Correlational assessment of the effects of JM-20 in a rat model of parkinsonism

We previously demonstrated that JM-20, a molecule with neuroactive functions, protects rats against rotenone and 6-hydroxydopamine (6-OHDA) neurotoxicity. In addition, we demonstrated that JM-20 inhibits the aggregation and cytotoxicity of alpha-synuclein in vitro. In this study, we performed correl...

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Veröffentlicht in:	Behavioural brain research 2025-01, Vol.476, p.115269, Article 115269
Hauptverfasser:	Fonseca-Fonseca, Luis Arturo, Fuentes, Nancy Pavón, Sánchez, Jeney Ramírez, Iglesias, Ángela Tuero, Outeiro, Tiago Fleming, Silva, Víctor Diogenes Amaral da, Costa, Silvia Lima, Núñez-Figueredo, Yanier
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Animals Benzodiazepines Disease Models, Animal Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Dose-Response Relationship, Drug JM-20 Male Mitochondria - drug effects Mitochondria - metabolism Motor Activity - drug effects Neuroprotection Neuroprotective Agents - pharmacology Niacin - analogs & derivatives Oxidative stress Oxidopamine - pharmacology Parkinsonian Disorders - chemically induced Parkinsonian Disorders - drug therapy Parkinsonian Disorders - pathology Parkinsonian Disorders - physiopathology Parkinson’s disease Rats Rats, Wistar Rotenone Rotenone - pharmacology
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