Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest

Cerebral complications after cardiac arrest (CA) remain a major problem worldwide. The aim was to test the effects of sodium-ß-hydroxybutyrate (SBHB) infusion on brain injury in a clinically relevant swine model of CA. CA was electrically induced in 20 adult swine. After 10 min, cardiopulmonary resu...

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Veröffentlicht in:	Critical care (London, England) England), 2024-09, Vol.28 (1), p.314, Article 314
Hauptverfasser:	Annoni, Filippo, Su, Fuhong, Peluso, Lorenzo, Lisi, Ilaria, Caruso, Enrico, Pischiutta, Francesca, Gouvea Bogossian, Elisa, Garcia, Bruno, Njimi, Hassane, Vincent, Jean-Louis, Gaspard, Nicolas, Ferlini, Lorenzo, Creteur, Jacques, Zanier, Elisa R, Taccone, Fabio Silvio
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - blood Animals Biological markers Biomarkers - analysis Biomarkers - blood Brain Brain Injuries - drug therapy Cardiac arrest Cardiopulmonary Resuscitation - methods Dextrose Disease Models, Animal Glucose Glucose metabolism Heart Arrest - complications Heart Arrest - drug therapy Heart Arrest - therapy Injuries Male Neurons Neurophysiology Sodium Oxybate - administration & dosage Sodium Oxybate - pharmacology Sodium Oxybate - therapeutic use Swine
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