Safe concentration, unsafe effects: Impact of BPA on antioxidant function in the hepatopancreas and ovarian gene expression in oriental river prawns (Macrobrachium nipponense)
•The 24hLC50 and 48hLC50 of BPA for M. nipponense are 80.59 and 63.90 mg/L.•BPA enhances ovarian gene expression, causing precocious puberty and miniaturization.•Even safe-level BPA causes oxidative stress, affecting ovarian development.•The biological damage caused by BPA is reversible. This study...
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| Veröffentlicht in: | Aquatic toxicology 2024-11, Vol.276, p.107103, Article 107103 |
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| creator | Zhao, Weihong Zheng, Xirui Jiang, Fengjuan Liu, Jintao Wang, Shuhao Ou, Jiangtao |
| description | •The 24hLC50 and 48hLC50 of BPA for M. nipponense are 80.59 and 63.90 mg/L.•BPA enhances ovarian gene expression, causing precocious puberty and miniaturization.•Even safe-level BPA causes oxidative stress, affecting ovarian development.•The biological damage caused by BPA is reversible.
This study investigated the effects of Bisphenol A (BPA), a common endocrine-disrupting chemical, on the antioxidant enzyme activities in the hepatopancreas and the expression of genes related to ovarian development in oriental river prawns (Macrobrachium nipponense). The 24hLC50 and 48hLC50 values for BPA were 80.59 mg/L and 63.90 mg/L, respectively, with a safe concentration of 12.06 mg/L. Prawns were exposed to low (4.85 mg/L), safe (12.06 mg/L), and high (30.00 mg/L) concentrations of BPA for 10 days to measure enzyme activities, and for 20 days followed by 7 days in BPA-free water to measure gene expression.
Short-term exposure (12 h, 1d, 3d) to low concentration BPA did not significantly affect superoxide dismutase (SOD) activity in the hepatopancreas (P > 0.05), but long-term exposure (6d, 10d) significantly reduced SOD activity (P < 0.05). Catalase (CAT) activity showed no significant changes throughout the low concentration exposure period (P > 0.05). At safe and high concentrations, SOD and CAT activities significantly decreased after 12 h of exposure (P < 0.05).
BPA affected heat shock protein 90 (HSP90) expression in the ovary, with low concentration BPA significantly upregulating HSP90 after 1 day (P < 0.05), but returning to normal levels after 10 and 20 days. At the safe concentration, HSP90 was significantly upregulated at all three sampling points (1d, 10d, 20d) (P < 0.05), while high concentration exposure led to significant upregulation only on day 10 (P < 0.05).
Low concentration BPA had no significant effect on Cathepsin B (CB) and Cathepsin L (CL) gene expression in the ovaries (P > 0.05). However, safe concentration exposure promoted CB expression on days 1, 10, and 20 (P < 0.05), while high concentration exposure significantly increased CB expression on day 1 (P < 0.05), with levels returning to normal on days 10 and 20. CL expression significantly increased after 20 days of exposure to both safe and high concentrations (P < 0.05). Gene expression levels in the ovaries returned to normal after transfer to BPA-free water, with HSP90 and CB normalizing by day 1, and CL by day 7.
These results indicate that even safe concentrations of BPA impose stress |
| doi_str_mv | 10.1016/j.aquatox.2024.107103 |
| format | Article |
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This study investigated the effects of Bisphenol A (BPA), a common endocrine-disrupting chemical, on the antioxidant enzyme activities in the hepatopancreas and the expression of genes related to ovarian development in oriental river prawns (Macrobrachium nipponense). The 24hLC50 and 48hLC50 values for BPA were 80.59 mg/L and 63.90 mg/L, respectively, with a safe concentration of 12.06 mg/L. Prawns were exposed to low (4.85 mg/L), safe (12.06 mg/L), and high (30.00 mg/L) concentrations of BPA for 10 days to measure enzyme activities, and for 20 days followed by 7 days in BPA-free water to measure gene expression.
