Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice
Objective Pro-resolving molecules, including the peptide Angiotensin-(1–7) [Ang-(1–7)], have potential adjunctive therapy for infections. Here we evaluate the actions of Ang-(1–7) in betacoronavirus infection in mice. Methods C57BL/6J mice were infected intranasally with the murine betacoronavirus M...
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| Veröffentlicht in: | Inflammation research 2024-11, Vol.73 (11), p.2009-2022 |
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| creator | Lima, Erick Bryan de Sousa Carvalho, Antônio Felipe S. Zaidan, Isabella Monteiro, Adelson Héric A. Cardoso, Camila Lara, Edvaldo S. Carneiro, Fernanda S. Oliveira, Leonardo C. Resende, Filipe Santos, Felipe Rocha da Silva Souza-Costa, Luiz Pedro Chaves, Ian de Meira Queiroz-Junior, Celso M. Russo, Remo C. Santos, Robson A. S. Tavares, Luciana P. Teixeira, Mauro M. Costa, Vivian V. Sousa, Lirlândia P. |
| description | Objective
Pro-resolving molecules, including the peptide Angiotensin-(1–7) [Ang-(1–7)], have potential adjunctive therapy for infections. Here we evaluate the actions of Ang-(1–7) in betacoronavirus infection in mice.
Methods
C57BL/6J mice were infected intranasally with the murine betacoronavirus MHV-3 and K18-hACE2 mice were infected with SARS-CoV-2. Mice were treated with Ang-(1–7) (30 µg/mouse, i.p.) at 24-, 36-, and 48-hours post-infection (hpi) or at 24, 36, 48, 72, and 96 h. For lethality evaluation, one additional dose of Ang-(1–7) was given at 120 hpi. At 3- and 5-days post- infection (dpi) blood cells, inflammatory mediators, viral loads, and lung histopathology were evaluated.
Results
Ang-(1–7) rescued lymphopenia in MHV-infected mice, and decreased airways leukocyte infiltration and lung damage at 3- and 5-dpi. The levels of pro-inflammatory cytokines and virus titers in lung and plasma were decreased by Ang-(1–7) during MHV infection. Ang-(1–7) improved lung function and increased survival rates in MHV-infected mice. Notably, Ang-(1–7) treatment during SARS-CoV-2 infection restored blood lymphocytes to baseline, decreased weight loss, virus titters and levels of inflammatory cytokines, resulting in improvement of pulmonary damage, clinical scores and lethality rates.
Conclusion
Ang-(1–7) protected mice from lung damage and death during betacoronavirus infections by modulating inflammation, hematological parameters and enhancing viral clearance.
Graphical Abstract |
| doi_str_mv | 10.1007/s00011-024-01948-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3106461335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3124932158</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-1325716687d7ebd11fc3db781c9f8dc6c04b77e24c925db2662f0e4b8a189b723</originalsourceid><addsrcrecordid>eNp9kctq3TAQhkVJaa4v0EURZJMs1Eoj25KXIfQGgW5a6E7oMj4o2HIi2YHs8g59wz5JlHPSFrLoagbm-_8Z5ifkreDvBefqQ-GcC8E4NIyLvtFMvyIHogHOeq5_7tWeg2RSS75PDku5rrgGDW_IvuyhB1D8gAwXaRPnBVOJiZ2J3w-_1DkN6DPagoXGNIx2muwS50RtCnRc04YGO9kNUm_XgoG6e-pwsX7Oc7J3Ma9bGfqtJiY6RY_H5PVgx4Inz_WI_Pj08fvlF3b17fPXy4sr5qHtFiYktEp0nVZBoQtCDF4Gp7Tw_aCD7zxvnFIIje-hDQ66DgaOjdNW6N4pkEfkbOd7k-fbFctiplg8jqNNOK_FSMG7phNSthU9fYFez2tO9bpKQdNLEK2uFOwon-dSMg7mJsfJ5nsjuHlKwexSMDUFs03BPInePVuvbsLwV_Ln7RWQO6DUUdpg_rf7P7aPI-qSoA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3124932158</pqid></control><display><type>article</type><title>Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Lima, Erick Bryan de Sousa ; Carvalho, Antônio Felipe S. ; Zaidan, Isabella ; Monteiro, Adelson Héric A. ; Cardoso, Camila ; Lara, Edvaldo S. ; Carneiro, Fernanda S. ; Oliveira, Leonardo C. ; Resende, Filipe ; Santos, Felipe Rocha da Silva ; Souza-Costa, Luiz Pedro ; Chaves, Ian de Meira ; Queiroz-Junior, Celso M. ; Russo, Remo C. ; Santos, Robson A. S. ; Tavares, Luciana P. ; Teixeira, Mauro M. ; Costa, Vivian V. ; Sousa, Lirlândia P.</creator><creatorcontrib>Lima, Erick Bryan de Sousa ; Carvalho, Antônio Felipe S. ; Zaidan, Isabella ; Monteiro, Adelson Héric A. ; Cardoso, Camila ; Lara, Edvaldo S. ; Carneiro, Fernanda S. ; Oliveira, Leonardo C. ; Resende, Filipe ; Santos, Felipe Rocha da Silva ; Souza-Costa, Luiz Pedro ; Chaves, Ian de Meira ; Queiroz-Junior, Celso M. ; Russo, Remo C. ; Santos, Robson A. S. ; Tavares, Luciana P. ; Teixeira, Mauro M. ; Costa, Vivian V. ; Sousa, Lirlândia P.</creatorcontrib><description>Objective
Pro-resolving molecules, including the peptide Angiotensin-(1–7) [Ang-(1–7)], have potential adjunctive therapy for infections. Here we evaluate the actions of Ang-(1–7) in betacoronavirus infection in mice.
