The prognostic value of HALP score and sPESI in predicting in-hospital mortality in patients with pulmonary thromboembolism
Pulmonary thromboembolism (PTE), often arising from deep vein thrombosis, remains a high-mortality condition despite diagnostic advancements. Prognostic models like Pulmonary Embolism Severity Index (PESI) and sPESI identify low-risk groups effectively. The Hemoglobin, Albumin, Lymphocyte, and Plate...
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| Veröffentlicht in: | Postgraduate medical journal 2024-12, Vol.101 (1191), p.60-65 |
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| creator | Yaman, Mahmut Orak, Murat Durgun, Hasan Mansur Tekin, Veysi Ülgüt, Şilan Göger Belek, Sema Günel, Berçem Tugay Üstündağ, Mehmet Güloğlu, Cahfer Gündüz, Ercan |
| description | Pulmonary thromboembolism (PTE), often arising from deep vein thrombosis, remains a high-mortality condition despite diagnostic advancements. Prognostic models like Pulmonary Embolism Severity Index (PESI) and sPESI identify low-risk groups effectively. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, reflecting nutritional status and systemic inflammation, shows prognostic value in cancers and cardiovascular diseases. This study examines the relationship between in-hospital mortality HALP score and simplified PESI (sPESI) in PTE patients.
This retrospective observational study included patients diagnosed with PTE in the emergency department of a tertiary medical faculty from 2018 to 2023. PTE diagnosis was confirmed via computed tomography pulmonary angiography. Data on transthoracic echocardiography, D-dimer levels, demographics, laboratory results, PESI, sPESI, and HALP scores, and in-hospital mortality were collected.
In this study, clinical characteristics of 171 patients with PTE were analysed. The average age was 61.88 ± 19.94 years, and 53.2% were female. Mortality was observed in 19.3% of patients. PESI and sPESI scores were significant predictors of mortality, with area under the curve values of 0.938 and 0.879, respectively. PESI score > 175.50 indicated a significantly higher mortality risk (HR = 18.208; P 2.50 was also a strong predictor (HR = 11.840; P |
| doi_str_mv | 10.1093/postmj/qgae124 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3107161934</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3107161934</sourcerecordid><originalsourceid>FETCH-LOGICAL-c180t-987db9720eb968160e594f1947fd21d88eef9f5dd730fdfad3d1b6e0000f254c3</originalsourceid><addsrcrecordid>eNo9kM1LxDAQxYMoun5cPUqOXqpJ0zbNUZbVFRZcUM8lbSbbSNvUJFUW_3mjuzowPAZ-85h5CF1SckOJYLej9aF_u33fSKBpdoBmNCtEQnheHKIZISxN8oyzE3Tq_RshlPGMHqMTJhihvBQz9PXSAh6d3QzRyDT4Q3YTYKvx8m61xr6xDrAcFPbrxfMjNkNkQZkmmGETp6S1fjRBdri3LooJ219GBgND8PjThBaPU9fbQbotDq2zfW0hdmd8f46OtOw8XOz1DL3eL17my2T19PA4v1slDS1JSETJVS14SqAWRUkLArnINBUZ1yqlqiwBtNC5UpwRrbRUTNG6ABJLp3nWsDN0vfONf75P4EPVG99A18kB7OQrRgmnBRUsi-jNDm2c9d6BrkZn-nh7RUn1E3i1C7zaBx4XrvbeU92D-sf_Embff6qBEQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3107161934</pqid></control><display><type>article</type><title>The prognostic value of HALP score and sPESI in predicting in-hospital mortality in patients with pulmonary thromboembolism</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><creator>Yaman, Mahmut ; Orak, Murat ; Durgun, Hasan Mansur ; Tekin, Veysi ; Ülgüt, Şilan Göger ; Belek, Sema ; Günel, Berçem Tugay ; Üstündağ, Mehmet ; Güloğlu, Cahfer ; Gündüz, Ercan</creator><creatorcontrib>Yaman, Mahmut ; Orak, Murat ; Durgun, Hasan Mansur ; Tekin, Veysi ; Ülgüt, Şilan Göger ; Belek, Sema ; Günel, Berçem Tugay ; Üstündağ, Mehmet ; Güloğlu, Cahfer ; Gündüz, Ercan</creatorcontrib><description>Pulmonary thromboembolism (PTE), often arising from deep vein thrombosis, remains a high-mortality condition despite diagnostic advancements. Prognostic models like Pulmonary Embolism Severity Index (PESI) and sPESI identify low-risk groups effectively. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, reflecting nutritional status and systemic inflammation, shows prognostic value in cancers and cardiovascular diseases. This study examines the relationship between in-hospital mortality HALP score and simplified PESI (sPESI) in PTE patients.
