Dietary eugenol ameliorates long-term high-fat diet-induced skeletal muscle atrophy: mechanistic insights from integrated multi-omics

Eugenol (EU), the major constituent of clove oil, possesses a range of bioactivities. Here, the therapeutic potential of oral EU for mitigating skeletal muscle wasting was investigated in a long-term high-fat diet (HFD)-induced obese mice model. Male C57BL/6J mice, aged six weeks, were assigned to e...

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Veröffentlicht in:	Food & function 2024-09, Vol.15 (19), p.10136-10150
Hauptverfasser:	Li, Mengjie, Guo, Jingya, Qin, Yige, Lao, Yujie, Kang, Seong-Gook, Huang, Kunlun, Tong, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy Diet Diet, High-Fat - adverse effects Dietary Supplements Dysbacteriosis Eugenol Eugenol - pharmacology Gastrocnemius muscle Gastrointestinal Microbiome - drug effects Gene sequencing Grip strength High fat diet Intestinal microflora Male Metabolomics Mice Mice, Inbred C57BL Microbiomes Multiomics Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscles Muscular Atrophy - drug therapy Muscular Atrophy - metabolism Musculoskeletal system Nucleotides rRNA 16S Sequence analysis Signal transduction Skeletal muscle Transcriptome Transcriptomes Transcriptomics
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