Methods
C57BL/6J mice were infected intranasally with the murine betacoronavirus MHV-3 and K18-hACE2 mice were infected with SARS-CoV-2. Mice were treated with Ang-(1–7) (30 µg/mouse, i.p.) at 24-, 36-, and 48-hours post-infection (hpi) or at 24, 36, 48, 72, and 96 h. For lethality evaluation, one additional dose of Ang-(1–7) was given at 120 hpi. At 3- and 5-days post- infection (dpi) blood cells, inflammatory mediators, viral loads, and lung histopathology were evaluated.
Results
Ang-(1–7) rescued lymphopenia in MHV-infected mice, and decreased airways leukocyte infiltration and lung damage at 3- and 5-dpi. The levels of pro-inflammatory cytokines and virus titers in lung and plasma were decreased by Ang-(1–7) during MHV infection. Ang-(1–7) improved lung function and increased survival rates in MHV-infected mice. Notably, Ang-(1–7) treatment during SARS-CoV-2 infection restored blood lymphocytes to baseline, decreased weight loss, virus titters and levels of inflammatory cytokines, resulting in improvement of pulmonary damage, clinical scores and lethality rates.
Conclusion
Ang-(1–7) protected mice from lung damage and death during betacoronavirus infections by modulating inflammation, hematological parameters and enhancing viral clearance.
Graphical Abstract</description><identifier>ISSN: 1023-3830</identifier><identifier>ISSN: 1420-908X</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-024-01948-8</identifier><identifier>PMID: 39292270</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Angiotensin ; Angiotensin I - pharmacology ; Angiotensin I - therapeutic use ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood cells ; Coronavirus Infections - drug therapy ; Coronavirus Infections - pathology ; COVID-19 ; Cytokines ; Cytokines - blood ; Damage ; Dermatology ; Female ; Histopathology ; Immunology ; Infections ; Inflammation ; Inflammation - drug therapy ; Lethality ; Lung - drug effects ; Lung - pathology ; Lung - virology ; Lungs ; Lymphocytes ; Lymphopenia ; Lymphopenia - drug therapy ; Male ; Mice ; Mice, Inbred C57BL ; Murine hepatitis virus - drug effects ; Neurology ; Original Research Paper ; Peptide Fragments - pharmacology ; Peptide Fragments - therapeutic use ; Pharmacology/Toxicology ; Respiratory function ; Rheumatology ; SARS-CoV-2 - drug effects ; Severe acute respiratory syndrome coronavirus 2 ; Survival ; Viral diseases ; Viral Load - drug effects ; Viruses ; Weight loss</subject><ispartof>Inflammation research, 2024-11, Vol.73 (11), p.2009-2022</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-1325716687d7ebd11fc3db781c9f8dc6c04b77e24c925db2662f0e4b8a189b723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00011-024-01948-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00011-024-01948-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39292270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Erick Bryan de Sousa</creatorcontrib><creatorcontrib>Carvalho, Antônio Felipe S.</creatorcontrib><creatorcontrib>Zaidan, Isabella</creatorcontrib><creatorcontrib>Monteiro, Adelson Héric A.</creatorcontrib><creatorcontrib>Cardoso, Camila</creatorcontrib><creatorcontrib>Lara, Edvaldo S.</creatorcontrib><creatorcontrib>Carneiro, Fernanda S.</creatorcontrib><creatorcontrib>Oliveira, Leonardo C.</creatorcontrib><creatorcontrib>Resende, Filipe</creatorcontrib><creatorcontrib>Santos, Felipe Rocha da Silva</creatorcontrib><creatorcontrib>Souza-Costa, Luiz Pedro</creatorcontrib><creatorcontrib>Chaves, Ian de Meira</creatorcontrib><creatorcontrib>Queiroz-Junior, Celso M.</creatorcontrib><creatorcontrib>Russo, Remo C.</creatorcontrib><creatorcontrib>Santos, Robson A. S.</creatorcontrib><creatorcontrib>Tavares, Luciana P.</creatorcontrib><creatorcontrib>Teixeira, Mauro M.</creatorcontrib><creatorcontrib>Costa, Vivian V.</creatorcontrib><creatorcontrib>Sousa, Lirlândia P.</creatorcontrib><title>Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice</title><title>Inflammation research</title><addtitle>Inflamm. Res</addtitle><addtitle>Inflamm Res</addtitle><description>Objective
Pro-resolving molecules, including the peptide Angiotensin-(1–7) [Ang-(1–7)], have potential adjunctive therapy for infections. Here we evaluate the actions of Ang-(1–7) in betacoronavirus infection in mice.
