Depression and stigma among a sample of Egyptian adolescents with epilepsy and their impact on antiseizure medications adherence
•Depression and self-stigma are significant barriers to adherence among adolescents with epilepsy.•Patients with adolescent-onset epilepsy were significantly more adherent to their ASMs compared to those with childhood-onset epilepsy.•The adherent group had significantly lower scores on KSSE and PHQ...
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| Veröffentlicht in: | Epilepsy & behavior 2024-12, Vol.161, p.110031, Article 110031 |
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| description | •Depression and self-stigma are significant barriers to adherence among adolescents with epilepsy.•Patients with adolescent-onset epilepsy were significantly more adherent to their ASMs compared to those with childhood-onset epilepsy.•The adherent group had significantly lower scores on KSSE and PHQ-9 compared to the non-adherent group.•A positive correlation was found between scores on the KSSE and PHQ-9.
The lifetime prevalence of epilepsy varies between 3.5 and 10.7 per 1000 individuals in developed countries, and from 0.9 to 74.4 per 1000 individuals in Asia, sub-Saharan Africa, and Latin America. In adolescents, the prevalence of epilepsy is estimated to be 1.5 to 2%.
The purpose of this study was to examine the clinical characteristics of adolescents with epilepsy (AWE) and highlight the differences between childhood-onset epilepsy and adolescent-onset epilepsy. Additionally, the study aimed to assess the level of self-stigma and depression, as well as their impact on adherence to antiseizure medication (ASMs).
This cross-sectional study was conducted at the Epilepsy Clinic at Kasr Al-Ainy Hospitals. Patients underwent a thorough evaluation of their seizure history, as well as completed the Adherence to Refills and Medications Scale (ARMS), Kilifi Stigma Scale for Epilepsy (KSSE), and Patient Health Questionnaire-9 (PHQ-9) to assess depression.
A total of 136 AWE were included in the study, consisting of 82 males and 54 females with a median age of 15 and an interquartile range of 13–17. Most patients (54 %) had focal onset seizures, while the remaining 46 % had generalized onset seizures. Of the total sample, 87 (64 %) achieved seizure control for at least one year and are currently taking ASMs. However, only 60 % of the patients were found to be adherent to their ASMs. Fourteen patients (17.2 %) met the criteria for drug-resistant epilepsy. Interestingly, patients with adolescent-onset epilepsy were significantly more adherent to their ASMs compared to those with childhood-onset epilepsy (P=0.01). Additionally, the adherent group had significantly lower scores on KSSE and PHQ-9 compared to the non-adherent group (P= |
| doi_str_mv | 10.1016/j.yebeh.2024.110031 |
| format | Article |
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The lifetime prevalence of epilepsy varies between 3.5 and 10.7 per 1000 individuals in developed countries, and from 0.9 to 74.4 per 1000 individuals in Asia, sub-Saharan Africa, and Latin America. In adolescents, the prevalence of epilepsy is estimated to be 1.5 to 2%.
The purpose of this study was to examine the clinical characteristics of adolescents with epilepsy (AWE) and highlight the differences between childhood-onset epilepsy and adolescent-onset epilepsy. Additionally, the study aimed to assess the level of self-stigma and depression, as well as their impact on adherence to antiseizure medication (ASMs).
This cross-sectional study was conducted at the Epilepsy Clinic at Kasr Al-Ainy Hospitals. Patients underwent a thorough evaluation of their seizure history, as well as completed the Adherence to Refills and Medications Scale (ARMS), Kilifi Stigma Scale for Epilepsy (KSSE), and Patient Health Questionnaire-9 (PHQ-9) to assess depression.
