MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice
The apoptosis resistance of myofibroblasts is a hallmark in the irreversible progression of pulmonary fibrosis (PF). While the underlying molecular mechanism remains elusive. In this study, we unveiled a previously unrecognized mechanism underlying myofibroblast apoptosis resistance during PF. Our i...
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| Veröffentlicht in: | Journal of cellular physiology 2024-12, Vol.239 (12), p.e31442-n/a |
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| creator | Jin, Ling Bao, Bo Huang, Xiao‐Ting Tao, Jia‐Hao Duan, Jia‐Xi Zhong, Wen‐Jin Zhang, Chen‐Yu Liu, Yu‐Biao Chen, Hui Yang, Nan‐Shi‐Yu Guan, Cha‐Xiang Zhou, Yong |
| description | The apoptosis resistance of myofibroblasts is a hallmark in the irreversible progression of pulmonary fibrosis (PF). While the underlying molecular mechanism remains elusive. In this study, we unveiled a previously unrecognized mechanism underlying myofibroblast apoptosis resistance during PF. Our investigation revealed heightened expression of mesenchyme homeobox 1 (MEOX1) in the lungs of idiopathic pulmonary fibrosis (IPF) patients and bleomycin‐induced PF mice. Silencing MEOX1 significantly attenuated PF progression in mice. In vitro, we found a notable increase in MEOX1 expression in transforming growth factor‐β1 (TGF‐β1)‐induced myofibroblasts. Silencing MEOX1 enhanced apoptosis of myofibroblasts. Mechanistically, we identified G‐protein signaling pathway regulatory factor 4 (RGS4) as a critical downstream target of MEOX1, as predicted by bioinformatics analysis. MEOX1 enhanced apoptosis resistance by upregulating RGS4 expression in myofibroblasts. In conclusion, our study highlights MEOX1 as a promising therapeutic target for protecting against PF by modulating myofibroblast apoptosis resistance.
Schematic representation of the proposed mechanisms for MEOX1‐induced resistance to apoptosis in myofibroblasts during PF. MEOX1 induces apoptosis resistance in myofibroblasts by increasing RGS4 expression, contributing to the development of PF. |
| doi_str_mv | 10.1002/jcp.31442 |
| format | Article |
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Schematic representation of the proposed mechanisms for MEOX1‐induced resistance to apoptosis in myofibroblasts during PF. MEOX1 induces apoptosis resistance in myofibroblasts by increasing RGS4 expression, contributing to the development of PF.</description><identifier>ISSN: 0021-9541</identifier><identifier>ISSN: 1097-4652</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.31442</identifier><identifier>PMID: 39319990</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Apoptosis ; apoptosis resistance ; Bioinformatics ; Bleomycin ; Bleomycin - toxicity ; Disease Models, Animal ; Fibrosis ; Growth factors ; Homeobox ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Humans ; Idiopathic Pulmonary Fibrosis - chemically induced ; Idiopathic Pulmonary Fibrosis - genetics ; Idiopathic Pulmonary Fibrosis - metabolism ; Idiopathic Pulmonary Fibrosis - pathology ; Lung - metabolism ; Lung - pathology ; Lung diseases ; Male ; Mesenchyme ; mesenchyme homeobox 1 ; Mice ; Mice, Inbred C57BL ; Molecular modelling ; myofibroblasts ; Myofibroblasts - metabolism ; Myofibroblasts - pathology ; pulmonary fibrosis ; Pulmonary Fibrosis - chemically induced ; Pulmonary Fibrosis - genetics ; Pulmonary Fibrosis - metabolism ; Pulmonary Fibrosis - pathology ; RGS Proteins - genetics ; RGS Proteins - metabolism ; Signal Transduction ; Therapeutic targets ; Transforming Growth Factor beta1 - genetics ; Transforming Growth Factor beta1 - metabolism</subject><ispartof>Journal of cellular physiology, 2024-12, Vol.239 (12), p.e31442-n/a</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2432-d016c496fd50365d35f4d9ef4b282bc41e9751a2f80044760634a338d1fdc1543</cites><orcidid>0000-0002-8505-8724 ; 0000-0002-7348-2376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.31442$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.31442$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39319990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Ling</creatorcontrib><creatorcontrib>Bao, Bo</creatorcontrib><creatorcontrib>Huang, Xiao‐Ting</creatorcontrib><creatorcontrib>Tao, Jia‐Hao</creatorcontrib><creatorcontrib>Duan, Jia‐Xi</creatorcontrib><creatorcontrib>Zhong, Wen‐Jin</creatorcontrib><creatorcontrib>Zhang, Chen‐Yu</creatorcontrib><creatorcontrib>Liu, Yu‐Biao</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Yang, Nan‐Shi‐Yu</creatorcontrib><creatorcontrib>Guan, Cha‐Xiang</creatorcontrib><creatorcontrib>Zhou, Yong</creatorcontrib><title>MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>The apoptosis resistance of myofibroblasts is a hallmark in the irreversible progression of pulmonary fibrosis (PF). While the underlying molecular mechanism remains elusive. In this study, we unveiled a previously unrecognized mechanism underlying myofibroblast apoptosis resistance during PF. Our investigation revealed heightened expression of mesenchyme homeobox 1 (MEOX1) in the lungs of idiopathic pulmonary fibrosis (IPF) patients and bleomycin‐induced PF mice. Silencing MEOX1 significantly attenuated PF progression in mice. In vitro, we found a notable increase in MEOX1 expression in transforming growth factor‐β1 (TGF‐β1)‐induced myofibroblasts. Silencing MEOX1 enhanced apoptosis of myofibroblasts. Mechanistically, we identified G‐protein signaling pathway regulatory factor 4 (RGS4) as a critical downstream target of MEOX1, as predicted by bioinformatics analysis. MEOX1 enhanced apoptosis resistance by upregulating RGS4 expression in myofibroblasts. In conclusion, our study highlights MEOX1 as a promising therapeutic target for protecting against PF by modulating myofibroblast apoptosis resistance.
