Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy

Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy

Introduction Describe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy. Methods Observational study in which categorized patients according to those with and without parametrial involv...

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Veröffentlicht in:International journal of surgical pathology 2024-10, Vol.32 (7), p.1241-1247
Hauptverfasser: Barquet-Muñoz, Salim, Bandala-Jaques, Antonio, Perez-Montiel, Ma Delia, Prada, Diddier, Martínez-Flores, Marithe, Salcedo-Hernández, Rosa A., Pérez-Plasencia, Carlos, Gonzalez-Enciso, Aaron, Leon, David Cantu-de
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Endometrial cancer
Hysterectomy
Medical prognosis
Metastasis
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container_issue 7
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container_title International journal of surgical pathology
container_volume 32
creator Barquet-Muñoz, Salim
Bandala-Jaques, Antonio
Perez-Montiel, Ma Delia
Prada, Diddier
Martínez-Flores, Marithe
Salcedo-Hernández, Rosa A.
Pérez-Plasencia, Carlos
Gonzalez-Enciso, Aaron
Leon, David Cantu-de
description Introduction Describe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy. Methods Observational study in which categorized patients according to those with and without parametrial involvement. A descriptive analysis and comparative analysis were performed for associations between parametrial spread and clinical, surgical, and pathology variables. Results We analyzed 85 patients, which 18 (21%) had parametrial involvement. Pathology factors associated with parametrial involvement were the endometrioid subtype, grade 3, and variants of poor prognosis (odds ratio (OR) 3.41, 95% CI 1.09-10.64; P = 0.035), myometrial invasion of over 50% (OR 7.76, 95% CI 1.65-36.44; P = 0.009), serosal involvement (OR 17.07, 95% CI 3.87-75.35; P 
doi_str_mv 10.1177/10668969231225773
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Methods Observational study in which categorized patients according to those with and without parametrial involvement. A descriptive analysis and comparative analysis were performed for associations between parametrial spread and clinical, surgical, and pathology variables. Results We analyzed 85 patients, which 18 (21%) had parametrial involvement. Pathology factors associated with parametrial involvement were the endometrioid subtype, grade 3, and variants of poor prognosis (odds ratio (OR) 3.41, 95% CI 1.09-10.64; P = 0.035), myometrial invasion of over 50% (OR 7.76, 95% CI 1.65-36.44; P = 0.009), serosal involvement (OR 17.07, 95% CI 3.87-75.35; P &lt; 0.001), ovarian metastasis (OR 5.15, 95% CI 1.36-19.46; P = 0.016), positive peritoneal cytology (OR 3.9, 95% CI 1.04-14.77; P = 0.044), and lymph node metastasis (OR 3.4; 95% CI 1.16-9.97; P = 0.026). Five-year disease-free survival was 74% (95% CI 57.4-85.4) for the group without parametrial spread and 50.8% (95% CI 22.7-73.4) for the group with parametrial spread (P = 0.001). Similarly, 5-year overall survival was 85.2% (95% CI 67.9-93.6) for the group without parametrial spread and 47.5% (95% CI 8.1-80.2) for the group with parametrial spread (P = 0.002). Conclusion Factors associated with parametrial involvement were histologies of poor prognosis, tumors affecting uterine serosa, cervix, or spread beyond the uterus. Additionally, parametrial involvement directly affects prognosis by reducing overall survival, disease-free survival and increasing odds for recurrence.