Short-term exposure (12 h, 1d, 3d) to low concentration BPA did not significantly affect superoxide dismutase (SOD) activity in the hepatopancreas (P > 0.05), but long-term exposure (6d, 10d) significantly reduced SOD activity (P < 0.05). Catalase (CAT) activity showed no significant changes throughout the low concentration exposure period (P > 0.05). At safe and high concentrations, SOD and CAT activities significantly decreased after 12 h of exposure (P < 0.05).
BPA affected heat shock protein 90 (HSP90) expression in the ovary, with low concentration BPA significantly upregulating HSP90 after 1 day (P < 0.05), but returning to normal levels after 10 and 20 days. At the safe concentration, HSP90 was significantly upregulated at all three sampling points (1d, 10d, 20d) (P < 0.05), while high concentration exposure led to significant upregulation only on day 10 (P < 0.05).
Low concentration BPA had no significant effect on Cathepsin B (CB) and Cathepsin L (CL) gene expression in the ovaries (P > 0.05). However, safe concentration exposure promoted CB expression on days 1, 10, and 20 (P < 0.05), while high concentration exposure significantly increased CB expression on day 1 (P < 0.05), with levels returning to normal on days 10 and 20. CL expression significantly increased after 20 days of exposure to both safe and high concentrations (P < 0.05). Gene expression levels in the ovaries returned to normal after transfer to BPA-free water, with HSP90 and CB normalizing by day 1, and CL by day 7.
These results indicate that even safe concentrations of BPA impose stress on the hepatopancreas and increase the expression of HSP90, CB, and CL genes in the ovaries, affecting ovarian development. And, these effects are reversible within a certain period after the removal of BPA.]]></description><identifier>ISSN: 0166-445X</identifier><identifier>ISSN: 1879-1514</identifier><identifier>EISSN: 1879-1514</identifier><identifier>DOI: 10.1016/j.aquatox.2024.107103</identifier><identifier>PMID: 39305710</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>acute exposure ; Acute lethal effect ; Animals ; antioxidant activity ; antioxidant enzymes ; Antioxidant reductase ; Antioxidants - metabolism ; Benzhydryl Compounds - toxicity ; Bisphenol A ; catalase ; Catalase - genetics ; Catalase - metabolism ; Cathepsin B ; Cathepsin L ; chronic exposure ; Endocrine Disruptors - toxicity ; endocrine-disrupting chemicals ; Female ; gene expression ; Gene Expression Regulation - drug effects ; Heat shock protein 90 ; hepatopancreas ; Hepatopancreas - drug effects ; Hepatopancreas - metabolism ; HSP90 Heat-Shock Proteins - genetics ; HSP90 Heat-Shock Proteins - metabolism ; Macrobrachium nipponense ; ovarian development ; Ovary - drug effects ; Ovary - metabolism ; Palaemonidae - drug effects ; Palaemonidae - genetics ; Phenols - toxicity ; rivers ; superoxide dismutase ; Superoxide Dismutase - genetics ; Superoxide Dismutase - metabolism ; toxicology ; Water Pollutants, Chemical - toxicity</subject><ispartof>Aquatic toxicology, 2024-11, Vol.276, p.107103, Article 107103</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c276t-1a01c4838cca5f8c1203fe5c857725a6485206115bd0af46e1582d8c118161243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166445X2400273X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39305710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Weihong</creatorcontrib><creatorcontrib>Zheng, Xirui</creatorcontrib><creatorcontrib>Jiang, Fengjuan</creatorcontrib><creatorcontrib>Liu, Jintao</creatorcontrib><creatorcontrib>Wang, Shuhao</creatorcontrib><creatorcontrib>Ou, Jiangtao</creatorcontrib><title>Safe concentration, unsafe effects: Impact of BPA on antioxidant function in the hepatopancreas and ovarian gene expression in oriental river prawns (Macrobrachium nipponense)</title><title>Aquatic toxicology</title><addtitle>Aquat Toxicol</addtitle><description><![CDATA[•The 24hLC50 and 48hLC50 of BPA for M. nipponense are 80.59 and 63.90 mg/L.•BPA enhances ovarian gene expression, causing precocious puberty and miniaturization.•Even safe-level BPA causes oxidative stress, affecting ovarian development.•The biological damage caused by BPA is reversible.
