Functional redundancy between glucocorticoid and mineralocorticoid receptors in mature corticotropin‐releasing hormone neurons protects from obesity

Objective Here, we aimed to investigate the role of glucocorticoid and mineralocorticoid receptors (GRs and MRs, respectively) in the regulation of energy homeostasis. Methods We used three mouse models with simultaneous deletion of GRs and MRs in either forebrain neurons, the paraventricular nucleu...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2024-10, Vol.32 (10), p.1885-1896
Hauptverfasser:	Liu, Yu, Lin, Dongfa, Najam, Syeda Sadia, Huang, Shangyuan, Song, Muyi, Sirakawin, Chaweewan, Zhao, Catherine, Jiang, Haixia, Konopka, Witold, Herzig, Stephan, Vinnikov, Ilya A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Corticosterone - blood Corticosterone - metabolism Corticotropin-Releasing Hormone - metabolism Energy Energy Metabolism Enzymes Female Food Glucose Homeostasis Insulin Resistance Kinases Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Neurons - metabolism Obesity Obesity - metabolism Paraventricular Hypothalamic Nucleus - metabolism Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Signal transduction Software Statistical analysis
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