</description><identifier>ISSN: 1066-8969</identifier><identifier>ISSN: 1940-2465</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/10668969231225773</identifier><identifier>PMID: 38389391</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Endometrial cancer ; Hysterectomy ; Medical prognosis ; Metastasis</subject><ispartof>International journal of surgical pathology, 2024-10, Vol.32 (7), p.1241-1247</ispartof><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c320t-9e09ab270cdd762223fcfc542f73dbddbab8335e1aca845d1457f2bbf27a6da63</cites><orcidid>0000-0002-0229-7931</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/10668969231225773$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/10668969231225773$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21820,27925,27926,43622,43623</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38389391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barquet-Muñoz, Salim</creatorcontrib><creatorcontrib>Bandala-Jaques, Antonio</creatorcontrib><creatorcontrib>Perez-Montiel, Ma Delia</creatorcontrib><creatorcontrib>Prada, Diddier</creatorcontrib><creatorcontrib>Martínez-Flores, Marithe</creatorcontrib><creatorcontrib>Salcedo-Hernández, Rosa A.</creatorcontrib><creatorcontrib>Pérez-Plasencia, Carlos</creatorcontrib><creatorcontrib>Gonzalez-Enciso, Aaron</creatorcontrib><creatorcontrib>Leon, David Cantu-de</creatorcontrib><title>Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>Introduction Describe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy. Methods Observational study in which categorized patients according to those with and without parametrial involvement. A descriptive analysis and comparative analysis were performed for associations between parametrial spread and clinical, surgical, and pathology variables. Results We analyzed 85 patients, which 18 (21%) had parametrial involvement. Pathology factors associated with parametrial involvement were the endometrioid subtype, grade 3, and variants of poor prognosis (odds ratio (OR) 3.41, 95% CI 1.09-10.64; P = 0.035), myometrial invasion of over 50% (OR 7.76, 95% CI 1.65-36.44; P = 0.009), serosal involvement (OR 17.07, 95% CI 3.87-75.35; P &lt; 0.001), ovarian metastasis (OR 5.15, 95% CI 1.36-19.46; P = 0.016), positive peritoneal cytology (OR 3.9, 95% CI 1.04-14.77; P = 0.044), and lymph node metastasis (OR 3.4; 95% CI 1.16-9.97; P = 0.026). Five-year disease-free survival was 74% (95% CI 57.4-85.4) for the group without parametrial spread and 50.8% (95% CI 22.7-73.4) for the group with parametrial spread (P = 0.001). Similarly, 5-year overall survival was 85.2% (95% CI 67.9-93.6) for the group without parametrial spread and 47.5% (95% CI 8.1-80.2) for the group with parametrial spread (P = 0.002). Conclusion Factors associated with parametrial involvement were histologies of poor prognosis, tumors affecting uterine serosa, cervix, or spread beyond the uterus. Additionally, parametrial involvement directly affects prognosis by reducing overall survival, disease-free survival and increasing odds for recurrence.</description><subject>Endometrial cancer</subject><subject>Hysterectomy</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><issn>1066-8969</issn><issn>1940-2465</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp10d9LwzAQB_AgipvTP8AXKfjiSzU_2qR9lLGpIDhEn8s1STWjbTRJJ_vvzdhUUHxK4D73vYND6JTgS0KEuCKY86LkJWWE0lwItofGpMxwSjOe78d_rKcbMEJH3i8xxpRTcohGrGBFyUoyRqs5yGCdT669t9JA0Cr5MOE1WYCDTgdnoE3u-pVtV7rTfUhMn8x6Zb9KU3DS9LaDTWEBwUTjkyenf5IeQRkZ6e3aB-10HNetj9FBA63XJ7t3gp7ns6fpbXr_cHM3vb5PJaM4pKXGJdRUYKmU4JRS1shG5hltBFO1UjXUBWO5JiChyHJFslw0tK4bKoAr4GyCLra5b86-D9qHqjNe6raFXtvBV4zgQnAssizS8190aQfXx-2iIpEInOdRka2SznrvdFO9OdOBW1cEV5ujVH-OEnvOdslD3Wn13fF1hQgut8DDi_4Z-3_iJ-vtlhw</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Barquet-Muñoz, Salim</creator><creator>Bandala-Jaques, Antonio</creator><creator>Perez-Montiel, Ma Delia</creator><creator>Prada, Diddier</creator><creator>Martínez-Flores, Marithe</creator><creator>Salcedo-Hernández, Rosa A.