This study investigated the effects of Bisphenol A (BPA), a common endocrine-disrupting chemical, on the antioxidant enzyme activities in the hepatopancreas and the expression of genes related to ovarian development in oriental river prawns (Macrobrachium nipponense). The 24hLC50 and 48hLC50 values for BPA were 80.59 mg/L and 63.90 mg/L, respectively, with a safe concentration of 12.06 mg/L. Prawns were exposed to low (4.85 mg/L), safe (12.06 mg/L), and high (30.00 mg/L) concentrations of BPA for 10 days to measure enzyme activities, and for 20 days followed by 7 days in BPA-free water to measure gene expression.
Short-term exposure (12 h, 1d, 3d) to low concentration BPA did not significantly affect superoxide dismutase (SOD) activity in the hepatopancreas (P > 0.05), but long-term exposure (6d, 10d) significantly reduced SOD activity (P < 0.05). Catalase (CAT) activity showed no significant changes throughout the low concentration exposure period (P > 0.05). At safe and high concentrations, SOD and CAT activities significantly decreased after 12 h of exposure (P < 0.05).
BPA affected heat shock protein 90 (HSP90) expression in the ovary, with low concentration BPA significantly upregulating HSP90 after 1 day (P < 0.05), but returning to normal levels after 10 and 20 days. At the safe concentration, HSP90 was significantly upregulated at all three sampling points (1d, 10d, 20d) (P < 0.05), while high concentration exposure led to significant upregulation only on day 10 (P < 0.05).
Low concentration BPA had no significant effect on Cathepsin B (CB) and Cathepsin L (CL) gene expression in the ovaries (P > 0.05). However, safe concentration exposure promoted CB expression on days 1, 10, and 20 (P < 0.05), while high concentration exposure significantly increased CB expression on day 1 (P < 0.05), with levels returning to normal on days 10 and 20. CL expression significantly increased after 20 days of exposure to both safe and high concentrations (P < 0.05). Gene expression levels in the ovaries returned to normal after transfer to BPA-free water, with HSP90 and CB normalizing by day 1, and CL by day 7.
These results indicate that even safe concentrations of BPA impose stress on the hepatopancreas and increase the expression of HSP90, CB, and CL genes in the ovaries, affecting ovarian development. And, these effects are reversible within a certain period after the removal of BPA.]]></description><subject>acute exposure</subject><subject>Acute lethal effect</subject><subject>Animals</subject><subject>antioxidant activity</subject><subject>antioxidant enzymes</subject><subject>Antioxidant reductase</subject><subject>Antioxidants - metabolism</subject><subject>Benzhydryl Compounds - toxicity</subject><subject>Bisphenol A</subject><subject>catalase</subject><subject>Catalase - genetics</subject><subject>Catalase - metabolism</subject><subject>Cathepsin B</subject><subject>Cathepsin L</subject><subject>chronic exposure</subject><subject>Endocrine Disruptors - toxicity</subject><subject>endocrine-disrupting chemicals</subject><subject>Female</subject><subject>gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Heat shock protein 90</subject><subject>hepatopancreas</subject><subject>Hepatopancreas - drug effects</subject><subject>Hepatopancreas - metabolism</subject><subject>HSP90 Heat-Shock Proteins - genetics</subject><subject>HSP90 Heat-Shock Proteins - metabolism</subject><subject>Macrobrachium nipponense</subject><subject>ovarian development</subject><subject>Ovary - drug effects</subject><subject>Ovary - metabolism</subject><subject>Palaemonidae - drug effects</subject><subject>Palaemonidae - genetics</subject><subject>Phenols - toxicity</subject><subject>rivers</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - genetics</subject><subject>Superoxide Dismutase - metabolism</subject><subject>toxicology</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0166-445X</issn><issn>1879-1514</issn><issn>1879-1514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd2O0zAQhS0EYsvCI4B8uUik2I6dpNyslhU_Ky0CCZC4s6bOmLpqbK-dlPJUvCKOWrgF34w0-s6Z8RxCnnK25Iw3L7dLuJtgDIelYEKWXstZfY8seNeuKq64vE8WhWsqKdW3M_Io5y0rT8jVQ3JWr2qmimBBfn0Gi9QEb9CPCUYX_As6-Tx30Vo0Y35Fb4YIZqTB0tefrmjwFHwBD64vldrJm1lGnafjBukGY1krgjcJIRe0p2EPyYGn39EX10NMmPNJEZIrg2FHk9tjojHBD5_pxQcwKawTmI2bBupdjMGjz_j8MXlgYZfxyamek69v33y5fl_dfnx3c311WxnRNmPFgXEju7ozBpTtDBestqhMp9pWKGhkpwRrOFfrnoGVDXLVib5wvOMNF7I-JxdH35jC3YR51IPLBnc78BimrGuupFCqsP-BsrbtpJCzqzqi5Xc5J7Q6JjdA-qk503OseqtPseo5Vn2MteienUZM6wH7v6o_ORbg8ghgucneYdLZlMMa7F0qGeo-uH-M-A0CmbiJ</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Zhao, Weihong</creator><creator>Zheng, Xirui</creator><creator>Jiang, Fengjuan</creator><creator>Liu, Jintao</creator><creator>Wang, Shuhao</creator><creator>Ou, Jiangtao</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202411</creationdate><title>Safe concentration, unsafe effects: Impact of BPA on antioxidant function in the hepatopancreas and ovarian gene expression in oriental river prawns (Macrobrachium nipponense)</title><author>Zhao, Weihong ; Zheng, Xirui ; Jiang, Fengjuan ; Liu, Jintao ; Wang, Shuhao ; Ou, Jiangtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-1a01c4838cca5f8c1203fe5c857725a6485206115bd0af46e1582d8c118161243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>acute exposure</topic><topic>Acute lethal effect</topic><topic>Animals</topic><topic>antioxidant activity</topic><topic>antioxidant enzymes</topic><topic>Antioxidant reductase</topic><topic>Antioxidants - metabolism</topic><topic>Benzhydryl Compounds - toxicity</topic><topic>Bisphenol A</topic><topic>catalase</topic><topic>Catalase - genetics</topic><topic>Catalase - metabolism</topic><topic>Cathepsin B</topic><topic>Cathepsin L</topic><topic>chronic exposure</topic><topic>Endocrine Disruptors - toxicity</topic><topic>endocrine-disrupting chemicals</topic><topic>Female</topic><topic>gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Heat shock protein 90</topic><topic>hepatopancreas</topic><topic>Hepatopancreas - drug effects</topic><topic>Hepatopancreas - metabolism</topic><topic>HSP90 Heat-Shock Proteins - genetics</topic><topic>HSP90 Heat-Shock Proteins - metabolism</topic><topic>Macrobrachium nipponense</topic><topic>ovarian development</topic><topic>Ovary - drug effects</topic><topic>Ovary - metabolism</topic><topic>Palaemonidae - drug effects</topic><topic>Palaemonidae - genetics</topic><topic>Phenols - toxicity</topic><topic>rivers</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - genetics</topic><topic>Superoxide Dismutase - metabolism</topic><topic>toxicology</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Weihong</creatorcontrib><creatorcontrib>Zheng, Xirui</creatorcontrib><creatorcontrib>Jiang, Fengjuan</creatorcontrib><creatorcontrib>Liu, Jintao</creatorcontrib><creatorcontrib>Wang, Shuhao</creatorcontrib><creatorcontrib>Ou, Jiangtao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Aquatic toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Weihong</au><au>Zheng, Xirui</au><au>Jiang, Fengjuan</au><au>Liu, Jintao</au><au>Wang, Shuhao</au><au>Ou, Jiangtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safe concentration, unsafe effects: Impact of BPA on antioxidant function in the hepatopancreas and ovarian gene expression in oriental river prawns (Macrobrachium nipponense)</atitle><jtitle>Aquatic toxicology</jtitle><addtitle>Aquat Toxicol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>276</volume><spage>107103</spage><pages>107103-</pages><artnum>107103</artnum><issn>0166-445X</issn><issn>1879-1514</issn><eissn>1879-1514</eissn><abstract><![CDATA[•The 24hLC50 and 48hLC50 of BPA for M. nipponense are 80.59 and 63.90 mg/L.•BPA enhances ovarian gene expression, causing precocious puberty and miniaturization.•Even safe-level BPA causes oxidative stress, affecting ovarian development.•The biological damage caused by BPA is reversible.
