Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platform

With current plans for manned missions to Mars and beyond, the need to better understand, prevent, and counteract the harmful effects of long-duration spaceflight on the body is becoming increasingly important. In this study, an automated heart-on-a-chip platform was flown to the International Space...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-10, Vol.121 (40), p.e2404644121
Hauptverfasser:	Mair, Devin B, Tsui, Jonathan H, Higashi, Ty, Koenig, Paul, Dong, Zhipeng, Chen, Jeffrey F, Meir, Jessica U, Smith, Alec S T, Lee, Peter H U, Ahn, Eun Hyun, Countryman, Stefanie, Sniadecki, Nathan J, Kim, Deok-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrhythmia Automation Calcium (mitochondrial) Calcium signalling Cardiomyocytes Congestive heart failure Gene regulation Gene sequencing Genes Heart Heart diseases Humans Impact analysis International Space Station Lab-On-A-Chip Devices Long duration space flight Manned Mars missions Metabolic disorders Microgravity Mitochondria Mitochondria - metabolism Mitochondria, Heart - metabolism Muscle contraction Myocardial Contraction - physiology Myocytes, Cardiac - metabolism Oxidative Stress Real time Return to Earth space flight Ribonucleic acid RNA Space flight Space Flight - methods Transcriptomics Weightlessness - adverse effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!