Duodenal transcriptomics demonstrates signatures of tissue inflammation and immune cell infiltration in children with environmental enteric dysfunction across global centers

Environmental enteric dysfunction (EED) is an inflammatory condition of the small intestine that is prevalent in children residing in low- and middle-income countries. EED is accompanied by profound histopathologic changes in the small bowel, loss of absorptive capacity, increased intestinal permeab...

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Veröffentlicht in:	The American journal of clinical nutrition 2024-09, Vol.120, p.S51-S64
Hauptverfasser:	Marie, Chelsea, Das, Subhasish, Coomes, David, Ahmed, Tahmeed, Ali, S Asad, Iqbal, Junaid, Kelly, Paul, Mahfuz, Mustafa, Moore, Sean R, Petri, William A, Tarr, Phillip I, Denson, Lee A, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md Ashraful, Auble, David, Begum, SM Khodeza Nahar, Besa, Ellen, Chama, Mubanga, Denno, Donna M, Fahim, Shah Mohammad, Gazi, Md Amran, Haberman, Yael, Haque, Rashidul, Hasan, Md Mehedi, Hossain, Md Shabab, Hotwani, Aneeta, Iqbal, Najeeha Talat, Jan, Ning-Jiun, Kabir, Furqan, Kumar, Pankaj, Liu, Ta-Chiang, Mann, Barbara J, Mazumder, Ramendra Nath, Mohammad, Anwaruddin, Moskaluk, Christopher A, Nayak, Uma, Ndao, Malick, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Shaikh, Nurmohammad, Sullivan, Peter B, Tearney, Guillermo J, Umrani, Fayaz, Yilmaz, Omer H, Zyambo, Kanekwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptivity Antioxidants biopsy Chemokines Child Child, Preschool Children Cytokines Detoxification Down-regulation Duodenum - immunology Duodenum - metabolism Duodenum - pathology environmental enteric dysfunction environmental enteropathy Female Gene sequencing Genes Humans Immune response Immune system Infant Inflammation Inflammation - genetics Intestine Male Microorganisms Modules Network analysis Nutrient loss Pediatrics Prospective Studies RNA-sequencing Signatures Small intestine Transcriptome Transcriptomes Transcriptomics Translocation WGCNA
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