Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest
Cerebral complications after cardiac arrest (CA) remain a major problem worldwide. The aim was to test the effects of sodium-ß-hydroxybutyrate (SBHB) infusion on brain injury in a clinically relevant swine model of CA. CA was electrically induced in 20 adult swine. After 10 min, cardiopulmonary resu...
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| Veröffentlicht in: | Critical care (London, England) England), 2024-09, Vol.28 (1), p.314, Article 314 |
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| creator | Annoni, Filippo Su, Fuhong Peluso, Lorenzo Lisi, Ilaria Caruso, Enrico Pischiutta, Francesca Gouvea Bogossian, Elisa Garcia, Bruno Njimi, Hassane Vincent, Jean-Louis Gaspard, Nicolas Ferlini, Lorenzo Creteur, Jacques Zanier, Elisa R Taccone, Fabio Silvio |
| description | Cerebral complications after cardiac arrest (CA) remain a major problem worldwide. The aim was to test the effects of sodium-ß-hydroxybutyrate (SBHB) infusion on brain injury in a clinically relevant swine model of CA.
CA was electrically induced in 20 adult swine. After 10 min, cardiopulmonary resuscitation was performed for 5 min. After return of spontaneous circulation (ROSC), the animals were randomly assigned to receive an infusion of balanced crystalloid (controls, n = 11) or SBHB (theoretical osmolarity 1189 mOsm/l, n = 8) for 12 h. Multimodal neurological and cardiovascular monitoring were implemented in all animals. Nineteen of the 20 animals achieved ROSC. Blood sodium concentrations, osmolarity and circulating KBs were higher in the treated animals than in the controls. SBHB infusion was associated with significantly lower plasma biomarkers of brain injury at 6 (glial fibrillary acid protein, GFAP and neuron specific enolase, NSE) and 12 h (neurofilament light chain, NFL, GFAP and NSE) compared to controls. The amplitude of the stereoelectroencephalograph (sEEG) increased in treated animals after ROSC compared to controls. Cerebral glucose uptake was lower in treated animals.
In this experimental model, SBHB infusion after resuscitated CA was associated with reduced circulating markers of cerebral injury and increased sEEG amplitude. |
| doi_str_mv | 10.1186/s13054-024-05106-8 |
| format | Article |
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CA was electrically induced in 20 adult swine. After 10 min, cardiopulmonary resuscitation was performed for 5 min. After return of spontaneous circulation (ROSC), the animals were randomly assigned to receive an infusion of balanced crystalloid (controls, n = 11) or SBHB (theoretical osmolarity 1189 mOsm/l, n = 8) for 12 h. Multimodal neurological and cardiovascular monitoring were implemented in all animals. Nineteen of the 20 animals achieved ROSC. Blood sodium concentrations, osmolarity and circulating KBs were higher in the treated animals than in the controls. SBHB infusion was associated with significantly lower plasma biomarkers of brain injury at 6 (glial fibrillary acid protein, GFAP and neuron specific enolase, NSE) and 12 h (neurofilament light chain, NFL, GFAP and NSE) compared to controls. The amplitude of the stereoelectroencephalograph (sEEG) increased in treated animals after ROSC compared to controls. Cerebral glucose uptake was lower in treated animals.
In this experimental model, SBHB infusion after resuscitated CA was associated with reduced circulating markers of cerebral injury and increased sEEG amplitude.</description><identifier>ISSN: 1364-8535</identifier><identifier>ISSN: 1466-609X</identifier><identifier>EISSN: 1466-609X</identifier><identifier>EISSN: 1364-8535</identifier><identifier>DOI: 10.1186/s13054-024-05106-8</identifier><identifier>PMID: 39304944</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>3-Hydroxybutyric Acid - blood ; Animals ; Biological markers ; Biomarkers - analysis ; Biomarkers - blood ; Brain ; Brain Injuries - drug therapy ; Cardiac arrest ; Cardiopulmonary Resuscitation - methods ; Dextrose ; Disease Models, Animal ; Glucose ; Glucose metabolism ; Heart Arrest - complications ; Heart Arrest - drug therapy ; Heart Arrest - therapy ; Injuries ; Male ; Neurons ; Neurophysiology ; Sodium Oxybate - administration & dosage ; Sodium Oxybate - pharmacology ; Sodium Oxybate - therapeutic use ; Swine</subject><ispartof>Critical care (London, England), 2024-09, Vol.28 (1), p.314, Article 314</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c295t-275f54d6688e6e5d8657e7fa4fed6bb2a5494762f868483c5d96e3a01b91820c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39304944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Annoni, Filippo</creatorcontrib><creatorcontrib>Su, Fuhong</creatorcontrib><creatorcontrib>Peluso, Lorenzo</creatorcontrib><creatorcontrib>Lisi, Ilaria</creatorcontrib><creatorcontrib>Caruso, Enrico</creatorcontrib><creatorcontrib>Pischiutta, Francesca</creatorcontrib><creatorcontrib>Gouvea Bogossian, Elisa</creatorcontrib><creatorcontrib>Garcia, Bruno</creatorcontrib><creatorcontrib>Njimi, Hassane</creatorcontrib><creatorcontrib>Vincent, Jean-Louis</creatorcontrib><creatorcontrib>Gaspard, Nicolas</creatorcontrib><creatorcontrib>Ferlini, Lorenzo</creatorcontrib><creatorcontrib>Creteur, Jacques</creatorcontrib><creatorcontrib>Zanier, Elisa R</creatorcontrib><creatorcontrib>Taccone, Fabio Silvio</creatorcontrib><title>Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest</title><title>Critical care (London, England)</title><addtitle>Crit Care</addtitle><description>Cerebral complications after cardiac arrest (CA) remain a major problem worldwide. The aim was to test the effects of sodium-ß-hydroxybutyrate (SBHB) infusion on brain injury in a clinically relevant swine model of CA.
