Comparative Metabolomics Reveals Changes in the Metabolic Pathways of Ampicillin- and Gentamicin-Resistant Staphylococcus aureus

Antibiotic resistance is a major global challenge requiring new treatments and a better understanding of the bacterial resistance mechanisms. In this study, we compared ampicillin-resistant (R-AMP) and gentamicin-resistant (R-GEN) Staphylococcus aureus strains with a sensitive strain (ATCC6538) usin...

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Veröffentlicht in:	Journal of proteome research 2024-10, Vol.23 (10), p.4480-4494
Hauptverfasser:	Zhang, Ziyi, Pan, Zhiyu, Fan, Lvyuan, Su, Yubin, Fei, Jiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism amino acid metabolism Amino Acids - metabolism ampicillin Ampicillin - pharmacology Anti-Bacterial Agents - pharmacology antibiotic resistance arginine biosynthesis Drug Resistance, Bacterial energy energy metabolism Energy Metabolism - drug effects gentamicin Gentamicins - pharmacology Metabolic Networks and Pathways - drug effects metabolites Metabolome - drug effects metabolomics Metabolomics - methods nitric oxide Nitric Oxide - metabolism proteome pyruvate dehydrogenase (lipoamide) reactive oxygen species Reactive Oxygen Species - metabolism Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - metabolism tricarboxylic acid cycle
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