Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC

The master regulator transcription factor MYC is implicated in numerous human cancers, and its targeting is a long‐standing challenge in drug development. MYC is a typical ‘undruggable’ target, with no binding pockets on its DNA binding domain and extensive intrinsically disordered regions. Rather t...

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Veröffentlicht in:	Angewandte Chemie International Edition 2025-01, Vol.64 (4), p.e202416082-n/a
Hauptverfasser:	Ellenbroek, Brecht D., Kahler, Jan Pascal, Arella, Damiano, Lin, Cherina, Jespers, Willem, Züger, Eliane Ann‐Katrin, Drukker, Micha, Pomplun, Sebastian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA - metabolism Humans Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism
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