Leptin reduces LPS‐induced A1 reactive astrocyte activation and inflammation via inhibiting p38‐MAPK signaling pathway

Neurotoxic A1 reactive astrocytes are induced by inflammatory stimuli. Leptin has been confirmed to have neuroprotective properties. However, its effect on the activation of A1 astrocytes in infectious inflammation is unclear. In the current study, astrocytes cultured from postnatal day 1 Sprague–Da...

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Veröffentlicht in:	Glia 2025-01, Vol.73 (1), p.25-37
Hauptverfasser:	Sun, Meiqi, Song, Yiqun, Hu, Xiaoxuan, Zhang, Zixuan, Tan, Ruolan, Cai, Zhenlu, Wang, Xinyi, Fu, Yali, You, Hongli, Cui, Simeng, Zhao, Wanting, An, Jing, Chen, Xinlin, Lu, Haixia
Format:	Artikel
Sprache:	eng
Schlagworte:	A1 reactive astrocyte Animal models Animals Animals, Newborn Astrocytes Astrocytes - drug effects Astrocytes - metabolism Cells, Cultured Cytokines Cytokines - metabolism Gene expression In vivo methods and tests Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammatory response Leptin Leptin - metabolism Leptin - pharmacology lipopolysaccharide Lipopolysaccharides Lipopolysaccharides - pharmacology MAP kinase MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology neuroinflammation Neuroprotection Neurotoxicity p38 Mitogen-Activated Protein Kinases - metabolism Phosphors Pp65 protein p‐38 MAPK pathway Rats Rats, Sprague-Dawley Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Transcription activation
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