Detection of lipid radicals generated via cerebral ischemia/reperfusion injury using a radiolabeled nitroxide probe

Reactive oxygen species generated via reperfusion cause lipid damage and induce lipid peroxidation, leading to cerebral ischemia/reperfusion injury and exacerbation of cerebral infarction. Lipid radicals are key molecules generated during lipid peroxidation. Therefore, understanding the spatiotempor...

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Veröffentlicht in:	Free radical biology & medicine 2024-11, Vol.224, p.678-684
Hauptverfasser:	Azuma, Risa, Yamasaki, Toshihide, Sano, Kohei, Mukai, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Brain - metabolism Brain - pathology Brain Ischemia - diagnostic imaging Brain Ischemia - metabolism Brain Ischemia - pathology Disease Models, Animal Free Radicals - chemistry Free Radicals - metabolism Infarction, Middle Cerebral Artery - diagnostic imaging Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Iodine Radioisotopes - chemistry Ischemia Lipid Peroxidation Lipid radical Lipids - chemistry Male MCAO Mice Nitrogen Oxides - chemistry Nitrogen Oxides - metabolism Nuclear medical imaging Radioisotope Rats Reactive oxygen species Reactive Oxygen Species - metabolism Reperfusion Reperfusion Injury - diagnostic imaging Reperfusion Injury - metabolism Reperfusion Injury - pathology
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