Pure Red Cell Aplasia in a Patient with Thymic Hyperplasia, Hypogammaglobulinemia and Adult T-cell Leukemia/Lymphoma
Acquired pure red cell aplasia (PRCA), caused by thymic hyperplasia, is extremely rare. We herein report a previously healthy 41-year-old man who presented with severe anemia, lymphadenopathy, an upper mediastinal mass, and hypogammaglobulinemia. The patient was eventually diagnosed with PRCA and ad...
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| Veröffentlicht in: | Internal Medicine 2024, pp.4443-24 |
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| creator | Kubota, Yasushi Sano, Haruhiko Takeda, Yuji Yamaguchi, Kyosuke Nakamura, Hideaki Kai, Keita Kidoguchi, Keisuke Kusaba, Kana Yokoo, Masako Ando, Toshihiko Sueoka, Eisaburo Kimura, Shinya |
| description | Acquired pure red cell aplasia (PRCA), caused by thymic hyperplasia, is extremely rare. We herein report a previously healthy 41-year-old man who presented with severe anemia, lymphadenopathy, an upper mediastinal mass, and hypogammaglobulinemia. The patient was eventually diagnosed with PRCA and adult T-cell leukemia/lymphoma (ATLL). The mediastinal mass was pathologically diagnosed as thymic hyperplasia without clear ATLL invasion. Although his anemia improved rapidly after thymectomy, PRCA recurred approximately 500 days later and was accompanied by ATLL exacerbation. The findings in this patient suggest that the Good's syndrome-like symptoms (thymic hyperplasia and hypogammaglobulinemia) in this patient and PRCA may have been paraneoplastic syndromes caused by ATLL. |
| doi_str_mv | 10.2169/internalmedicine.4443-24 |
| format | Article |
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We herein report a previously healthy 41-year-old man who presented with severe anemia, lymphadenopathy, an upper mediastinal mass, and hypogammaglobulinemia. The patient was eventually diagnosed with PRCA and adult T-cell leukemia/lymphoma (ATLL). The mediastinal mass was pathologically diagnosed as thymic hyperplasia without clear ATLL invasion. Although his anemia improved rapidly after thymectomy, PRCA recurred approximately 500 days later and was accompanied by ATLL exacerbation. 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Med.</addtitle><description>Acquired pure red cell aplasia (PRCA), caused by thymic hyperplasia, is extremely rare. We herein report a previously healthy 41-year-old man who presented with severe anemia, lymphadenopathy, an upper mediastinal mass, and hypogammaglobulinemia. The patient was eventually diagnosed with PRCA and adult T-cell leukemia/lymphoma (ATLL). The mediastinal mass was pathologically diagnosed as thymic hyperplasia without clear ATLL invasion. Although his anemia improved rapidly after thymectomy, PRCA recurred approximately 500 days later and was accompanied by ATLL exacerbation. The findings in this patient suggest that the Good's syndrome-like symptoms (thymic hyperplasia and hypogammaglobulinemia) in this patient and PRCA may have been paraneoplastic syndromes caused by ATLL.</description><subject>Good's syndrome</subject><subject>lymphoma</subject><subject>paraneoplastic syndrome</subject><subject>pure red cell aplasia</subject><subject>STAT3</subject><subject>thymectomy</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNplkE9vEzEQxS1ERUPKV0A-cmBbr-3dtY9RBBQpEhVKe7VmvZPExfsH21uUb8-ukuYAl_FY83tvRo8QmrNbnpf6znUJQwe-xcZZ1-GtlFJkXL4hi1xInVVcFG_JgulcZXwq1-R9jM-MCVVp_o5cC8210JVYkPQwBqQ_saFr9J6uBg_RAXUdBfoAyWGX6B-XDnR7OLbO0vvjgOEEfZ4__R7aFva-r0c_HdJOWugaumpGn-g2s7PpBsdf8-Ruc2yHQ9_CDbnagY_44fwuyePXL9v1fbb58e37erXJrFBFysAyhU3FSpCiqnnBayiKmue2qiyXNbcVSC0UorKc5SUruS10I1FpVDtbl2JJPp18h9D_HjEm07o4nwQd9mM0ImdlJbieklgSdUJt6GMMuDNDcC2Eo8mZmTM3_2Zu5swNl5P043nLWE_Di_A15Al4OgHPMcEeLwCE5KzH_52heZm8DHttzpsuAnuAYLATfwFqe6TG</recordid><startdate>20240918</startdate><enddate>20240918</enddate><creator>Kubota, Yasushi</creator><creator>Sano, Haruhiko</creator><creator>Takeda, Yuji</creator><creator>Yamaguchi, Kyosuke</creator><creator>Nakamura, Hideaki</creator><creator>Kai, Keita</creator><creator>Kidoguchi, Keisuke</creator><creator>Kusaba, Kana</creator><creator>Yokoo, Masako</creator><creator>Ando, Toshihiko</creator><creator>Sueoka, Eisaburo</creator><creator>Kimura, Shinya</creator><general>The