Laminar organization of visual responses in core and parabelt auditory cortex
Abstract Audiovisual (AV) interaction has been shown in many studies of auditory cortex. However, the underlying processes and circuits are unclear because few studies have used methods that delineate the timing and laminar distribution of net excitatory and inhibitory processes within areas, much l...
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Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2024-09, Vol.34 (9) |
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container_title | Cerebral cortex (New York, N.Y. 1991) |
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creator | Mackey, Chase A O’Connell, Monica N Hackett, Troy A Schroeder, Charles E Kajikawa, Yoshinao |
description | Abstract
Audiovisual (AV) interaction has been shown in many studies of auditory cortex. However, the underlying processes and circuits are unclear because few studies have used methods that delineate the timing and laminar distribution of net excitatory and inhibitory processes within areas, much less across cortical levels. This study examined laminar profiles of neuronal activity in auditory core (AC) and parabelt (PB) cortices recorded from macaques during active discrimination of conspecific faces and vocalizations. We found modulation of multi-unit activity (MUA) in response to isolated visual stimulation, characterized by a brief deep MUA spike, putatively in white matter, followed by mid-layer MUA suppression in core auditory cortex; the later suppressive event had clear current source density concomitants, while the earlier MUA spike did not. We observed a similar facilitation-suppression sequence in the PB, with later onset latency. In combined AV stimulation, there was moderate reduction of responses to sound during the visual-evoked MUA suppression interval in both AC and PB. These data suggest a common sequence of afferent spikes, followed by synaptic inhibition; however, differences in timing and laminar location may reflect distinct visual projections to AC and PB. |
doi_str_mv | 10.1093/cercor/bhae373 |
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Audiovisual (AV) interaction has been shown in many studies of auditory cortex. However, the underlying processes and circuits are unclear because few studies have used methods that delineate the timing and laminar distribution of net excitatory and inhibitory processes within areas, much less across cortical levels. This study examined laminar profiles of neuronal activity in auditory core (AC) and parabelt (PB) cortices recorded from macaques during active discrimination of conspecific faces and vocalizations. We found modulation of multi-unit activity (MUA) in response to isolated visual stimulation, characterized by a brief deep MUA spike, putatively in white matter, followed by mid-layer MUA suppression in core auditory cortex; the later suppressive event had clear current source density concomitants, while the earlier MUA spike did not. We observed a similar facilitation-suppression sequence in the PB, with later onset latency. In combined AV stimulation, there was moderate reduction of responses to sound during the visual-evoked MUA suppression interval in both AC and PB. These data suggest a common sequence of afferent spikes, followed by synaptic inhibition; however, differences in timing and laminar location may reflect distinct visual projections to AC and PB.</description><identifier>ISSN: 1047-3211</identifier><identifier>ISSN: 1460-2199</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhae373</identifier><identifier>PMID: 39300609</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Acoustic Stimulation - methods ; Action Potentials - physiology ; Animals ; Auditory Cortex - physiology ; Auditory Perception - physiology ; Female ; Macaca mulatta ; Male ; Neurons - physiology ; Photic Stimulation - methods ; Visual Perception - physiology ; Vocalization, Animal - physiology</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2024-09, Vol.34 (9)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c214t-6067c391356396af88436b6bd35a012e2a33bff81b119d067161f1d7a961a50b3</cites><orcidid>0000-0002-0403-9637</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39300609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mackey, Chase A</creatorcontrib><creatorcontrib>O’Connell, Monica N</creatorcontrib><creatorcontrib>Hackett, Troy A</creatorcontrib><creatorcontrib>Schroeder, Charles E</creatorcontrib><creatorcontrib>Kajikawa, Yoshinao</creatorcontrib><title>Laminar organization of visual responses in core and parabelt auditory cortex</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Abstract
