Early-life adversity severity, timing, and context type are associated with SLC6A4 methylation in emerging adults: Results from a prospective cohort study

Epigenetic modifications, including DNA methylation (DNAm), can play a role in the biological embedding of early-life adversity (ELA) through serotonergic mechanisms. The current study examines methylation of the CpG island in the promoter region of the stress-responsive serotonin transporter gene (...

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Veröffentlicht in:	Psychoneuroendocrinology 2024-12, Vol.170, p.107181, Article 107181
Hauptverfasser:	Koning, Stephanie M., Kessler, Courtenay L., Canli, Turhan, Duman, Elif A., Adam, Emma K., Zinbarg, Richard, Craske, Michelle G., Stephens, Jacquelyn E., Vrshek-Schallhorn, Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adverse Childhood Experiences Child CpG Islands - genetics Deprivation DNA methylation DNA Methylation - genetics Early life adversity Epigenesis, Genetic - genetics Epigenetics Female Humans Male Promoter Regions, Genetic - genetics Prospective Studies Serotonin Plasma Membrane Transport Proteins - genetics Stress, Psychological - genetics Stress, Psychological - metabolism Threat Young Adult Youths
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