Tetrabenazine, a vesicular monoamine transporter 2 inhibitor, inhibits vesicular storage capacity and release of monoamine transmitters in mouse brain tissue

Background and Purpose Tetrabenazine (TBZ), used for treating hyperkinetic disorders, inhibits vesicular monoamine transporter‐2 (VMAT‐2), which sequesters monoamines into vesicles for exocytosis. However, our knowledge of the effect of TBZ on monoaminergic transmission is limited. Herein, we provid...

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Veröffentlicht in:	British journal of pharmacology 2024-12, Vol.181 (24), p.5094-5109
Hauptverfasser:	Tod, Pál, Varga, Anita, Román, Viktor, Lendvai, Balázs, Pálkovács, Roland, Sperlágh, Beáta, Vizi, E. Sylvester
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - metabolism Adrenergic Uptake Inhibitors - pharmacology Animals Biogenic Monoamines - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - metabolism Dopamine receptors Exocytosis hyperkinesis Locomotor activity Male MDMA Mice Motor Activity - drug effects mouse model Movement disorders N-Methyl-3,4-methylenedioxyamphetamine - pharmacology Neostriatum Neurotransmitter release Norepinephrine Norepinephrine - metabolism Prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Serotonin - metabolism Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism Tetrabenazine Tetrabenazine - analogs & derivatives Tetrabenazine - pharmacology Vesamicol vesicular monoamine transport proteins Vesicular Monoamine Transport Proteins - antagonists & inhibitors Vesicular Monoamine Transport Proteins - metabolism Vesicular monoamine transporter Vesicular monoamine transporter 2
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