SON is an essential RNA splicing factor promoting ErbB2 and ErbB3 expression in breast cancer

Background In breast cancer, ErbB receptors play a critical role, and overcoming drug resistance remains a major challenge in the clinic. However, intricate regulatory mechanisms of ErbB family genes are poorly understood. Here, we demonstrate SON as an ErbB-regulatory splicing factor and a novel th...

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Veröffentlicht in:	British journal of cancer 2024-11, Vol.131 (9), p.1437-1449
Hauptverfasser:	Phillips, Joshua B., Park, Seong-Sik, Lin, Cheng-Han, Cho, Juyoung, Lim, Sangbin, Aurora, Ritu, Kim, Jin-Hwan, Angajala, Anusha, Park, Bohye, Stone, Joshua K., Wang, Bin, Kahn, Andrea G., Lim, Ssang-Taek Steve, Kim, Jung-Hyun, Ahn, Eun-Young Erin, Tan, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1645/1792 631/67/1347 AKT protein Animals Apoptosis Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Cell Line, Tumor Cell Proliferation Drug Resistance Epidemiology Epidermal growth factor ErbB protein ErbB-2 protein ErbB-3 protein Female Gene expression Gene Expression Regulation, Neoplastic Humans Immunoprecipitation Kinases Mice Molecular Medicine Oncology Phosphorylation Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - genetics Receptor, ErbB-3 - metabolism Ribonucleic acid RNA RNA Splicing RNA Splicing Factors - genetics RNA Splicing Factors - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism RNA-mediated interference Signal Transduction Splicing factors Targeted cancer therapy Therapeutic targets Tumor cell lines Tumors
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