A total of 136 AWE were included in the study, consisting of 82 males and 54 females with a median age of 15 and an interquartile range of 13–17. Most patients (54 %) had focal onset seizures, while the remaining 46 % had generalized onset seizures. Of the total sample, 87 (64 %) achieved seizure control for at least one year and are currently taking ASMs. However, only 60 % of the patients were found to be adherent to their ASMs. Fourteen patients (17.2 %) met the criteria for drug-resistant epilepsy. Interestingly, patients with adolescent-onset epilepsy were significantly more adherent to their ASMs compared to those with childhood-onset epilepsy (P=0.01). Additionally, the adherent group had significantly lower scores on KSSE and PHQ-9 compared to the non-adherent group (P=<0.0001 for each). Furthermore, there was a positive correlation between scores on the KSSE and PHQ-9 (P<0.001).
Depression and self-stigma are significant barriers to adherence among adolescents with epilepsy. These findings highlight the need to involve psychiatrists and epileptologists in epilepsy transition programs.</description><identifier>ISSN: 1525-5050</identifier><identifier>ISSN: 1525-5069</identifier><identifier>EISSN: 1525-5069</identifier><identifier>DOI: 10.1016/j.yebeh.2024.110031</identifier><identifier>PMID: 39306978</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adherence ; Adolescent ; Adolescents with epilepsy ; Anticonvulsants - therapeutic use ; Cross-Sectional Studies ; Depression ; Depression - drug therapy ; Depression - epidemiology ; Depression - psychology ; Egypt - epidemiology ; Epilepsy - drug therapy ; Epilepsy - epidemiology ; Epilepsy - psychology ; Female ; Humans ; Male ; Medication Adherence - psychology ; Medication Adherence - statistics & numerical data ; Psychiatric Status Rating Scales ; Self-stigma ; Social Stigma ; Surveys and Questionnaires</subject><ispartof>Epilepsy & behavior, 2024-12, Vol.161, p.110031, Article 110031</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c239t-252c0c912a199f193e56e7ab8af8656625e4536856cb27b1d54c0d4ec5972b513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.yebeh.2024.110031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39306978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kishk, Nirmeen</creatorcontrib><creatorcontrib>Magdy, Rehab</creatorcontrib><creatorcontrib>El-Sawy, Shereen</creatorcontrib><creatorcontrib>Soliman, Nourhan A.</creatorcontrib><creatorcontrib>Mohamed Fouad, Amr</creatorcontrib><title>Depression and stigma among a sample of Egyptian adolescents with epilepsy and their impact on antiseizure medications adherence</title><title>Epilepsy & behavior</title><addtitle>Epilepsy Behav</addtitle><description>•Depression and self-stigma are significant barriers to adherence among adolescents with epilepsy.•Patients with adolescent-onset epilepsy were significantly more adherent to their ASMs compared to those with childhood-onset epilepsy.•The adherent group had significantly lower scores on KSSE and PHQ-9 compared to the non-adherent group.•A positive correlation was found between scores on the KSSE and PHQ-9.
The lifetime prevalence of epilepsy varies between 3.5 and 10.7 per 1000 individuals in developed countries, and from 0.9 to 74.4 per 1000 individuals in Asia, sub-Saharan Africa, and Latin America. In adolescents, the prevalence of epilepsy is estimated to be 1.5 to 2%.
The purpose of this study was to examine the clinical characteristics of adolescents with epilepsy (AWE) and highlight the differences between childhood-onset epilepsy and adolescent-onset epilepsy. Additionally, the study aimed to assess the level of self-stigma and depression, as well as their impact on adherence to antiseizure medication (ASMs).
This cross-sectional study was conducted at the Epilepsy Clinic at Kasr Al-Ainy Hospitals. Patients underwent a thorough evaluation of their seizure history, as well as completed the Adherence to Refills and Medications Scale (ARMS), Kilifi Stigma Scale for Epilepsy (KSSE), and Patient Health Questionnaire-9 (PHQ-9) to assess depression.
