Engineered Enucleated Mesenchymal Stem Cells Regulating Immune Microenvironment and Promoting Wound Healing

Persistent excessive inflammation caused by neutrophil and macrophage dysfunction in the wound bed leads to refractory response during wound healing. However, previous studies using cytokines or drugs often suffer from short half‐lives and limited targeting, resulting in unsatisfactory therapeutic e...

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Veröffentlicht in:	Advanced materials (Weinheim) 2024-11, Vol.36 (45), p.e2412253-n/a
Hauptverfasser:	Chen, Zhengtai, Zou, Yang, Sun, Hanxiao, He, Yan, Ye, Kai, Li, Yi, Qiu, Lihong, Mai, Yuexue, Chen, Xinghong, Mao, Zhengwei, Yi, Chenggang, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aptamers, Nucleotide - chemistry Beds (process engineering) bioorthogonal chemistry Cell Engineering - methods Cell membranes Cytokines DEK engineered enucleated mesenchymal stem cells Gene expression Humans Interleukin-4 - metabolism macrophage Macrophages Macrophages - cytology Macrophages - metabolism Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mice NETosis Proteins Stem cells Swine Wound healing Wound Healing - drug effects
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