Gut microbiota metabolite trimethylamine N-oxide promoted NAFLD progression by exacerbating intestinal barrier disruption and intrahepatic cellular imbalance

•Fecal TMAO levels are associated with NAFLD severity.•TMAO promotes the progression of NAFLD models in vitro and in vivo.•TMAO exacerbates intestinal barrier damage and inflammation at various levels.•TMAO promotes endothelial dysfunction and capillarization of LSECs.•TMAO promotes M1 macrophage wh...

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Veröffentlicht in:	International immunopharmacology 2024-12, Vol.142 (Pt B), p.113173, Article 113173
Hauptverfasser:	Nian, Fulin, Chen, Yueying, Xia, Qiaoyun, Zhu, Chen, Wu, Longyun, Lu, Xiaolan
Format:	Artikel
Sprache:	eng
Schlagworte:	Intestinal barrier Liver sinusoidal endothelial cell Macrophage polarization Non-alcoholic fatty liver disease Trimethylamine N-oxide
Online-Zugang:	Volltext
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