This retrospective observational study included patients diagnosed with PTE in the emergency department of a tertiary medical faculty from 2018 to 2023. PTE diagnosis was confirmed via computed tomography pulmonary angiography. Data on transthoracic echocardiography, D-dimer levels, demographics, laboratory results, PESI, sPESI, and HALP scores, and in-hospital mortality were collected.
In this study, clinical characteristics of 171 patients with PTE were analysed. The average age was 61.88 ± 19.94 years, and 53.2% were female. Mortality was observed in 19.3% of patients. PESI and sPESI scores were significant predictors of mortality, with area under the curve values of 0.938 and 0.879, respectively. PESI score > 175.50 indicated a significantly higher mortality risk (HR = 18.208; P < .001), while sPESI >2.50 was also a strong predictor (HR = 11.840; P < .001). No significant cut-off value for HALP in predicting mortality was identified.
Our study supports the reliability of sPESI and PESI scores in predicting in-hospital mortality in PTE patients. However, the prognostic value of the HALP score requires further investigation. Our findings highlight the need for developing risk stratification models. Key message What is already known on this topic? The PESI and sPESI scores are established prognostic models that effectively identify low-risk groups in patients with PTE. The HALP score, reflecting nutritional status and systemic inflammation, has shown prognostic value in cancer and cardiovascular diseases. What this study adds? This study demonstrates that while PESI and sPESI scores are significant predictors of in-hospital mortality in PTE patients, the HALP score does not have a significant cut-off value for predicting mortality. How this study might affect research, practice, or policy? The findings support the continued use of PESI and sPESI scores for risk stratification in clinical practice, potentially influencing guidelines and policies on managing PTE. Further research into the HALP score's role in other contexts may refine its prognostic utility.</description><identifier>ISSN: 0032-5473</identifier><identifier>ISSN: 1469-0756</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1093/postmj/qgae124</identifier><identifier>PMID: 39301789</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Female ; Hemoglobins - analysis ; Hemoglobins - metabolism ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Platelet Count ; Prognosis ; Pulmonary Embolism - blood ; Pulmonary Embolism - diagnosis ; Pulmonary Embolism - mortality ; Retrospective Studies ; Risk Assessment ; Serum Albumin - analysis ; Serum Albumin - metabolism ; Severity of Illness Index</subject><ispartof>Postgraduate medical journal, 2024-12, Vol.101 (1191), p.60-65</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of Fellowship of Postgraduate Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c180t-987db9720eb968160e594f1947fd21d88eef9f5dd730fdfad3d1b6e0000f254c3</cites><orcidid>0000-0002-5799-3985 ; 0000-0001-5209-5564 ; 0000-0002-0783-1419 ; 0000-0002-4681-8989 ; 0000-0002-0931-3359 ; 0000-0003-1100-3613 ; 0000-0001-5005-6369 ; 0000-0002-2581-476X ; 0000-0002-8102-6231</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39301789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yaman, Mahmut</creatorcontrib><creatorcontrib>Orak, Murat</creatorcontrib><creatorcontrib>Durgun, Hasan Mansur</creatorcontrib><creatorcontrib>Tekin, Veysi</creatorcontrib><creatorcontrib>Ülgüt, Şilan Göger</creatorcontrib><creatorcontrib>Belek, Sema</creatorcontrib><creatorcontrib>Günel, Berçem Tugay</creatorcontrib><creatorcontrib>Üstündağ, Mehmet</creatorcontrib><creatorcontrib>Güloğlu, Cahfer</creatorcontrib><creatorcontrib>Gündüz, Ercan</creatorcontrib><title>The prognostic value of HALP score and sPESI in predicting in-hospital mortality in patients with pulmonary thromboembolism</title><title>Postgraduate medical journal</title><addtitle>Postgrad Med J</addtitle><description>Pulmonary thromboembolism (PTE), often arising from deep vein thrombosis, remains a high-mortality condition despite diagnostic advancements. Prognostic models like Pulmonary Embolism Severity Index (PESI) and sPESI identify low-risk groups effectively. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, reflecting nutritional status and systemic inflammation, shows prognostic value in cancers and cardiovascular diseases. This study examines the relationship between in-hospital mortality HALP score and simplified PESI (sPESI) in PTE patients.
This retrospective observational study included patients diagnosed with PTE in the emergency department of a tertiary medical faculty from 2018 to 2023. PTE diagnosis was confirmed via computed tomography pulmonary angiography. Data on transthoracic echocardiography, D-dimer levels, demographics, laboratory results, PESI, sPESI, and HALP scores, and in-hospital mortality were collected.
In this study, clinical characteristics of 171 patients with PTE were analysed. The average age was 61.88 ± 19.94 years, and 53.2% were female. Mortality was observed in 19.3% of patients. PESI and sPESI scores were significant predictors of mortality, with area under the curve values of 0.938 and 0.879, respectively. PESI score > 175.50 indicated a significantly higher mortality risk (HR = 18.208; P < .001), while sPESI >2.50 was also a strong predictor (HR = 11.840; P < .001). No significant cut-off value for HALP in predicting mortality was identified.
Our study supports the reliability of sPESI and PESI scores in predicting in-hospital mortality in PTE patients. However, the prognostic value of the HALP score requires further investigation. Our findings highlight the need for developing risk stratification models. Key message What is already known on this topic? The PESI and sPESI scores are established prognostic models that effectively identify low-risk groups in patients with PTE. The HALP score, reflecting nutritional status and systemic inflammation, has shown prognostic value in cancer and cardiovascular diseases. What this study adds? This study demonstrates that while PESI and sPESI scores are significant predictors of in-hospital mortality in PTE patients, the HALP score does not have a significant cut-off value for predicting mortality. How this study might affect research, practice, or policy? The findings support the continued use of PESI and sPESI scores for risk stratification in clinical practice, potentially influencing guidelines and policies on managing PTE. Further research into the HALP score's role in other contexts may refine its prognostic utility.</description><subject>Aged</subject><subject>Female</subject><subject>Hemoglobins - analysis</subject><subject>Hemoglobins - metabolism</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet Count</subject><subject>Prognosis</subject><subject>Pulmonary Embolism - blood</subject><subject>Pulmonary Embolism - diagnosis</subject><subject>Pulmonary Embolism - mortality</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Serum Albumin - analysis</subject><subject>Serum Albumin - metabolism</subject><subject>Severity of Illness Index</subject><issn>0032-5473</issn><issn>1469-0756</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LxDAQxYMoun5cPUqOXqpJ0zbNUZbVFRZcUM8lbSbbSNvUJFUW_3mjuzowPAZ-85h5CF1SckOJYLej9aF_u33fSKBpdoBmNCtEQnheHKIZISxN8oyzE3Tq_RshlPGMHqMTJhihvBQz9PXSAh6d3QzRyDT4Q3YTYKvx8m61xr6xDrAcFPbrxfMjNkNkQZkmmGETp6S1fjRBdri3LooJ219GBgND8PjThBaPU9fbQbotDq2zfW0hdmd8f46OtOw8XOz1DL3eL17my2T19PA4v1slDS1JSETJVS14SqAWRUkLArnINBUZ1yqlqiwBtNC5UpwRrbRUTNG6ABJLp3nWsDN0vfONf75P4EPVG99A18kB7OQrRgmnBRUsi-jNDm2c9d6BrkZn-nh7RUn1E3i1C7zaBx4XrvbeU92D-sf_Embff6qBEQ</recordid><startdate>20241223</startdate><enddate>20241223</enddate><creator>Yaman, Mahmut</creator><creator>Orak, Murat</creator><creator>Durgun, Hasan