This study investigated the effects of Bisphenol A (BPA), a common endocrine-disrupting chemical, on the antioxidant enzyme activities in the hepatopancreas and the expression of genes related to ovarian development in oriental river prawns (Macrobrachium nipponense). The 24hLC50 and 48hLC50 values for BPA were 80.59 mg/L and 63.90 mg/L, respectively, with a safe concentration of 12.06 mg/L. Prawns were exposed to low (4.85 mg/L), safe (12.06 mg/L), and high (30.00 mg/L) concentrations of BPA for 10 days to measure enzyme activities, and for 20 days followed by 7 days in BPA-free water to measure gene expression.
Short-term exposure (12 h, 1d, 3d) to low concentration BPA did not significantly affect superoxide dismutase (SOD) activity in the hepatopancreas (P > 0.05), but long-term exposure (6d, 10d) significantly reduced SOD activity (P < 0.05). Catalase (CAT) activity showed no significant changes throughout the low concentration exposure period (P > 0.05). At safe and high concentrations, SOD and CAT activities significantly decreased after 12 h of exposure (P < 0.05).
BPA affected heat shock protein 90 (HSP90) expression in the ovary, with low concentration BPA significantly upregulating HSP90 after 1 day (P < 0.05), but returning to normal levels after 10 and 20 days. At the safe concentration, HSP90 was significantly upregulated at all three sampling points (1d, 10d, 20d) (P < 0.05), while high concentration exposure led to significant upregulation only on day 10 (P < 0.05).
Low concentration BPA had no significant effect on Cathepsin B (CB) and Cathepsin L (CL) gene expression in the ovaries (P > 0.05). However, safe concentration exposure promoted CB expression on days 1, 10, and 20 (P < 0.05), while high concentration exposure significantly increased CB expression on day 1 (P < 0.05), with levels returning to normal on days 10 and 20. CL expression significantly increased after 20 days of exposure to both safe and high concentrations (P < 0.05). Gene expression levels in the ovaries returned to normal after transfer to BPA-free water, with HSP90 and CB normalizing by day 1, and CL by day 7.
These results indicate that even safe concentrations of BPA impose stress on the hepatopancreas and increase the expression of HSP90, CB, and CL genes in the ovaries, affecting ovarian development. And, these effects are reversible within a certain period after the removal of BPA.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39305710</pmid><doi>10.1016/j.aquatox.2024.107103</doi></addata></record> |
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| subjects | acute exposure Acute lethal effect Animals antioxidant activity antioxidant enzymes Antioxidant reductase Antioxidants - metabolism Benzhydryl Compounds - toxicity Bisphenol A catalase Catalase - genetics Catalase - metabolism Cathepsin B Cathepsin L chronic exposure Endocrine Disruptors - toxicity endocrine-disrupting chemicals Female gene expression Gene Expression Regulation - drug effects Heat shock protein 90 hepatopancreas Hepatopancreas - drug effects Hepatopancreas - metabolism HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Macrobrachium nipponense ovarian development Ovary - drug effects Ovary - metabolism Palaemonidae - drug effects Palaemonidae - genetics Phenols - toxicity rivers superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism toxicology Water Pollutants, Chemical - toxicity |
| title | Safe concentration, unsafe effects: Impact of BPA on antioxidant function in the hepatopancreas and ovarian gene expression in oriental river prawns (Macrobrachium nipponense) |
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