Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence

Beta (β)-cell senescence contributes to type 2 diabetes mellitus (T2DM). While exercise is vital for T2DM management and significantly affects cellular ageing markers, its effect on β-cell senescence remains unexplored. Here, we show that short-term endurance exercise training (treadmill running, 1 ...

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Veröffentlicht in:	Nature metabolism 2024-10, Vol.6 (10), p.1976-1990
Hauptverfasser:	Carapeto, Priscila, Iwasaki, Kanako, Hela, Francesko, Kahng, Jiho, Alves-Wagner, Ana B., Middelbeek, Roeland J. W., Hirshman, Michael F., Rutter, Guy A., Goodyear, Laurie J., Aguayo-Mazzucato, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319 631/80/509 631/80/86 AMP-Activated Protein Kinases - metabolism Animals Biomedical and Life Sciences Cellular Senescence Diabetes Mellitus, Type 2 - metabolism Enzyme Activation Female Glucagon - blood Glucagon - metabolism Humans Insulin Resistance Insulin-Secreting Cells - metabolism Islets of Langerhans - metabolism Life Sciences Male Mice NF-E2-Related Factor 2 - metabolism Physical Conditioning, Animal Signal Transduction
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