Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data
Background The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry. Methods Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were c...
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creator | Pekmezovic, Tatjana Jovicevic, Vanja Andabaka, Marko Momcilovic, Nikola Veselinovic, Nikola Tamas, Olivera Budmkic, Maja Todorovic, Stefan Jeremic, Marta Dincic, Evica Vojinovic, Slobodan Andrejevic, Sladjana Mesaros, Sarlota Drulovic, Jelena |
description | Background
The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry.
Methods
Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG. Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative (
p
= 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4–18.5,
p
= 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren’s syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant (
p
= 0.009, and
p
= 0.015, respectively).
Conclusion
In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients. |
doi_str_mv | 10.1007/s00415-024-12698-2 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3107784332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3107784332</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-fb8f9d5539b7fd61383aad351ae7a524da9a21666b6e038d9f1fd3fdaf13c1e13</originalsourceid><addsrcrecordid>eNp9kc1uFiEUhonR2M_qDbgwJG7coPwMM4y7ptrapNqFuibMAJ_UGZhyGJPvLrzkUqdq4sIVIe_Dy8l5EHrO6GtGafcGKG2YJJQ3hPG2V4Q_QDvWCE5YI_uHaEdFQ4kUsjlCTwCuKaWqBo_RkegFbRVXO_Tz5GY1S8ohNuRif47B5bQkCCX8COWAIexj8GE0sUwHHOKYnQEHuHxzOAf4jpPHY5pTHoLFZi0pzPMaHbYBNjBE_Onj1ed3eDEluFjgLV7Ssk71liIZKmNxdvsAJR-wNcU8RY-8mcA9uz-P0dez919OP5DLq_OL05NLMnLZFuIH5XsrpeiHztuWCSWMsUIy4zojeWNNbzhr23ZoHRXK9p55K7w1nomROSaO0autd8npZnVQ9BxgdNNkoksraMFo16lGCF7Rl_-g12nNsU5XKVE33ypFK8U3aswJIDuvlxxmkw-aUX3nS2--dPWlf_nSd9Uv7qvXYXb2z5PfgiogNgBqFPcu__37P7W3d8qjoQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3132696880</pqid></control><display><type>article</type><title>Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Pekmezovic, Tatjana ; Jovicevic, Vanja ; Andabaka, Marko ; Momcilovic, Nikola ; Veselinovic, Nikola ; Tamas, Olivera ; Budmkic, Maja ; Todorovic, Stefan ; Jeremic, Marta ; Dincic, Evica ; Vojinovic, Slobodan ; Andrejevic, Sladjana ; Mesaros, Sarlota ; Drulovic, Jelena</creator><creatorcontrib>Pekmezovic, Tatjana ; Jovicevic, Vanja ; Andabaka, Marko ; Momcilovic, Nikola ; Veselinovic, Nikola ; Tamas, Olivera ; Budmkic, Maja ; Todorovic, Stefan ; Jeremic, Marta ; Dincic, Evica ; Vojinovic, Slobodan ; Andrejevic, Sladjana ; Mesaros, Sarlota ; Drulovic, Jelena</creatorcontrib><description>Background
The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry.
Methods
Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG. Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative (
p
= 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4–18.5,
p
= 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren’s syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant (
p
= 0.009, and
p
= 0.015, respectively).
