Deep-Learning-Driven Discovery of SN3–1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases

The NLRP3 inflammasome plays a central role in the pathogenesis of various intractable human diseases, making it an urgent target for therapeutic intervention. Here, we report the development of SN3–1, a novel orally potent NLRP3 inhibitor, designed through a lead compound strategy centered on deep-...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-10, Vol.67 (19), p.17833-17854
Hauptverfasser:	Shi, Cheng, Gao, Tongfei, Lyu, Weiping, Qiang, Bo, Chen, Yanming, Chen, Qixuan, Zhang, Liangren, Liu, Zhenming
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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