Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data

Background The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry. Methods Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were c...

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Veröffentlicht in:Journal of neurology 2024-12, Vol.271 (12), p.7525-7536
Hauptverfasser: Pekmezovic, Tatjana, Jovicevic, Vanja, Andabaka, Marko, Momcilovic, Nikola, Veselinovic, Nikola, Tamas, Olivera, Budmkic, Maja, Todorovic, Stefan, Jeremic, Marta, Dincic, Evica, Vojinovic, Slobodan, Andrejevic, Sladjana, Mesaros, Sarlota, Drulovic, Jelena
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container_end_page 7536
container_issue 12
container_start_page 7525
container_title Journal of neurology
container_volume 271
creator Pekmezovic, Tatjana
Jovicevic, Vanja
Andabaka, Marko
Momcilovic, Nikola
Veselinovic, Nikola
Tamas, Olivera
Budmkic, Maja
Todorovic, Stefan
Jeremic, Marta
Dincic, Evica
Vojinovic, Slobodan
Andrejevic, Sladjana
Mesaros, Sarlota
Drulovic, Jelena
description Background The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry. Methods Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG. Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative ( p  = 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4–18.5, p  = 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren’s syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant ( p  = 0.009, and p  = 0.015, respectively). Conclusion In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients.
doi_str_mv 10.1007/s00415-024-12698-2
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Methods Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG. Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative ( p  = 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4–18.5, p  = 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren’s syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant ( p  = 0.009, and p  = 0.015, respectively). Conclusion In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients.</description><identifier>ISSN: 0340-5354</identifier><identifier>ISSN: 1432-1459</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-024-12698-2</identifier><identifier>PMID: 39306828</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Antibodies ; Antinuclear antibodies ; Antiphospholipid antibodies ; Aquaporin 4 ; Aquaporin 4 - immunology ; Autoantibodies ; Autoantibodies - blood ; Autoimmune diseases ; Autoimmune Diseases - blood ; Autoimmune Diseases - epidemiology ; Autoimmune Diseases - immunology ; Comorbidity ; Female ; Humans ; Immunoglobulin G ; Immunoglobulin G - blood ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Myasthenia gravis ; Myelin ; Neurology ; Neuromuscular junctions ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - epidemiology ; Neuromyelitis Optica - immunology ; Neuroradiology ; Neurosciences ; Oligodendrocyte-myelin glycoprotein ; Original Communication ; Population studies ; Registries ; Serbia - epidemiology ; Sjogren's syndrome ; Statistical analysis ; Systemic lupus erythematosus ; Thyroid diseases ; Young Adult</subject><ispartof>Journal of neurology, 2024-12, Vol.271 (12), p.7525-7536</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-fb8f9d5539b7fd61383aad351ae7a524da9a21666b6e038d9f1fd3fdaf13c1e13</cites><orcidid>0000-0001-7978-1409</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-024-12698-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-024-12698-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39306828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pekmezovic, Tatjana</creatorcontrib><creatorcontrib>Jovicevic, Vanja</creatorcontrib><creatorcontrib>Andabaka, Marko</creatorcontrib><creatorcontrib>Momcilovic, Nikola</creatorcontrib><creatorcontrib>Veselinovic, Nikola</creatorcontrib><creatorcontrib>Tamas, Olivera</creatorcontrib><creatorcontrib>Budmkic, Maja</creatorcontrib><creatorcontrib>Todorovic, Stefan</creatorcontrib><creatorcontrib>Jeremic, Marta</creatorcontrib><creatorcontrib>Dincic, Evica</creatorcontrib><creatorcontrib>Vojinovic, Slobodan</creatorcontrib><creatorcontrib>Andrejevic, Sladjana</creatorcontrib><creatorcontrib>Mesaros, Sarlota</creatorcontrib><creatorcontrib>Drulovic, Jelena</creatorcontrib><title>Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry. Methods Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG. Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative ( p  = 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4–18.5, p  = 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren’s syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant ( p  = 0.009, and p  = 0.015, respectively). Conclusion In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Antinuclear antibodies</subject><subject>Antiphospholipid antibodies</subject><subject>Aquaporin 4</subject><subject>Aquaporin 4 - immunology</subject><subject>Autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - blood</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>Autoimmune Diseases - immunology</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Myasthenia gravis</subject><subject>Myelin</subject><subject>Neurology</subject><subject>Neuromuscular junctions</subject><subject>Neuromyelitis Optica - blood</subject><subject>Neuromyelitis Optica - epidemiology</subject><subject>Neuromyelitis Optica - immunology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Oligodendrocyte-myelin glycoprotein</subject><subject>Original Communication</subject><subject>Population studies</subject><subject>Registries</subject><subject>Serbia - epidemiology</subject><subject>Sjogren's syndrome</subject><subject>Statistical analysis</subject><subject>Systemic lupus erythematosus</subject><subject>Thyroid