Schematic representation of the proposed mechanisms for MEOX1‐induced resistance to apoptosis in myofibroblasts during PF. MEOX1 induces apoptosis resistance in myofibroblasts by increasing RGS4 expression, contributing to the development of PF.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>apoptosis resistance</subject><subject>Bioinformatics</subject><subject>Bleomycin</subject><subject>Bleomycin - toxicity</subject><subject>Disease Models, Animal</subject><subject>Fibrosis</subject><subject>Growth factors</subject><subject>Homeobox</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis - chemically induced</subject><subject>Idiopathic Pulmonary Fibrosis - genetics</subject><subject>Idiopathic Pulmonary Fibrosis - metabolism</subject><subject>Idiopathic Pulmonary Fibrosis - pathology</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Mesenchyme</subject><subject>mesenchyme homeobox 1</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular modelling</subject><subject>myofibroblasts</subject><subject>Myofibroblasts - metabolism</subject><subject>Myofibroblasts - pathology</subject><subject>pulmonary fibrosis</subject><subject>Pulmonary Fibrosis - chemically induced</subject><subject>Pulmonary Fibrosis - genetics</subject><subject>Pulmonary Fibrosis - metabolism</subject><subject>Pulmonary Fibrosis - pathology</subject><subject>RGS Proteins - genetics</subject><subject>RGS Proteins - metabolism</subject><subject>Signal Transduction</subject><subject>Therapeutic targets</subject><subject>Transforming Growth Factor beta1 - genetics</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><issn>0021-9541</issn><issn>1097-4652</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAcBvAgipvTg19AAl4U7Ja3tstRxnxjMg8KXqSkaTIy2qYmLbJvb7ZOD4KX5JBfnuT_AHCO0RgjRCZr2YwpZowcgCFGPI1YEpNDMAxnOOIxwwNw4v0aIcQ5pcdgQDnFnHM0BB_P8-U7hq0zq5VyHlYbq03ubF4K30LR2Ka13njoVFhbUUt1A6Wtg8-71tQr2FrYdGVla-E2cHd1y00NKyPVKTjSovTqbL-PwNvd_HX2EC2W94-z20UkCaMkKhBOJOOJLmJEk7igsWYFV5rlZEpyybDiaYwF0VOEGEsTlFAmKJ0WWBcSx4yOwFWf2zj72SnfZpXxUpWlqJXtfEZDK-EhTKeBXv6ha9u5OvwuKBaTNDAU1HWvZJjHO6WzxpkqjJhhlG07z0Ln2a7zYC_2iV1eqeJX_pQcwKQHX6ZUm_-TsqfZSx_5DejMijk</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Jin, Ling</creator><creator>Bao, Bo</creator><creator>Huang, Xiao‐Ting</creator><creator>Tao, Jia‐Hao</creator><creator>Duan, Jia‐Xi</creator><creator>Zhong, Wen‐Jin</creator><creator>Zhang, Chen‐Yu</creator><creator>Liu, Yu‐Biao</creator><creator>Chen, Hui</creator><creator>Yang, Nan‐Shi‐Yu</creator><creator>Guan, Cha‐Xiang</creator><creator>Zhou, Yong</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8505-8724</orcidid><orcidid>https://orcid.org/0000-0002-7348-2376</orcidid></search><sort><creationdate>202412</creationdate><title>MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice</title><author>Jin, Ling ; Bao, Bo ; Huang, Xiao‐Ting ; Tao, Jia‐Hao ; Duan, Jia‐Xi ; Zhong, Wen‐Jin ; Zhang, Chen‐Yu ; Liu, Yu‐Biao ; Chen, Hui ; Yang, Nan‐Shi‐Yu ; Guan, Cha‐Xiang ; Zhou, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2432-d016c496fd50365d35f4d9ef4b282bc41e9751a2f80044760634a338d1fdc1543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>apoptosis resistance</topic><topic>Bioinformatics</topic><topic>Bleomycin</topic><topic>Bleomycin - toxicity</topic><topic>Disease Models, Animal</topic><topic>Fibrosis</topic><topic>Growth factors</topic><topic>Homeobox</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Humans</topic><topic>Idiopathic Pulmonary Fibrosis - chemically induced</topic><topic>Idiopathic Pulmonary Fibrosis - genetics</topic><topic>Idiopathic Pulmonary Fibrosis - metabolism</topic><topic>Idiopathic Pulmonary Fibrosis - pathology</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Mesenchyme</topic><topic>mesenchyme homeobox 1</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular modelling</topic><topic>myofibroblasts</topic><topic>Myofibroblasts - metabolism</topic><topic>Myofibroblasts - pathology</topic><topic>pulmonary fibrosis</topic><topic>Pulmonary Fibrosis - chemically induced</topic><topic>Pulmonary Fibrosis - genetics</topic><topic>Pulmonary Fibrosis - metabolism</topic><topic>Pulmonary Fibrosis - pathology</topic><topic>RGS Proteins - genetics</topic><topic>RGS Proteins - metabolism</topic><topic>Signal Transduction</topic><topic>Therapeutic targets</topic><topic>Transforming Growth Factor beta1 - genetics</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Ling</creatorcontrib><creatorcontrib>Bao, Bo</creatorcontrib><creatorcontrib>Huang, Xiao‐Ting</creatorcontrib><creatorcontrib>Tao, Jia‐Hao</creatorcontrib><creatorcontrib>Duan, Jia‐Xi</creatorcontrib><creatorcontrib>Zhong, Wen‐Jin</creatorcontrib><creatorcontrib>Zhang, Chen‐Yu</creatorcontrib><creatorcontrib>Liu, Yu‐Biao</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Yang, Nan‐Shi‐Yu</creatorcontrib><creatorcontrib>Guan, Cha‐Xiang</creatorcontrib><creatorcontrib>Zhou, Yong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Ling</au><au>Bao, Bo</au><au>Huang, Xiao‐Ting</au><au>Tao, Jia‐Hao</au><au>Duan, Jia‐Xi</au><au>Zhong, Wen‐Jin</au><au>Zhang, Chen‐Yu</au><au>Liu, Yu‐Biao</au><au>Chen, Hui</au><au>Yang, Nan‐Shi‐Yu</au><au>Guan, Cha‐Xiang</au><au>Zhou, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>239</volume><issue>12</issue><spage>e31442</spage><epage>n/a</epage><pages>e31442-n/a</pages><issn>0021-9541</issn><issn>1097-4652</issn><eissn>1097-4652</eissn><abstract>The apoptosis resistance of myofibroblasts is a hallmark in the irreversible progression of pulmonary fibrosis (PF). While the underlying molecular mechanism remains elusive. In this study, we unveiled a previously unrecognized mechanism underlying myofibroblast apoptosis resistance during PF. Our investigation revealed heightened expression of mesenchyme homeobox 1 (MEOX1) in the lungs of idiopathic pulmonary fibrosis (IPF) patients and bleomycin‐induced PF mice. Silencing MEOX1 significantly attenuated PF progression in mice. In vitro, we found a notable increase in MEOX1 expression in transforming growth factor‐β1 (TGF‐β1)‐induced myofibroblasts. Silencing MEOX1 enhanced apoptosis of myofibroblasts. Mechanistically, we identified G‐protein signaling pathway regulatory factor 4 (RGS4) as a critical downstream target of MEOX1, as predicted by bioinformatics analysis. MEOX1 enhanced apoptosis resistance by upregulating RGS4 expression in myofibroblasts. In conclusion, our study highlights MEOX1 as a promising therapeutic target for protecting against PF by modulating myofibroblast apoptosis resistance.
Schematic representation of the proposed mechanisms for MEOX1‐induced resistance to apoptosis in myofibroblasts during PF. MEOX1 induces apoptosis resistance in myofibroblasts by increasing RGS4 expression, contributing to the development of PF.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39319990</pmid><doi>10.1002/jcp.31442</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-8505-8724</orcidid><orcidid>https://orcid.org/0000-0002-7348-2376</orcidid></addata></record> |
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| subjects | Animals Apoptosis apoptosis resistance Bioinformatics Bleomycin Bleomycin - toxicity Disease Models, Animal Fibrosis Growth factors Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Idiopathic Pulmonary Fibrosis - chemically induced Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Lung - metabolism Lung - pathology Lung diseases Male Mesenchyme mesenchyme homeobox 1 Mice Mice, Inbred C57BL Molecular modelling myofibroblasts Myofibroblasts - metabolism Myofibroblasts - pathology pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology RGS Proteins - genetics RGS Proteins - metabolism Signal Transduction Therapeutic targets Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism |
| title | MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice |
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