Deciphering the spatial distribution of Gli1-lineage cells in dental, oral, and craniofacial regions
The craniofacial bone, crucial for protecting brain tissue and supporting facial structure, undergoes continuous remodeling through mesenchymal (MSCs) or skeletal stem cells in their niches. Gli1 is an ideal marker for labeling MSCs and osteoprogenitors in this region, and Gli1-lineage cells are ide...
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| Veröffentlicht in: | Journal of bone and mineral research 2024-11, Vol.39 (12), p.1809-1820 |
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| container_title | Journal of bone and mineral research |
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| creator | Li, Bo Ding, Zhangfan Ouchi, Takehito Liao, Yueqi Li, Bingzhi Gong, Jiajing Xie, Yuhang Zhao, Zhihe Li, Longjiang |
| description | The craniofacial bone, crucial for protecting brain tissue and supporting facial structure, undergoes continuous remodeling through mesenchymal (MSCs) or skeletal stem cells in their niches. Gli1 is an ideal marker for labeling MSCs and osteoprogenitors in this region, and Gli1-lineage cells are identified as pivotal for bone growth, development, repair, and regeneration. Despite its significance, the distribution of Gli1-lineage cells across the dental, oral, and craniofacial (DOC) regions remains to be systematically explored. Utilizing tissue-clearing and light sheet fluorescence microscopy with a Gli1CreER; tdTomatoAi14 mouse model, we mapped the spatial distribution of Gli1-lineage cells throughout the skull, focusing on calvarial bones, sutures, bone marrow, teeth, periodontium, jaw bones, and the temporomandibular joint. We found Gli1-lineage cells widespread in these areas, underscoring their significance in DOC regions. Additionally, we observed their role in repairing calvarial bone defects, providing novel insights into craniofacial biology and stem cell niches and enhancing our understanding of stem cells and their progeny's behavior in vivo. |
| doi_str_mv | 10.1093/jbmr/zjae152 |
| format | Article |
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Gli1 is an ideal marker for labeling MSCs and osteoprogenitors in this region, and Gli1-lineage cells are identified as pivotal for bone growth, development, repair, and regeneration. Despite its significance, the distribution of Gli1-lineage cells across the dental, oral, and craniofacial (DOC) regions remains to be systematically explored. Utilizing tissue-clearing and light sheet fluorescence microscopy with a Gli1CreER; tdTomatoAi14 mouse model, we mapped the spatial distribution of Gli1-lineage cells throughout the skull, focusing on calvarial bones, sutures, bone marrow, teeth, periodontium, jaw bones, and the temporomandibular joint. We found Gli1-lineage cells widespread in these areas, underscoring their significance in DOC regions. Additionally, we observed their role in repairing calvarial bone defects, providing novel insights into craniofacial biology and stem cell niches and enhancing our understanding of stem cells and their progeny's behavior in vivo.</description><identifier>ISSN: 0884-0431</identifier><identifier>ISSN: 1523-4681</identifier><identifier>EISSN: 1523-4681</identifier><identifier>DOI: 10.1093/jbmr/zjae152</identifier><identifier>PMID: 39303104</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Cell Lineage ; Facial Bones - metabolism ; Mice ; Mouth - metabolism ; Skull - metabolism ; Tooth - metabolism ; Zinc Finger Protein GLI1 - metabolism</subject><ispartof>Journal of bone and mineral research, 2024-11, Vol.39 (12), p.1809-1820</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. All rights reserved. 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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Cell Lineage Facial Bones - metabolism Mice Mouth - metabolism Skull - metabolism Tooth - metabolism Zinc Finger Protein GLI1 - metabolism |
| title | Deciphering the spatial distribution of Gli1-lineage cells in dental, oral, and craniofacial regions |
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