ac4400ff328a935113d372450a5bd95ec9225a21ac8f4c75969fcf733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0531556524002390$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39326807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yusuf, Abdullateef Onoruoiza</creatorcontrib><creatorcontrib>Danborno, Barnabas</creatorcontrib><creatorcontrib>Bauchi, Zainab M.</creatorcontrib><creatorcontrib>Sani, Dahiru</creatorcontrib><creatorcontrib>Ndams, Iliya Shehu</creatorcontrib><title>Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>Despite advancements in healthcare and increased lifespan, aging populations face numerous challenges, including declining cognitive function, increased susceptibility to chronic diseases, and reduced quality of life. This study investigated Aging impaired Locomotors and Biochemical Activities in Drosophila melanogaster Oregon R (Fruit Fly) Model with the aim to elucidate the mechanism involved. Adult wild-type Drosophila melanogaster Oregon R was used for this study. Survival assay, antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and malondialdehyde (MDA)) and total protein (TP) concentration were investigated. Data obtained were analyzed using R studio and GraphPad Prism. The result indicated low survival in male flies compared to female flies and the highest survival rate was observed with both flies reared together in the same vial. There was impaired locomotor activity in the flies with age. There was a significant decrease in the level of SOD, CAT, GSH and TP with age with a corresponding significant increase in the level of MDA. This finding demonstrated that locomotor activity decreased with aging with decrease performance index and also established the involvement of oxidation through the activities of antioxidant enzymes in aging; decreased (p < 0.05) concentration of antioxidant enzymes and increased (p < 0.05) lipid peroxidation. Also, it demonstrated that female species had longer lifespan compared to males while co-habiting of male and female species extended lifespan.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Antioxidant</subject><subject>Antioxidants - metabolism</subject><subject>Catalase - metabolism</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - physiology</subject><subject>Female</subject><subject>Glutathione - metabolism</subject><subject>Lifespan</subject><subject>Lipid Peroxidation</subject><subject>Locomotion - physiology</subject><subject>Locomotor</subject><subject>Longevity - physiology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Models, Animal</subject><subject>Oxidative Stress - physiology</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Total protein</subject><issn>0531-5565</issn><issn>1873-6815</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQhi0EgrI8ARLyEQ4pXuIsBw6IXUKqhOBsuc44TJXExU4RvD0uBY6c5vIv83-EHHM25YwX54spfLQQpoKJfMq5ULXcIhNelTIrKq62yYQpyTOlCrVH9mNcMMYKIfku2ZO1FEXFygnByxaHlmK_NBigoZ23vvejD9QMDZ2jt6_QozUdNXbEdxwRIsWBXgcf_fIVO0N76MzgWxNHCHQWoPUDfaKnLqxwpK77PKO9b6A7JDvOdBGOfu4Bebm9eb66zx5ndw9Xl4-ZFVU-ZnNXSHBlZWyeM-acFJWppeJcNrIUuWJGzZtaga2FUEZwYyuX21LVRe2sK6U8IKeb3GXwbyuIo-4xWujSk-BXUUvOWUquiypJ5UZq05oYwOllwN6ET82ZXjPWC_3NWK8Z6w3j5Dr5KVjNe2j-PL9Qk-BiI4A08x2TPVqEwUKTENtRNx7_LfgC8CuOww</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Yusuf, Abdullateef Onoruoiza</creator><creator>Danborno, Barnabas</creator><creator>Bauchi, Zainab M.</creator><creator>Sani, Dahiru</creator><creator>Ndams, Iliya Shehu</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202411</creationdate><title>Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model</title><author>Yusuf, Abdullateef Onoruoiza ; Danborno, Barnabas ; Bauchi, Zainab M. ; Sani, Dahiru ; Ndams, Iliya Shehu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-bf63ef78ac4400ff328a935113d372450a5bd95ec9225a21ac8f4c75969fcf733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Antioxidant</topic><topic>Antioxidants - metabolism</topic><topic>Catalase - metabolism</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - physiology</topic><topic>Female</topic><topic>Glutathione - metabolism</topic><topic>Lifespan</topic><topic>Lipid Peroxidation</topic><topic>Locomotion - physiology</topic><topic>Locomotor</topic><topic>Longevity - physiology</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Models, Animal</topic><topic>Oxidative Stress - physiology</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Total protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yusuf, Abdullateef Onoruoiza</creatorcontrib><creatorcontrib>Danborno, Barnabas</creatorcontrib><creatorcontrib>Bauchi, Zainab M.</creatorcontrib><creatorcontrib>Sani, Dahiru</creatorcontrib><creatorcontrib>Ndams, Iliya Shehu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yusuf, Abdullateef Onoruoiza</au><au>Danborno, Barnabas</au><au>Bauchi, Zainab M.</au><au>Sani, Dahiru</au><au>Ndams, Iliya Shehu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>197</volume><spage>112593</spage><pages>112593-</pages><artnum>112593</artnum><issn>0531-5565</issn><issn>1873-6815</issn><eissn>1873-6815</eissn><abstract>Despite advancements in healthcare and increased lifespan, aging populations face numerous challenges, including declining cognitive function, increased susceptibility to chronic diseases, and reduced quality of life. This study investigated Aging impaired Locomotors and Biochemical Activities in Drosophila melanogaster Oregon R (Fruit Fly) Model with the aim to elucidate the mechanism involved. Adult wild-type Drosophila melanogaster Oregon R was used for this study. Survival assay, antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and malondialdehyde (MDA)) and total protein (TP) concentration were investigated. Data obtained were analyzed using R studio and GraphPad Prism. The result indicated low survival in male flies compared to female flies and the highest survival rate was observed with both flies reared together in the same vial. There was impaired locomotor activity in the flies with age. There was a significant decrease in the level of SOD, CAT, GSH and TP with age with a corresponding significant increase in the level of MDA. This finding demonstrated that locomotor activity decreased with aging with decrease performance index and also established the involvement of oxidation through the activities of antioxidant enzymes in aging; decreased (p < 0.05) concentration of antioxidant enzymes and increased (p < 0.05) lipid peroxidation. Also, it demonstrated that female species had longer lifespan compared to males while co-habiting of male and female species extended lifespan.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>39326807</pmid><doi>10.1016/j.exger.2024.112593</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Aging - physiology Animals Antioxidant Antioxidants - metabolism Catalase - metabolism Drosophila melanogaster Drosophila melanogaster - physiology Female Glutathione - metabolism Lifespan Lipid Peroxidation Locomotion - physiology Locomotor Longevity - physiology Male Malondialdehyde - metabolism Models, Animal Oxidative Stress - physiology Superoxide Dismutase - metabolism Total protein |
| title | Aging impaired locomotor and biochemical activities in Drosophila melanogaster Oregon R (fruit fly) model |
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