Audiovisual (AV) interaction has been shown in many studies of auditory cortex. However, the underlying processes and circuits are unclear because few studies have used methods that delineate the timing and laminar distribution of net excitatory and inhibitory processes within areas, much less across cortical levels. This study examined laminar profiles of neuronal activity in auditory core (AC) and parabelt (PB) cortices recorded from macaques during active discrimination of conspecific faces and vocalizations. We found modulation of multi-unit activity (MUA) in response to isolated visual stimulation, characterized by a brief deep MUA spike, putatively in white matter, followed by mid-layer MUA suppression in core auditory cortex; the later suppressive event had clear current source density concomitants, while the earlier MUA spike did not. We observed a similar facilitation-suppression sequence in the PB, with later onset latency. In combined AV stimulation, there was moderate reduction of responses to sound during the visual-evoked MUA suppression interval in both AC and PB. These data suggest a common sequence of afferent spikes, followed by synaptic inhibition; however, differences in timing and laminar location may reflect distinct visual projections to AC and PB.</description><subject>Acoustic Stimulation - methods</subject><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Auditory Cortex - physiology</subject><subject>Auditory Perception - physiology</subject><subject>Female</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Neurons - physiology</subject><subject>Photic Stimulation - methods</subject><subject>Visual Perception - physiology</subject><subject>Vocalization, Animal - physiology</subject><issn>1047-3211</issn><issn>1460-2199</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqWwMiKPMKT1xYkTj6jiSypigTk6JzYYJXGwE0T59aRKYWW6k-5535MeQs6BLYFJviq1L51fqTfUPOMHZA6JYFEMUh6OO0uyiMcAM3ISwjtjkMVpfExmXHLGBJNz8rjBxrboqfOv2Npv7K1rqTP004YBa-p16FwbdKC2peMnTbGtaIcela57ikNle-e3u1Ovv07JkcE66LP9XJCX25vn9X20ebp7WF9vojKGpI8EE1nJJfBUcCnQ5HnChRKq4ikyiHWMnCtjclAAshphEGCgylAKwJQpviCXU2_n3cegQ180NpS6rrHVbggFB5ZBmgtIR3Q5oaV3IXhtis7bBv22AFbsFBaTwmKvcAxc7LsH1ejqD_91NgJXE-CG7r-yH3TufK8</recordid><startdate>20240903</startdate><enddate>20240903</enddate><creator>Mackey, Chase A</creator><creator>O’Connell, Monica N</creator><creator>Hackett, Troy A</creator><creator>Schroeder, Charles E</creator><creator>Kajikawa, Yoshinao</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0403-9637</orcidid></search><sort><creationdate>20240903</creationdate><title>Laminar organization of visual responses in core and parabelt auditory cortex</title><author>Mackey, Chase A ; O’Connell, Monica N ; Hackett, Troy A ; Schroeder, Charles E ; Kajikawa, Yoshinao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c214t-6067c391356396af88436b6bd35a012e2a33bff81b119d067161f1d7a961a50b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Auditory Cortex - physiology</topic><topic>Auditory Perception - physiology</topic><topic>Female</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Neurons - physiology</topic><topic>Photic Stimulation - methods</topic><topic>Visual Perception - physiology</topic><topic>Vocalization, Animal - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mackey, Chase A</creatorcontrib><creatorcontrib>O’Connell, Monica N</creatorcontrib><creatorcontrib>Hackett, Troy A</creatorcontrib><creatorcontrib>Schroeder, Charles E</creatorcontrib><creatorcontrib>Kajikawa, Yoshinao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mackey, Chase A</au><au>O’Connell, Monica N</au><au>Hackett, Troy A</au><au>Schroeder, Charles E</au><au>Kajikawa, Yoshinao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laminar organization of visual responses in core and parabelt auditory cortex</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2024-09-03</date><risdate>2024</risdate><volume>34</volume><issue>9</issue><issn>1047-3211</issn><issn>1460-2199</issn><eissn>1460-2199</eissn><abstract>Abstract
Audiovisual (AV) interaction has been shown in many studies of auditory cortex. However, the underlying processes and circuits are unclear because few studies have used methods that delineate the timing and laminar distribution of net excitatory and inhibitory processes within areas, much less across cortical levels. This study examined laminar profiles of neuronal activity in auditory core (AC) and parabelt (PB) cortices recorded from macaques during active discrimination of conspecific faces and vocalizations. We found modulation of multi-unit activity (MUA) in response to isolated visual stimulation, characterized by a brief deep MUA spike, putatively in white matter, followed by mid-layer MUA suppression in core auditory cortex; the later suppressive event had clear current source density concomitants, while the earlier MUA spike did not. We observed a similar facilitation-suppression sequence in the PB, with later onset latency. In combined AV stimulation, there was moderate reduction of responses to sound during the visual-evoked MUA suppression interval in both AC and PB. These data suggest a common sequence of afferent spikes, followed by synaptic inhibition; however, differences in timing and laminar location may reflect distinct visual projections to AC and PB.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>39300609</pmid><doi>10.1093/cercor/bhae373</doi><orcidid>https://orcid.org/0000-0002-0403-9637</orcidid></addata></record> |
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subjects | Acoustic Stimulation - methods Action Potentials - physiology Animals Auditory Cortex - physiology Auditory Perception - physiology Female Macaca mulatta Male Neurons - physiology Photic Stimulation - methods Visual Perception - physiology Vocalization, Animal - physiology |
title | Laminar organization of visual responses in core and parabelt auditory cortex |
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