Mansur</creator><creator>Tekin, Veysi</creator><creator>Ülgüt, Şilan Göger</creator><creator>Belek, Sema</creator><creator>Günel, Berçem Tugay</creator><creator>Üstündağ, Mehmet</creator><creator>Güloğlu, Cahfer</creator><creator>Gündüz, Ercan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5799-3985</orcidid><orcidid>https://orcid.org/0000-0001-5209-5564</orcidid><orcidid>https://orcid.org/0000-0002-0783-1419</orcidid><orcidid>https://orcid.org/0000-0002-4681-8989</orcidid><orcidid>https://orcid.org/0000-0002-0931-3359</orcidid><orcidid>https://orcid.org/0000-0003-1100-3613</orcidid><orcidid>https://orcid.org/0000-0001-5005-6369</orcidid><orcidid>https://orcid.org/0000-0002-2581-476X</orcidid><orcidid>https://orcid.org/0000-0002-8102-6231</orcidid></search><sort><creationdate>20241223</creationdate><title>The prognostic value of HALP score and sPESI in predicting in-hospital mortality in patients with pulmonary thromboembolism</title><author>Yaman, Mahmut ; Orak, Murat ; Durgun, Hasan Mansur ; Tekin, Veysi ; Ülgüt, Şilan Göger ; Belek, Sema ; Günel, Berçem Tugay ; Üstündağ, Mehmet ; Güloğlu, Cahfer ; Gündüz, Ercan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c180t-987db9720eb968160e594f1947fd21d88eef9f5dd730fdfad3d1b6e0000f254c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Female</topic><topic>Hemoglobins - analysis</topic><topic>Hemoglobins - metabolism</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Platelet Count</topic><topic>Prognosis</topic><topic>Pulmonary Embolism - blood</topic><topic>Pulmonary Embolism - diagnosis</topic><topic>Pulmonary Embolism - mortality</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Serum Albumin - analysis</topic><topic>Serum Albumin - metabolism</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yaman, Mahmut</creatorcontrib><creatorcontrib>Orak, Murat</creatorcontrib><creatorcontrib>Durgun, Hasan Mansur</creatorcontrib><creatorcontrib>Tekin, Veysi</creatorcontrib><creatorcontrib>Ülgüt, Şilan Göger</creatorcontrib><creatorcontrib>Belek, Sema</creatorcontrib><creatorcontrib>Günel, Berçem Tugay</creatorcontrib><creatorcontrib>Üstündağ, Mehmet</creatorcontrib><creatorcontrib>Güloğlu, Cahfer</creatorcontrib><creatorcontrib>Gündüz, Ercan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Postgraduate medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaman, Mahmut</au><au>Orak, Murat</au><au>Durgun, Hasan Mansur</au><au>Tekin, Veysi</au><au>Ülgüt, Şilan Göger</au><au>Belek, Sema</au><au>Günel, Berçem Tugay</au><au>Üstündağ, Mehmet</au><au>Güloğlu, Cahfer</au><au>Gündüz, Ercan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic value of HALP score and sPESI in predicting in-hospital mortality in patients with pulmonary thromboembolism</atitle><jtitle>Postgraduate medical journal</jtitle><addtitle>Postgrad Med J</addtitle><date>2024-12-23</date><risdate>2024</risdate><volume>101</volume><issue>1191</issue><spage>60</spage><epage>65</epage><pages>60-65</pages><issn>0032-5473</issn><issn>1469-0756</issn><eissn>1469-0756</eissn><abstract>Pulmonary thromboembolism (PTE), often arising from deep vein thrombosis, remains a high-mortality condition despite diagnostic advancements. Prognostic models like Pulmonary Embolism Severity Index (PESI) and sPESI identify low-risk groups effectively. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, reflecting nutritional status and systemic inflammation, shows prognostic value in cancers and cardiovascular diseases. This study examines the relationship between in-hospital mortality HALP score and simplified PESI (sPESI) in PTE patients.