A total of 136 AWE were included in the study, consisting of 82 males and 54 females with a median age of 15 and an interquartile range of 13–17. Most patients (54 %) had focal onset seizures, while the remaining 46 % had generalized onset seizures. Of the total sample, 87 (64 %) achieved seizure control for at least one year and are currently taking ASMs. However, only 60 % of the patients were found to be adherent to their ASMs. Fourteen patients (17.2 %) met the criteria for drug-resistant epilepsy. Interestingly, patients with adolescent-onset epilepsy were significantly more adherent to their ASMs compared to those with childhood-onset epilepsy (P=0.01). Additionally, the adherent group had significantly lower scores on KSSE and PHQ-9 compared to the non-adherent group (P=<0.0001 for each). Furthermore, there was a positive correlation between scores on the KSSE and PHQ-9 (P<0.001).
Depression and self-stigma are significant barriers to adherence among adolescents with epilepsy. These findings highlight the need to involve psychiatrists and epileptologists in epilepsy transition programs.</description><subject>Adherence</subject><subject>Adolescent</subject><subject>Adolescents with epilepsy</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Cross-Sectional Studies</subject><subject>Depression</subject><subject>Depression - drug therapy</subject><subject>Depression - epidemiology</subject><subject>Depression - psychology</subject><subject>Egypt - epidemiology</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - epidemiology</subject><subject>Epilepsy - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medication Adherence - psychology</subject><subject>Medication Adherence - statistics & numerical data</subject><subject>Psychiatric Status Rating Scales</subject><subject>Self-stigma</subject><subject>Social Stigma</subject><subject>Surveys and Questionnaires</subject><issn>1525-5050</issn><issn>1525-5069</issn><issn>1525-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPGzEUha2Kqrz6CypVXrJJ6mvHM-MFCwSUVkJiU9aWx3MncTSv-jqgsOpPx0mAZVf24jvn6H6MfQMxBwHFj_V8izWu5lLIxRxACAWf2AloqWdaFObo46_FMTslWgsBoBV8YcfKqEyU1Qn7d4NTRKIwDtwNDacUlr3jrh-HJXecXD91yMeW3y63UwouU83YIXkcEvHnkFYcp9DhRNt9Pq0wRB76yfnE950pEIaXTUTeYxO8S3mKcssKIw4ez9nn1nWEX9_eM_b48_bP9a_Z_cPd7-ur-5mXyqSZ1NILb0A6MKYFo1AXWLq6cm1V6KKQGhdaFZUufC3LGhq98KJZoNemlLUGdcYuDr1THP9ukJLtQ76i69yA44asAlGpqjRSZlQdUB9HooitnWLoXdxaEHan3q7tXr3dqbcH9Tn1_W1gU-dLPzLvrjNweQAwn_kUMFryYaegCRF9ss0Y_jvwCkqxlz8</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Kishk, Nirmeen</creator><creator>Magdy, Rehab</creator><creator>El-Sawy, Shereen</creator><creator>Soliman, Nourhan A.</creator><creator>Mohamed Fouad, Amr</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202412</creationdate><title>Depression and stigma among a sample of Egyptian adolescents with epilepsy and their impact on antiseizure medications adherence</title><author>Kishk, Nirmeen ; Magdy, Rehab ; El-Sawy, Shereen ; Soliman, Nourhan A. ; Mohamed Fouad, Amr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239t-252c0c912a199f193e56e7ab8af8656625e4536856cb27b1d54c0d4ec5972b513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adherence</topic><topic>Adolescent</topic><topic>Adolescents with epilepsy</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Cross-Sectional Studies</topic><topic>Depression</topic><topic>Depression - drug therapy</topic><topic>Depression - epidemiology</topic><topic>Depression - psychology</topic><topic>Egypt - epidemiology</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - epidemiology</topic><topic>Epilepsy - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medication Adherence - psychology</topic><topic>Medication Adherence - statistics & numerical data</topic><topic>Psychiatric Status Rating Scales</topic><topic>Self-stigma</topic><topic>Social Stigma</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kishk, Nirmeen</creatorcontrib><creatorcontrib>Magdy, Rehab</creatorcontrib><creatorcontrib>El-Sawy, Shereen</creatorcontrib><creatorcontrib>Soliman, Nourhan A.