The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation

[Display omitted] •PD-L1 is upregulated during the transdifferentiation of fibroblasts into myofibroblasts and is mediated by the PI3K/AKT/mTOR pathway.•Upregulated PD-L1 in activated fibroblasts promotes activation of the PI3K/AKT/mTOR signaling through positive feedback.•Ubiquitin-proteasome-media...

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Veröffentlicht in:	International immunopharmacology 2024-12, Vol.142 (Pt B), p.113186, Article 113186
Hauptverfasser:	Zhao, Youliang, Qi, Yuanmeng, Xia, Jiarui, Duan, Meixiu, Hao, Changfu, Yao, Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Lung fibroblasts PD-L1 PI3K/AKT/mTOR pathway Silicosis Transdifferentiation
Online-Zugang:	Volltext
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