Conclusion
In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients.</description><identifier>ISSN: 0340-5354</identifier><identifier>ISSN: 1432-1459</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-024-12698-2</identifier><identifier>PMID: 39306828</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Antibodies ; Antinuclear antibodies ; Antiphospholipid antibodies ; Aquaporin 4 ; Aquaporin 4 - immunology ; Autoantibodies ; Autoantibodies - blood ; Autoimmune diseases ; Autoimmune Diseases - blood ; Autoimmune Diseases - epidemiology ; Autoimmune Diseases - immunology ; Comorbidity ; Female ; Humans ; Immunoglobulin G ; Immunoglobulin G - blood ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myasthenia gravis ; Myelin ; Neurology ; Neuromuscular junctions ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - epidemiology ; Neuromyelitis Optica - immunology ; Neuroradiology ; Neurosciences ; Oligodendrocyte-myelin glycoprotein ; Original Communication ; Population studies ; Registries ; Serbia - epidemiology ; Sjogren's syndrome ; Statistical analysis ; Systemic lupus erythematosus ; Thyroid diseases ; Young Adult</subject><ispartof>Journal of neurology, 2024-12, Vol.271 (12), p.7525-7536</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-fb8f9d5539b7fd61383aad351ae7a524da9a21666b6e038d9f1fd3fdaf13c1e13</cites><orcidid>0000-0001-7978-1409</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-024-12698-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-024-12698-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39306828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pekmezovic, Tatjana</creatorcontrib><creatorcontrib>Jovicevic, Vanja</creatorcontrib><creatorcontrib>Andabaka, Marko</creatorcontrib><creatorcontrib>Momcilovic, Nikola</creatorcontrib><creatorcontrib>Veselinovic, Nikola</creatorcontrib><creatorcontrib>Tamas, Olivera</creatorcontrib><creatorcontrib>Budmkic, Maja</creatorcontrib><creatorcontrib>Todorovic, Stefan</creatorcontrib><creatorcontrib>Jeremic, Marta</creatorcontrib><creatorcontrib>Dincic, Evica</creatorcontrib><creatorcontrib>Vojinovic, Slobodan</creatorcontrib><creatorcontrib>Andrejevic, Sladjana</creatorcontrib><creatorcontrib>Mesaros, Sarlota</creatorcontrib><creatorcontrib>Drulovic, Jelena</creatorcontrib><title>Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background
The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry.
Methods
Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG. Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative (
p
= 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4–18.5,
p
= 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren’s syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant (
p
= 0.009, and
p
= 0.015, respectively).
Conclusion
In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>Antinuclear antibodies</subject><subject>Antiphospholipid antibodies</subject><subject>Aquaporin 4</subject><subject>Aquaporin 4 - immunology</subject><subject>Autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - blood</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>Autoimmune Diseases - immunology</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myasthenia gravis</subject><subject>Myelin</subject><subject>Neurology</subject><subject>Neuromuscular junctions</subject><subject>Neuromyelitis Optica - blood</subject><subject>Neuromyelitis Optica - epidemiology</subject><subject>Neuromyelitis Optica - immunology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Oligodendrocyte-myelin glycoprotein</subject><subject>Original Communication</subject><subject>Population studies</subject><subject>Registries</subject><subject>Serbia - epidemiology</subject><subject>Sjogren's syndrome</subject><subject>Statistical analysis</subject><subject>Systemic lupus erythematosus</subject><subject>Thyroid diseases</subject><subject>Young Adult</subject><issn>0340-5354</issn><issn>1432-1459</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uFiEUhonR2M_qDbgwJG7coPwMM4y7ptrapNqFuibMAJ_UGZhyGJPvLrzkUqdq4sIVIe_Dy8l5EHrO6GtGafcGKG2YJJQ3hPG2V4Q_QDvWCE5YI_uHaEdFQ4kUsjlCTwCuKaWqBo_RkegFbRVXO_Tz5GY1S8ohNuRif47B5bQkCCX8COWAIexj8GE0sUwHHOKYnQEHuHxzOAf4jpPHY5pTHoLFZi0pzPMaHbYBNjBE_Onj1ed3eDEluFjgLV7Ssk71liIZKmNxdvsAJR-wNcU8RY-8mcA9uz-P0dez919OP5DLq_OL05NLMnLZFuIH5XsrpeiHztuWCSWMsUIy4zojeWNNbzhr23ZoHRXK9p55K7w1nomROSaO0autd8npZnVQ9BxgdNNkoksraMFo16lGCF7Rl_-g12nNsU5XKVE33ypFK8U3aswJIDuvlxxmkw-aUX3nS2--dPWlf_nSd9Uv7qvXYXb2z5PfgiogNgBqFPcu__37P7W3d8qjoQ</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Pekmezovic, Tatjana</creator><creator>Jovicevic, Vanja</creator><creator>Andabaka, Marko</creator><creator>Momcilovic, Nikola</creator><creator>Veselinovic, Nikola</creator><creator>Tamas, Olivera</creator><creator>Budmkic, Maja</creator><creator>Todorovic, Stefan</creator><creator>Jeremic, Marta</creator><creator>Dincic, Evica</creator><creator>Vojinovic, Slobodan</creator><creator>Andrejevic, Sladjana</creator><creator>Mesaros, Sarlota</creator><creator>Drulovic, Jelena</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7978-1409</orcidid></search><sort><creationdate>20241201</creationdate><title>Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data</title><author>Pekmezovic, Tatjana ; Jovicevic, Vanja ; Andabaka, Marko ; Momcilovic, Nikola ; Veselinovic, Nikola ; Tamas, Olivera ; Budmkic, Maja ; Todorovic, Stefan ; Jeremic, Marta ; Dincic, Evica ; Vojinovic, Slobodan ; Andrejevic, Sladjana ; Mesaros, Sarlota ; Drulovic, Jelena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-fb8f9d5539b7fd61383aad351ae7a524da9a21666b6e038d9f1fd3fdaf13c1e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>Antinuclear antibodies</topic><topic>Antiphospholipid antibodies</topic><topic>Aquaporin 4</topic><topic>Aquaporin 4 - immunology</topic><topic>Autoantibodies</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - blood</topic><topic>Autoimmune Diseases - epidemiology</topic><topic>Autoimmune Diseases - immunology</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myasthenia gravis</topic><topic>Myelin</topic><topic>Neurology</topic><topic>Neuromuscular junctions</topic><topic>Neuromyelitis Optica - blood</topic><topic>Neuromyelitis Optica - epidemiology</topic><topic>Neuromyelitis Optica - immunology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Oligodendrocyte-myelin glycoprotein</topic><topic>Original Communication</topic><topic>Population studies</topic><topic>Registries</topic><topic>Serbia - epidemiology</topic><topic>Sjogren's syndrome</topic><topic>Statistical analysis</topic><topic>Systemic lupus erythematosus</topic><topic>Thyroid diseases</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pekmezovic, Tatjana</creatorcontrib><creatorcontrib>Jovicevic, Vanja</creatorcontrib><creatorcontrib>Andabaka, Marko</creatorcontrib><creatorcontrib>Momcilovic, Nikola</creatorcontrib><creatorcontrib>Veselinovic, Nikola</creatorcontrib><creatorcontrib>Tamas, Olivera</creatorcontrib><creatorcontrib>Budmkic, Maja</creatorcontrib><creatorcontrib>Todorovic, Stefan</creatorcontrib><creatorcontrib>Jeremic, Marta</creatorcontrib><creatorcontrib>Dincic, Evica</creatorcontrib><creatorcontrib>Vojinovic, Slobodan</creatorcontrib><creatorcontrib>Andrejevic, Sladjana</creatorcontrib><creatorcontrib>Mesaros, Sarlota</creatorcontrib><creatorcontrib>Drulovic, Jelena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pekmezovic, Tatjana</au><au>Jovicevic, Vanja</au><au>Andabaka, Marko</au><au>Momcilovic, Nikola</au><au>Veselinovic, Nikola</au><au>Tamas, Olivera</au><au>Budmkic, Maja</au><au>Todorovic, Stefan</au><au>Jeremic, Marta</au><au>Dincic, Evica</au><au>Vojinovic, Slobodan</au><au>Andrejevic, Sladjana</au><au>Mesaros, Sarlota</au><au>Drulovic, Jelena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>271</volume><issue>12</issue><spage>7525</spage><epage>7536</epage><pages>7525-7536</pages><issn>0340-5354</issn><issn>1432-1459</issn><eissn>1432-1459</eissn><abstract>Background
The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry.
Methods
Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG. Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative (
p
= 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4–18.5,
p
= 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren’s syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant (
p
= 0.009, and
p
= 0.015, respectively).
Conclusion
In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39306828</pmid><doi>10.1007/s00415-024-12698-2</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7978-1409</orcidid></addata></record> |
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subjects | Adult Aged Antibodies Antinuclear antibodies Antiphospholipid antibodies Aquaporin 4 Aquaporin 4 - immunology Autoantibodies Autoantibodies - blood Autoimmune diseases Autoimmune Diseases - blood Autoimmune Diseases - epidemiology Autoimmune Diseases - immunology Comorbidity Female Humans Immunoglobulin G Immunoglobulin G - blood Male Medicine Medicine & Public Health Middle Aged Myasthenia gravis Myelin Neurology Neuromuscular junctions Neuromyelitis Optica - blood Neuromyelitis Optica - epidemiology Neuromyelitis Optica - immunology Neuroradiology Neurosciences Oligodendrocyte-myelin glycoprotein Original Communication Population studies Registries Serbia - epidemiology Sjogren's syndrome Statistical analysis Systemic lupus erythematosus Thyroid diseases Young Adult |
title | Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data |
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