CA was electrically induced in 20 adult swine. After 10 min, cardiopulmonary resuscitation was performed for 5 min. After return of spontaneous circulation (ROSC), the animals were randomly assigned to receive an infusion of balanced crystalloid (controls, n = 11) or SBHB (theoretical osmolarity 1189 mOsm/l, n = 8) for 12 h. Multimodal neurological and cardiovascular monitoring were implemented in all animals. Nineteen of the 20 animals achieved ROSC. Blood sodium concentrations, osmolarity and circulating KBs were higher in the treated animals than in the controls. SBHB infusion was associated with significantly lower plasma biomarkers of brain injury at 6 (glial fibrillary acid protein, GFAP and neuron specific enolase, NSE) and 12 h (neurofilament light chain, NFL, GFAP and NSE) compared to controls. The amplitude of the stereoelectroencephalograph (sEEG) increased in treated animals after ROSC compared to controls. Cerebral glucose uptake was lower in treated animals.
In this experimental model, SBHB infusion after resuscitated CA was associated with reduced circulating markers of cerebral injury and increased sEEG amplitude.</description><subject>3-Hydroxybutyric Acid - blood</subject><subject>Animals</subject><subject>Biological markers</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>Brain</subject><subject>Brain Injuries - drug therapy</subject><subject>Cardiac arrest</subject><subject>Cardiopulmonary Resuscitation - methods</subject><subject>Dextrose</subject><subject>Disease Models, Animal</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Heart Arrest - complications</subject><subject>Heart Arrest - drug therapy</subject><subject>Heart Arrest - therapy</subject><subject>Injuries</subject><subject>Male</subject><subject>Neurons</subject><subject>Neurophysiology</subject><subject>Sodium Oxybate - administration & dosage</subject><subject>Sodium Oxybate - pharmacology</subject><subject>Sodium Oxybate - therapeutic use</subject><subject>Swine</subject><issn>1364-8535</issn><issn>1466-609X</issn><issn>1466-609X</issn><issn>1364-8535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc9qFTEUhwdRbK2-gAsJuHGTmv-TWZaqtXDBjYK7kElONHVmck0y0Nn6Ij6ML9ZcbxUECSEhfN85SX5d95ySc0q1el0oJ1JgwtqUlCisH3SnVCiFFRk-P2x7rgTWksuT7kkpN4TQXiv-uDvhAydiEOK0-3G9hLXEtKAUUEk-rjN6s8Mc__qJv24-p9ttXOuWbQXkwWWwBQpykGHMdkJxuVnzhsaYZpu_QS7IhgoZZShrcbHaeigdFwS3e8hxhqU2y9nso3XI5sbVp92jYKcCz-7Xs-7Tu7cfL9_j3Yer68uLHXZskBWzXgYpvFJagwLptZI99MGKAF6NI7OyvahXLGilheZO-kEBt4SOA9WMOH7WvTrW3ef0fW2NzRyLg2myC6S1GE5JL4kclGjoyyP6xU5g4hJSzdYdcHOhySCYZMOBOv8P1YaHObq0QIjt_B-BHQWXUykZgtm3P7F5M5SYQ6TmGKlpkZrfkRrdpBf3117HGfxf5U-G_A4Cm54H</recordid><startdate>20240920</startdate><enddate>20240920</enddate><creator>Annoni, Filippo</creator><creator>Su, Fuhong</creator><creator>Peluso, Lorenzo</creator><creator>Lisi, Ilaria</creator><creator>Caruso, Enrico</creator><creator>Pischiutta, Francesca</creator><creator>Gouvea Bogossian, Elisa</creator><creator>Garcia, Bruno</creator><creator>Njimi, Hassane</creator><creator>Vincent, Jean-Louis</creator><creator>Gaspard, Nicolas</creator><creator>Ferlini, Lorenzo</creator><creator>Creteur, Jacques</creator><creator>Zanier, Elisa R</creator><creator>Taccone, Fabio Silvio</creator><general>BioMed Central Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240920</creationdate><title>Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest</title><author>Annoni, Filippo ; Su, Fuhong ; Peluso, Lorenzo ; Lisi, Ilaria ; Caruso, Enrico ; Pischiutta, Francesca ; Gouvea Bogossian, Elisa ; Garcia, Bruno ; Njimi, Hassane ; Vincent, Jean-Louis ; Gaspard, Nicolas ; Ferlini, Lorenzo ; Creteur, Jacques ; Zanier, Elisa R ; Taccone, Fabio Silvio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c295t-275f54d6688e6e5d8657e7fa4fed6bb2a5494762f868483c5d96e3a01b91820c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>3-Hydroxybutyric Acid - blood</topic><topic>Animals</topic><topic>Biological markers</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>Brain</topic><topic>Brain Injuries - drug therapy</topic><topic>Cardiac arrest</topic><topic>Cardiopulmonary Resuscitation - methods</topic><topic>Dextrose</topic><topic>Disease Models, Animal</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Heart Arrest - complications</topic><topic>Heart Arrest - drug therapy</topic><topic>Heart Arrest - therapy</topic><topic>Injuries</topic><topic>Male</topic><topic>Neurons</topic><topic>Neurophysiology</topic><topic>Sodium Oxybate - administration & dosage</topic><topic>Sodium Oxybate - pharmacology</topic><topic>Sodium Oxybate - therapeutic use</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Annoni, Filippo</creatorcontrib><creatorcontrib>Su, Fuhong</creatorcontrib><creatorcontrib>Peluso, Lorenzo</creatorcontrib><creatorcontrib>Lisi, Ilaria</creatorcontrib><creatorcontrib>Caruso, Enrico</creatorcontrib><creatorcontrib>Pischiutta, Francesca</creatorcontrib><creatorcontrib>Gouvea Bogossian, Elisa</creatorcontrib><creatorcontrib>Garcia, Bruno</creatorcontrib><creatorcontrib>Njimi, Hassane</creatorcontrib><creatorcontrib>Vincent, Jean-Louis</creatorcontrib><creatorcontrib>Gaspard, Nicolas</creatorcontrib><creatorcontrib>Ferlini, Lorenzo</creatorcontrib><creatorcontrib>Creteur, Jacques</creatorcontrib><creatorcontrib>Zanier, Elisa R</creatorcontrib><creatorcontrib>Taccone, Fabio Silvio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Annoni, Filippo</au><au>Su, Fuhong</au><au>Peluso, Lorenzo</au><au>Lisi, Ilaria</au><au>Caruso, Enrico</au><au>Pischiutta, Francesca</au><au>Gouvea Bogossian, Elisa</au><au>Garcia, Bruno</au><au>Njimi, Hassane</au><au>Vincent, Jean-Louis</au><au>Gaspard, Nicolas</au><au>Ferlini, Lorenzo</au><au>Creteur, Jacques</au><au>Zanier, Elisa R</au><au>Taccone, Fabio Silvio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest</atitle><jtitle>Critical care (London, England)</jtitle><addtitle>Crit Care</addtitle><date>2024-09-20</date><risdate>2024</risdate><volume>28</volume><issue>1</issue><spage>314</spage><pages>314-</pages><artnum>314</artnum><issn>1364-8535</issn><issn>1466-609X</issn><eissn>1466-609X</eissn><eissn>1364-8535</eissn><abstract>Cerebral complications after cardiac arrest (CA) remain a major problem worldwide. The aim was to test the effects of sodium-ß-hydroxybutyrate (SBHB) infusion on brain injury in a clinically relevant swine model of CA.
CA was electrically induced in 20 adult swine. After 10 min, cardiopulmonary resuscitation was performed for 5 min. After return of spontaneous circulation (ROSC), the animals were randomly assigned to receive an infusion of balanced crystalloid (controls, n = 11) or SBHB (theoretical osmolarity 1189 mOsm/l, n = 8) for 12 h. Multimodal neurological and cardiovascular monitoring were implemented in all animals. Nineteen of the 20 animals achieved ROSC. Blood sodium concentrations, osmolarity and circulating KBs were higher in the treated animals than in the controls. SBHB infusion was associated with significantly lower plasma biomarkers of brain injury at 6 (glial fibrillary acid protein, GFAP and neuron specific enolase, NSE) and 12 h (neurofilament light chain, NFL, GFAP and NSE) compared to controls. The amplitude of the stereoelectroencephalograph (sEEG) increased in treated animals after ROSC compared to controls. Cerebral glucose uptake was lower in treated animals.
In this experimental model, SBHB infusion after resuscitated CA was associated with reduced circulating markers of cerebral injury and increased sEEG amplitude.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39304944</pmid><doi>10.1186/s13054-024-05106-8</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | 3-Hydroxybutyric Acid - blood Animals Biological markers Biomarkers - analysis Biomarkers - blood Brain Brain Injuries - drug therapy Cardiac arrest Cardiopulmonary Resuscitation - methods Dextrose Disease Models, Animal Glucose Glucose metabolism Heart Arrest - complications Heart Arrest - drug therapy Heart Arrest - therapy Injuries Male Neurons Neurophysiology Sodium Oxybate - administration & dosage Sodium Oxybate - pharmacology Sodium Oxybate - therapeutic use Swine |
| title | Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest |
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