GRP78 exerts antiviral function against influenza A virus infection by activating the IFN/JAK-STAT signaling

Influenza is an acute viral respiratory infection that causes mild to severe illness in humans and animals. Current studies show that glucose-regulated protein 78 (GRP78) can exert crucial functions during viral infection; however, the mechanism by which GRP78 regulates influenza A virus (IAV) infec...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2024-12, Vol.600, p.110249, Article 110249
Hauptverfasser:	Liu, Jiaxin, Chen, Kanghong, Wu, Wenjiao, Pang, Zefen, Zhu, Dandong, Yan, Xiukui, Wang, Bangqi, Qiu, Jianxiang, Fang, Zhixin
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Antiviral Endoplasmic Reticulum Chaperone BiP - metabolism GRP78 Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Host-Pathogen Interactions - immunology Humans Immunity, Innate Influenza A virus Influenza A virus - immunology Influenza A virus - physiology Influenza, Human - genetics Influenza, Human - immunology Influenza, Human - metabolism Influenza, Human - virology Innate immunity Interferon Interferon Type I - genetics Interferon Type I - immunology Interferon Type I - metabolism Interferons - genetics Interferons - immunology Interferons - metabolism Janus Kinases - genetics Janus Kinases - metabolism Signal Transduction STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Virus Replication
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