Metabolic regulation of the tumour and its microenvironment: The role of Epstein–Barr virus
The Epstein–Barr virus (EBV), the first identified human tumour virus, infects over 95% of the individuals globally and has the potential to induce different types of cancers. It is increasingly recognised that EBV infection not only alters cellular metabolism, contributing to neoplastic transformat...
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| Veröffentlicht in: | International journal of cancer 2025-02, Vol.156 (3), p.488-498 |
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| creator | Lee, Shen‐Han Khoo, Alan Soo‐Beng Griffiths, John R. Mat Lazim, Norhafiza |
| description | The Epstein–Barr virus (EBV), the first identified human tumour virus, infects over 95% of the individuals globally and has the potential to induce different types of cancers. It is increasingly recognised that EBV infection not only alters cellular metabolism, contributing to neoplastic transformation, but also utilises several non‐cell autonomous mechanisms to shape the metabolic milieu in the tumour microenvironment (TME) and its constituent stromal and immune cells. In this review, we explore how EBV modulates metabolism to shape the interactions between cancer cells, stromal cells, and immune cells within a hypoxic and acidic TME. We highlight how metabolites resulting from EBV infection act as paracrine factors to regulate the TME, and how targeting them can disrupt barriers to immunotherapy.
Epstein‐Barr virus (EBV) influences metabolism of the tumour and its microenvironment through various signalling pathways and paracrine factors, which can be targeted to disrupt barriers to immunotherapy. |
| doi_str_mv | 10.1002/ijc.35192 |
| format | Article |
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Epstein‐Barr virus (EBV) influences metabolism of the tumour and its microenvironment through various signalling pathways and paracrine factors, which can be targeted to disrupt barriers to immunotherapy.</description><subject>Animals</subject><subject>EBV‐associated malignancies</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - metabolism</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Herpesvirus 4, Human - metabolism</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Immunotherapy</subject><subject>nasopharyngeal cancer</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - virology</subject><subject>Paracrine signalling</subject><subject>Stromal cells</subject><subject>Stromal Cells - metabolism</subject><subject>Stromal Cells - pathology</subject><subject>Stromal Cells - virology</subject><subject>Tumor Microenvironment</subject><subject>Tumors</subject><subject>tumour metabolism</subject><subject>tumour microenvironment</subject><issn>0020-7136</issn><issn>1097-0215</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10LtOwzAUBmALgWi5DLwAssQCQ-D4ltRsUJWbQCxlRFEuJ-AqiYudgLrxDrwhT4KhwIDEdAZ__nXOT8gOg0MGwI_MrDgUimm-QoYMdBIBZ2qVDMMbRAkT8YBseD8DYEyBXCcDoblm8UgMyf0Ndllua1NQhw99nXXGttRWtHtE2vWN7R3N2pKaztPGFM5i-2ycbRtsu2M6DcjZGj8_TOa-Q9O-v76dZs7RoHq_RdaqrPa4_T03yd3ZZDq-iK5vzy_HJ9dRwaXgUZVIKUuRFKXKNXJUkItS5yWCiuNYSyw56DwZaSyAq6LiICHPyhgYV1pWudgk-8vcubNPPfoubYwvsK6zFm3vU8EgljFXigW694fOwo1t2C4oyQSMhOJBHSxVuNh7h1U6d6bJ3CJlkH52nobO06_Og939TuzzBstf-VNyAEdL8GJqXPyflF5ejZeRH8kQiyY</recordid><startdate>20250201</startdate><enddate>20250201</enddate><creator>Lee, Shen‐Han</creator><creator>Khoo, Alan Soo‐Beng</creator><creator>Griffiths, John R.</creator><creator>Mat Lazim, Norhafiza</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2367-1814</orcidid><orcidid>https://orcid.org/0000-0002-8268-5271</orcidid><orcidid>https://orcid.org/0000-0002-6147-2963</orcidid><orcidid>https://orcid.org/0000-0001-7369-6836</orcidid></search><sort><creationdate>20250201</creationdate><title>Metabolic regulation of the tumour and its microenvironment: The role of Epstein–Barr virus</title><author>Lee, Shen‐Han ; Khoo, Alan Soo‐Beng ; Griffiths, John R. ; Mat Lazim, Norhafiza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2432-f7444d37cd5b9e2e50b3d9bde0566694ed209b789ec025cf2040bad6012594fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animals</topic><topic>EBV‐associated malignancies</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - metabolism</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Herpesvirus 4, Human - metabolism</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Immunotherapy</topic><topic>nasopharyngeal cancer</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - virology</topic><topic>Paracrine signalling</topic><topic>Stromal cells</topic><topic>Stromal Cells - metabolism</topic><topic>Stromal Cells - pathology</topic><topic>Stromal Cells - virology</topic><topic>Tumor Microenvironment</topic><topic>Tumors</topic><topic>tumour metabolism</topic><topic>tumour microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Shen‐Han</creatorcontrib><creatorcontrib>Khoo, Alan Soo‐Beng</creatorcontrib><creatorcontrib>Griffiths, John R.</creatorcontrib><creatorcontrib>Mat Lazim, Norhafiza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Shen‐Han</au><au>Khoo, Alan Soo‐Beng</au><au>Griffiths, John R.</au><au>Mat Lazim, Norhafiza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic regulation of the tumour and its microenvironment: The role of Epstein–Barr virus</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2025-02-01</date><risdate>2025</risdate><volume>156</volume><issue>3</issue><spage>488</spage><epage>498</epage><pages>488-498</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><abstract>The Epstein–Barr virus (EBV), the first identified human tumour virus, infects over 95% of the individuals globally and has the potential to induce different types of cancers. It is increasingly recognised that EBV infection not only alters cellular metabolism, contributing to neoplastic transformation, but also utilises several non‐cell autonomous mechanisms to shape the metabolic milieu in the tumour microenvironment (TME) and its constituent stromal and immune cells. In this review, we explore how EBV modulates metabolism to shape the interactions between cancer cells, stromal cells, and immune cells within a hypoxic and acidic TME. We highlight how metabolites resulting from EBV infection act as paracrine factors to regulate the TME, and how targeting them can disrupt barriers to immunotherapy.
Epstein‐Barr virus (EBV) influences metabolism of the tumour and its microenvironment through various signalling pathways and paracrine factors, which can be targeted to disrupt barriers to immunotherapy.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>39291683</pmid><doi>10.1002/ijc.35192</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2367-1814</orcidid><orcidid>https://orcid.org/0000-0002-8268-5271</orcidid><orcidid>https://orcid.org/0000-0002-6147-2963</orcidid><orcidid>https://orcid.org/0000-0001-7369-6836</orcidid></addata></record> |
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| subjects | Animals EBV‐associated malignancies Epstein-Barr virus Epstein-Barr Virus Infections - metabolism Epstein-Barr Virus Infections - virology Herpesvirus 4, Human - metabolism Humans Hypoxia Immunotherapy nasopharyngeal cancer Neoplasms - metabolism Neoplasms - pathology Neoplasms - virology Paracrine signalling Stromal cells Stromal Cells - metabolism Stromal Cells - pathology Stromal Cells - virology Tumor Microenvironment Tumors tumour metabolism tumour microenvironment |
| title | Metabolic regulation of the tumour and its microenvironment: The role of Epstein–Barr virus |
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