This retrospective observational study included patients diagnosed with PTE in the emergency department of a tertiary medical faculty from 2018 to 2023. PTE diagnosis was confirmed via computed tomography pulmonary angiography. Data on transthoracic echocardiography, D-dimer levels, demographics, laboratory results, PESI, sPESI, and HALP scores, and in-hospital mortality were collected.
In this study, clinical characteristics of 171 patients with PTE were analysed. The average age was 61.88 ± 19.94 years, and 53.2% were female. Mortality was observed in 19.3% of patients. PESI and sPESI scores were significant predictors of mortality, with area under the curve values of 0.938 and 0.879, respectively. PESI score > 175.50 indicated a significantly higher mortality risk (HR = 18.208; P < .001), while sPESI >2.50 was also a strong predictor (HR = 11.840; P < .001). No significant cut-off value for HALP in predicting mortality was identified.
Our study supports the reliability of sPESI and PESI scores in predicting in-hospital mortality in PTE patients. However, the prognostic value of the HALP score requires further investigation. Our findings highlight the need for developing risk stratification models. Key message What is already known on this topic? The PESI and sPESI scores are established prognostic models that effectively identify low-risk groups in patients with PTE. The HALP score, reflecting nutritional status and systemic inflammation, has shown prognostic value in cancer and cardiovascular diseases. What this study adds? This study demonstrates that while PESI and sPESI scores are significant predictors of in-hospital mortality in PTE patients, the HALP score does not have a significant cut-off value for predicting mortality. How this study might affect research, practice, or policy? The findings support the continued use of PESI and sPESI scores for risk stratification in clinical practice, potentially influencing guidelines and policies on managing PTE. Further research into the HALP score's role in other contexts may refine its prognostic utility.</abstract><cop>England</cop><pmid>39301789</pmid><doi>10.1093/postmj/qgae124</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5799-3985</orcidid><orcidid>https://orcid.org/0000-0001-5209-5564</orcidid><orcidid>https://orcid.org/0000-0002-0783-1419</orcidid><orcidid>https://orcid.org/0000-0002-4681-8989</orcidid><orcidid>https://orcid.org/0000-0002-0931-3359</orcidid><orcidid>https://orcid.org/0000-0003-1100-3613</orcidid><orcidid>https://orcid.org/0000-0001-5005-6369</orcidid><orcidid>https://orcid.org/0000-0002-2581-476X</orcidid><orcidid>https://orcid.org/0000-0002-8102-6231</orcidid></addata></record> |
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| subjects | Aged Female Hemoglobins - analysis Hemoglobins - metabolism Hospital Mortality Humans Male Middle Aged Platelet Count Prognosis Pulmonary Embolism - blood Pulmonary Embolism - diagnosis Pulmonary Embolism - mortality Retrospective Studies Risk Assessment Serum Albumin - analysis Serum Albumin - metabolism Severity of Illness Index |
| title | The prognostic value of HALP score and sPESI in predicting in-hospital mortality in patients with pulmonary thromboembolism |
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