diseases</subject><subject>Young Adult</subject><issn>0340-5354</issn><issn>1432-1459</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uFiEUhonR2M_qDbgwJG7coPwMM4y7ptrapNqFuibMAJ_UGZhyGJPvLrzkUqdq4sIVIe_Dy8l5EHrO6GtGafcGKG2YJJQ3hPG2V4Q_QDvWCE5YI_uHaEdFQ4kUsjlCTwCuKaWqBo_RkegFbRVXO_Tz5GY1S8ohNuRif47B5bQkCCX8COWAIexj8GE0sUwHHOKYnQEHuHxzOAf4jpPHY5pTHoLFZi0pzPMaHbYBNjBE_Onj1ed3eDEluFjgLV7Ssk71liIZKmNxdvsAJR-wNcU8RY-8mcA9uz-P0dez919OP5DLq_OL05NLMnLZFuIH5XsrpeiHztuWCSWMsUIy4zojeWNNbzhr23ZoHRXK9p55K7w1nomROSaO0autd8npZnVQ9BxgdNNkoksraMFo16lGCF7Rl_-g12nNsU5XKVE33ypFK8U3aswJIDuvlxxmkw-aUX3nS2--dPWlf_nSd9Uv7qvXYXb2z5PfgiogNgBqFPcu__37P7W3d8qjoQ</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Pekmezovic, Tatjana</creator><creator>Jovicevic, Vanja</creator><creator>Andabaka, Marko</creator><creator>Momcilovic, Nikola</creator><creator>Veselinovic, Nikola</creator><creator>Tamas, Olivera</creator><creator>Budmkic, Maja</creator><creator>Todorovic, Stefan</creator><creator>Jeremic, Marta</creator><creator>Dincic, Evica</creator><creator>Vojinovic, Slobodan</creator><creator>Andrejevic, Sladjana</creator><creator>Mesaros, Sarlota</creator><creator>Drulovic, Jelena</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7978-1409</orcidid></search><sort><creationdate>20241201</creationdate><title>Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data</title><author>Pekmezovic, Tatjana ; Jovicevic, Vanja ; Andabaka, Marko ; Momcilovic, Nikola ; Veselinovic, Nikola ; Tamas, Olivera ; Budmkic, Maja ; Todorovic, Stefan ; Jeremic, Marta ; Dincic, Evica ; Vojinovic, Slobodan ; Andrejevic, Sladjana ; Mesaros, Sarlota ; Drulovic, Jelena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-fb8f9d5539b7fd61383aad351ae7a524da9a21666b6e038d9f1fd3fdaf13c1e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Antinuclear antibodies</topic><topic>Antiphospholipid antibodies</topic><topic>Aquaporin 4</topic><topic>Aquaporin 4 - immunology</topic><topic>Autoantibodies</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - blood</topic><topic>Autoimmune Diseases - epidemiology</topic><topic>Autoimmune Diseases - immunology</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Myasthenia gravis</topic><topic>Myelin</topic><topic>Neurology</topic><topic>Neuromuscular junctions</topic><topic>Neuromyelitis Optica - blood</topic><topic>Neuromyelitis Optica - epidemiology</topic><topic>Neuromyelitis Optica - immunology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Oligodendrocyte-myelin glycoprotein</topic><topic>Original Communication</topic><topic>Population studies</topic><topic>Registries</topic><topic>Serbia - epidemiology</topic><topic>Sjogren's syndrome</topic><topic>Statistical analysis</topic><topic>Systemic lupus erythematosus</topic><topic>Thyroid diseases</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pekmezovic, Tatjana</creatorcontrib><creatorcontrib>Jovicevic, Vanja</creatorcontrib><creatorcontrib>Andabaka, Marko</creatorcontrib><creatorcontrib>Momcilovic, Nikola</creatorcontrib><creatorcontrib>Veselinovic, Nikola</creatorcontrib><creatorcontrib>Tamas, Olivera</creatorcontrib><creatorcontrib>Budmkic, Maja</creatorcontrib><creatorcontrib>Todorovic, Stefan</creatorcontrib><creatorcontrib>Jeremic, Marta</creatorcontrib><creatorcontrib>Dincic, Evica</creatorcontrib><creatorcontrib>Vojinovic, Slobodan</creatorcontrib><creatorcontrib>Andrejevic, Sladjana</creatorcontrib><creatorcontrib>Mesaros, Sarlota</creatorcontrib><creatorcontrib>Drulovic, Jelena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pekmezovic, Tatjana</au><au>Jovicevic, Vanja</au><au>Andabaka, Marko</au><au>Momcilovic, Nikola</au><au>Veselinovic, Nikola</au><au>Tamas, Olivera</au><au>Budmkic, Maja</au><au>Todorovic, Stefan</au><au>Jeremic, Marta</au><au>Dincic, Evica</au><au>Vojinovic, Slobodan</au><au>Andrejevic, Sladjana</au><au>Mesaros, Sarlota</au><au>Drulovic, Jelena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>271</volume><issue>12</issue><spage>7525</spage><epage>7536</epage><pages>7525-7536</pages><issn>0340-5354</issn><issn>1432-1459</issn><eissn>1432-1459</eissn><abstract>Background The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry. Methods Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG. Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative ( p  = 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4–18.5, p  = 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren’s syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant ( p  = 0.009, and p  = 0.015, respectively). Conclusion In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39306828</pmid><doi>10.1007/s00415-024-12698-2</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7978-1409</orcidid></addata></record>
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source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Adult
Aged
Antibodies
Antinuclear antibodies
Antiphospholipid antibodies
Aquaporin 4
Aquaporin 4 - immunology
Autoantibodies
Autoantibodies - blood
Autoimmune diseases
Autoimmune Diseases - blood
Autoimmune Diseases - epidemiology
Autoimmune Diseases - immunology
Comorbidity
Female
Humans
Immunoglobulin G
Immunoglobulin G - blood
Male
Medicine
Medicine & Public Health
Middle Aged
Myasthenia gravis
Myelin
Neurology
Neuromuscular junctions
Neuromyelitis Optica - blood
Neuromyelitis Optica - epidemiology
Neuromyelitis Optica - immunology
Neuroradiology
Neurosciences
Oligodendrocyte-myelin glycoprotein
Original Communication
Population studies
Registries
Serbia - epidemiology
Sjogren's syndrome
Statistical analysis
Systemic lupus erythematosus
Thyroid diseases
Young Adult
title Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data
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