</creatorcontrib><creatorcontrib>Mohamed Fouad, Amr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kishk, Nirmeen</au><au>Magdy, Rehab</au><au>El-Sawy, Shereen</au><au>Soliman, Nourhan A.</au><au>Mohamed Fouad, Amr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression and stigma among a sample of Egyptian adolescents with epilepsy and their impact on antiseizure medications adherence</atitle><jtitle>Epilepsy & behavior</jtitle><addtitle>Epilepsy Behav</addtitle><date>2024-12</date><risdate>2024</risdate><volume>161</volume><spage>110031</spage><pages>110031-</pages><artnum>110031</artnum><issn>1525-5050</issn><issn>1525-5069</issn><eissn>1525-5069</eissn><abstract>•Depression and self-stigma are significant barriers to adherence among adolescents with epilepsy.•Patients with adolescent-onset epilepsy were significantly more adherent to their ASMs compared to those with childhood-onset epilepsy.•The adherent group had significantly lower scores on KSSE and PHQ-9 compared to the non-adherent group.•A positive correlation was found between scores on the KSSE and PHQ-9.
The lifetime prevalence of epilepsy varies between 3.5 and 10.7 per 1000 individuals in developed countries, and from 0.9 to 74.4 per 1000 individuals in Asia, sub-Saharan Africa, and Latin America. In adolescents, the prevalence of epilepsy is estimated to be 1.5 to 2%.
The purpose of this study was to examine the clinical characteristics of adolescents with epilepsy (AWE) and highlight the differences between childhood-onset epilepsy and adolescent-onset epilepsy. Additionally, the study aimed to assess the level of self-stigma and depression, as well as their impact on adherence to antiseizure medication (ASMs).
This cross-sectional study was conducted at the Epilepsy Clinic at Kasr Al-Ainy Hospitals. Patients underwent a thorough evaluation of their seizure history, as well as completed the Adherence to Refills and Medications Scale (ARMS), Kilifi Stigma Scale for Epilepsy (KSSE), and Patient Health Questionnaire-9 (PHQ-9) to assess depression.
A total of 136 AWE were included in the study, consisting of 82 males and 54 females with a median age of 15 and an interquartile range of 13–17. Most patients (54 %) had focal onset seizures, while the remaining 46 % had generalized onset seizures. Of the total sample, 87 (64 %) achieved seizure control for at least one year and are currently taking ASMs. However, only 60 % of the patients were found to be adherent to their ASMs. Fourteen patients (17.2 %) met the criteria for drug-resistant epilepsy. Interestingly, patients with adolescent-onset epilepsy were significantly more adherent to their ASMs compared to those with childhood-onset epilepsy (P=0.01). Additionally, the adherent group had significantly lower scores on KSSE and PHQ-9 compared to the non-adherent group (P=<0.0001 for each). Furthermore, there was a positive correlation between scores on the KSSE and PHQ-9 (P<0.001).
Depression and self-stigma are significant barriers to adherence among adolescents with epilepsy. These findings highlight the need to involve psychiatrists and epileptologists in epilepsy transition programs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39306978</pmid><doi>10.1016/j.yebeh.2024.110031</doi></addata></record> |
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| subjects | Adherence Adolescent Adolescents with epilepsy Anticonvulsants - therapeutic use Cross-Sectional Studies Depression Depression - drug therapy Depression - epidemiology Depression - psychology Egypt - epidemiology Epilepsy - drug therapy Epilepsy - epidemiology Epilepsy - psychology Female Humans Male Medication Adherence - psychology Medication Adherence - statistics & numerical data Psychiatric Status Rating Scales Self-stigma Social Stigma Surveys and Questionnaires |
| title | Depression and stigma among a sample of Egyptian adolescents with epilepsy and their impact on antiseizure medications adherence |
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