Japanese Society of Internal Medicine</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240918</creationdate><title>Pure Red Cell Aplasia in a Patient with Thymic Hyperplasia, Hypogammaglobulinemia and Adult T-cell Leukemia/Lymphoma</title><author>Kubota, Yasushi ; Sano, Haruhiko ; Takeda, Yuji ; Yamaguchi, Kyosuke ; Nakamura, Hideaki ; Kai, Keita ; Kidoguchi, Keisuke ; Kusaba, Kana ; Yokoo, Masako ; Ando, Toshihiko ; Sueoka, Eisaburo ; Kimura, Shinya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-ac08ed706a437b252ba55b21c77c24b2c7a4938ee8c2016062c59d4e89e8fcb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Good's syndrome</topic><topic>lymphoma</topic><topic>paraneoplastic syndrome</topic><topic>pure red cell aplasia</topic><topic>STAT3</topic><topic>thymectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubota, Yasushi</creatorcontrib><creatorcontrib>Sano, Haruhiko</creatorcontrib><creatorcontrib>Takeda, Yuji</creatorcontrib><creatorcontrib>Yamaguchi, Kyosuke</creatorcontrib><creatorcontrib>Nakamura, Hideaki</creatorcontrib><creatorcontrib>Kai, Keita</creatorcontrib><creatorcontrib>Kidoguchi, Keisuke</creatorcontrib><creatorcontrib>Kusaba, Kana</creatorcontrib><creatorcontrib>Yokoo, Masako</creatorcontrib><creatorcontrib>Ando, Toshihiko</creatorcontrib><creatorcontrib>Sueoka, Eisaburo</creatorcontrib><creatorcontrib>Kimura, Shinya</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubota, Yasushi</au><au>Sano, Haruhiko</au><au>Takeda, Yuji</au><au>Yamaguchi, Kyosuke</au><au>Nakamura, Hideaki</au><au>Kai, Keita</au><au>Kidoguchi, Keisuke</au><au>Kusaba, Kana</au><au>Yokoo, Masako</au><au>Ando, Toshihiko</au><au>Sueoka, Eisaburo</au><au>Kimura, Shinya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pure Red Cell Aplasia in a Patient with Thymic Hyperplasia, Hypogammaglobulinemia and Adult T-cell Leukemia/Lymphoma</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2024-09-18</date><risdate>2024</risdate><spage>4443-24</spage><pages>4443-24-</pages><artnum>4443-24</artnum><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>Acquired pure red cell aplasia (PRCA), caused by thymic hyperplasia, is extremely rare. We herein report a previously healthy 41-year-old man who presented with severe anemia, lymphadenopathy, an upper mediastinal mass, and hypogammaglobulinemia. The patient was eventually diagnosed with PRCA and adult T-cell leukemia/lymphoma (ATLL). The mediastinal mass was pathologically diagnosed as thymic hyperplasia without clear ATLL invasion. Although his anemia improved rapidly after thymectomy, PRCA recurred approximately 500 days later and was accompanied by ATLL exacerbation. The findings in this patient suggest that the Good's syndrome-like symptoms (thymic hyperplasia and hypogammaglobulinemia) in this patient and PRCA may have been paraneoplastic syndromes caused by ATLL.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>39293973</pmid><doi>10.2169/internalmedicine.4443-24</doi><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; PubMed Central Open Access; PubMed Central |
| subjects | Good's syndrome lymphoma paraneoplastic syndrome pure red cell aplasia STAT3 thymectomy |
| title | Pure Red Cell Aplasia in a Patient with Thymic Hyperplasia, Hypogammaglobulinemia and Adult T-cell Leukemia/Lymphoma |
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