Development of purity certified reference materials to establish metrological traceability for the measurement of nitroimidazoles in agricultural products
It is of significant importance to public health that reliable monitoring of nitroimidazoles be conducted, while certified reference materials (CRMs) are essential for accurate and reliable detection. A project has been initiated with the objective of developing nitroimidazole purity CRMs to ensure...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2024-11, Vol.416 (28), p.6437-6449 |
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| creator | Jiang, Bin Liu, QingYi Wang, Min Yang, MengRui Li, FuKai Zhang, LiYuan Zhou, Jian |
| description | It is of significant importance to public health that reliable monitoring of nitroimidazoles be conducted, while certified reference materials (CRMs) are essential for accurate and reliable detection. A project has been initiated with the objective of developing nitroimidazole purity CRMs to ensure that results from nationwide monitoring laboratories for nitroimidazoles in antibiotic residues can be compared and traced. The candidates were successively characterized in terms of their structure by means of infrared (IR) spectroscopy and mass spectrometry (MS). The mass balance (MB) method and the quantitative nuclear magnetic resonance (qNMR) method were utilized to determine the purity of nitroimidazoles with remarkable accuracy. Furthermore, a methodical investigation was conducted on homogeneity, stability, and uncertainty. Six nitroimidazole purity CRMs, including tinidazole (GBW09252), secnidazole (GBW09286), ronidazole (GBW09288), metronidazole (GBW(E)090755), dimetridazole (GBW(E)090819), and ornidazole (GBW(E)090820), were finally manufactured following authorization from China’s State Administration for Market Regulation (SAMR). By using these CRMs, it is possible to improve the traceability, accuracy, and comparability of nitroimidazole measurements in a range of agricultural products, protecting public health.
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| doi_str_mv | 10.1007/s00216-024-05530-3 |
| format | Article |
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A project has been initiated with the objective of developing nitroimidazole purity CRMs to ensure that results from nationwide monitoring laboratories for nitroimidazoles in antibiotic residues can be compared and traced. The candidates were successively characterized in terms of their structure by means of infrared (IR) spectroscopy and mass spectrometry (MS). The mass balance (MB) method and the quantitative nuclear magnetic resonance (qNMR) method were utilized to determine the purity of nitroimidazoles with remarkable accuracy. Furthermore, a methodical investigation was conducted on homogeneity, stability, and uncertainty. Six nitroimidazole purity CRMs, including tinidazole (GBW09252), secnidazole (GBW09286), ronidazole (GBW09288), metronidazole (GBW(E)090755), dimetridazole (GBW(E)090819), and ornidazole (GBW(E)090820), were finally manufactured following authorization from China’s State Administration for Market Regulation (SAMR). By using these CRMs, it is possible to improve the traceability, accuracy, and comparability of nitroimidazole measurements in a range of agricultural products, protecting public health.
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| subjects | Agricultural products Analytical Chemistry Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science China Dimetridazole - analysis Food Science Homogeneity Infrared spectroscopy Laboratory Medicine Magnetic Resonance Spectroscopy - methods Mass balance Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Materials traceability Metronidazole Metronidazole - analogs & derivatives Metronidazole - analysis Monitoring/Environmental Analysis Nitroimidazole Nitroimidazoles - analysis NMR Nuclear magnetic resonance Ornidazole Ornidazole - analysis Public health Purity Reference materials Reference Standards Research Paper Ronidazole - analysis Secnidazole Tinidazole Tinidazole - analysis |
| title | Development of purity certified reference materials to establish metrological traceability for the measurement of nitroimidazoles in agricultural products |
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