</creator><creator>Pérez-Plasencia, Carlos</creator><creator>Gonzalez-Enciso, Aaron</creator><creator>Leon, David Cantu-de</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0229-7931</orcidid></search><sort><creationdate>20241001</creationdate><title>Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy</title><author>Barquet-Muñoz, Salim ; Bandala-Jaques, Antonio ; Perez-Montiel, Ma Delia ; Prada, Diddier ; Martínez-Flores, Marithe ; Salcedo-Hernández, Rosa A. ; Pérez-Plasencia, Carlos ; Gonzalez-Enciso, Aaron ; Leon, David Cantu-de</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-9e09ab270cdd762223fcfc542f73dbddbab8335e1aca845d1457f2bbf27a6da63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Endometrial cancer</topic><topic>Hysterectomy</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barquet-Muñoz, Salim</creatorcontrib><creatorcontrib>Bandala-Jaques, Antonio</creatorcontrib><creatorcontrib>Perez-Montiel, Ma Delia</creatorcontrib><creatorcontrib>Prada, Diddier</creatorcontrib><creatorcontrib>Martínez-Flores, Marithe</creatorcontrib><creatorcontrib>Salcedo-Hernández, Rosa A.</creatorcontrib><creatorcontrib>Pérez-Plasencia, Carlos</creatorcontrib><creatorcontrib>Gonzalez-Enciso, Aaron</creatorcontrib><creatorcontrib>Leon, David Cantu-de</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barquet-Muñoz, Salim</au><au>Bandala-Jaques, Antonio</au><au>Perez-Montiel, Ma Delia</au><au>Prada, Diddier</au><au>Martínez-Flores, Marithe</au><au>Salcedo-Hernández, Rosa A.</au><au>Pérez-Plasencia, Carlos</au><au>Gonzalez-Enciso, Aaron</au><au>Leon, David Cantu-de</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>32</volume><issue>7</issue><spage>1241</spage><epage>1247</epage><pages>1241-1247</pages><issn>1066-8969</issn><issn>1940-2465</issn><eissn>1940-2465</eissn><abstract>Introduction Describe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy. Methods Observational study in which categorized patients according to those with and without parametrial involvement. A descriptive analysis and comparative analysis were performed for associations between parametrial spread and clinical, surgical, and pathology variables. Results We analyzed 85 patients, which 18 (21%) had parametrial involvement. Pathology factors associated with parametrial involvement were the endometrioid subtype, grade 3, and variants of poor prognosis (odds ratio (OR) 3.41, 95% CI 1.09-10.64; P = 0.035), myometrial invasion of over 50% (OR 7.76, 95% CI 1.65-36.44; P = 0.009), serosal involvement (OR 17.07, 95% CI 3.87-75.35; P &lt; 0.001), ovarian metastasis (OR 5.15, 95% CI 1.36-19.46; P = 0.016), positive peritoneal cytology (OR 3.9, 95% CI 1.04-14.77; P = 0.044), and lymph node metastasis (OR 3.4; 95% CI 1.16-9.97; P = 0.026). Five-year disease-free survival was 74% (95% CI 57.4-85.4) for the group without parametrial spread and 50.8% (95% CI 22.7-73.4) for the group with parametrial spread (P = 0.001). Similarly, 5-year overall survival was 85.2% (95% CI 67.9-93.6) for the group without parametrial spread and 47.5% (95% CI 8.1-80.2) for the group with parametrial spread (P = 0.002). Conclusion Factors associated with parametrial involvement were histologies of poor prognosis, tumors affecting uterine serosa, cervix, or spread beyond the uterus. Additionally, parametrial involvement directly affects prognosis by reducing overall survival, disease-free survival and increasing odds for recurrence.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>38389391</pmid><doi>10.1177/10668969231225773</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0229-7931</orcidid></addata></record>
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subjects Endometrial cancer
Hysterectomy
Medical prognosis
Metastasis
title Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy
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