Methods
C57BL/6J mice were infected intranasally with the murine betacoronavirus MHV-3 and K18-hACE2 mice were infected with SARS-CoV-2. Mice were treated with Ang-(1–7) (30 µg/mouse, i.p.) at 24-, 36-, and 48-hours post-infection (hpi) or at 24, 36, 48, 72, and 96 h. For lethality evaluation, one additional dose of Ang-(1–7) was given at 120 hpi. At 3- and 5-days post- infection (dpi) blood cells, inflammatory mediators, viral loads, and lung histopathology were evaluated.
Results
Ang-(1–7) rescued lymphopenia in MHV-infected mice, and decreased airways leukocyte infiltration and lung damage at 3- and 5-dpi. The levels of pro-inflammatory cytokines and virus titers in lung and plasma were decreased by Ang-(1–7) during MHV infection. Ang-(1–7) improved lung function and increased survival rates in MHV-infected mice. Notably, Ang-(1–7) treatment during SARS-CoV-2 infection restored blood lymphocytes to baseline, decreased weight loss, virus titters and levels of inflammatory cytokines, resulting in improvement of pulmonary damage, clinical scores and lethality rates.
Conclusion
Ang-(1–7) protected mice from lung damage and death during betacoronavirus infections by modulating inflammation, hematological parameters and enhancing viral clearance.
Graphical Abstract</description><subject>Allergology</subject><subject>Angiotensin</subject><subject>Angiotensin I - pharmacology</subject><subject>Angiotensin I - therapeutic use</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood cells</subject><subject>Coronavirus Infections - drug therapy</subject><subject>Coronavirus Infections - pathology</subject><subject>COVID-19</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Damage</subject><subject>Dermatology</subject><subject>Female</subject><subject>Histopathology</subject><subject>Immunology</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Lethality</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Lung - virology</subject><subject>Lungs</subject><subject>Lymphocytes</subject><subject>Lymphopenia</subject><subject>Lymphopenia - drug therapy</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Murine hepatitis virus - drug effects</subject><subject>Neurology</subject><subject>Original Research Paper</subject><subject>Peptide Fragments - pharmacology</subject><subject>Peptide Fragments - therapeutic use</subject><subject>Pharmacology/Toxicology</subject><subject>Respiratory function</subject><subject>Rheumatology</subject><subject>SARS-CoV-2 - drug effects</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Survival</subject><subject>Viral diseases</subject><subject>Viral Load - drug effects</subject><subject>Viruses</subject><subject>Weight loss</subject><issn>1023-3830</issn><issn>1420-908X</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctq3TAQhkVJaa4v0EURZJMs1Eoj25KXIfQGgW5a6E7oMj4o2HIi2YHs8g59wz5JlHPSFrLoagbm-_8Z5ifkreDvBefqQ-GcC8E4NIyLvtFMvyIHogHOeq5_7tWeg2RSS75PDku5rrgGDW_IvuyhB1D8gAwXaRPnBVOJiZ2J3w-_1DkN6DPagoXGNIx2muwS50RtCnRc04YGO9kNUm_XgoG6e-pwsX7Oc7J3Ma9bGfqtJiY6RY_H5PVgx4Inz_WI_Pj08fvlF3b17fPXy4sr5qHtFiYktEp0nVZBoQtCDF4Gp7Tw_aCD7zxvnFIIje-hDQ66DgaOjdNW6N4pkEfkbOd7k-fbFctiplg8jqNNOK_FSMG7phNSthU9fYFez2tO9bpKQdNLEK2uFOwon-dSMg7mJsfJ5nsjuHlKwexSMDUFs03BPInePVuvbsLwV_Ln7RWQO6DUUdpg_rf7P7aPI-qSoA</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Lima, Erick Bryan de Sousa</creator><creator>Carvalho, Antônio Felipe S.</creator><creator>Zaidan, Isabella</creator><creator>Monteiro, Adelson Héric A.</creator><creator>Cardoso, Camila</creator><creator>Lara, Edvaldo S.</creator><creator>Carneiro, Fernanda S.</creator><creator>Oliveira, Leonardo C.</creator><creator>Resende, Filipe</creator><creator>Santos, Felipe Rocha da Silva</creator><creator>Souza-Costa, Luiz Pedro</creator><creator>Chaves, Ian de Meira</creator><creator>Queiroz-Junior, Celso M.</creator><creator>Russo, Remo C.</creator><creator>Santos, Robson A. S.</creator><creator>Tavares, Luciana P.</creator><creator>Teixeira, Mauro M.</creator><creator>Costa, Vivian V.</creator><creator>Sousa, Lirlândia P.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20241101</creationdate><title>Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice</title><author>Lima, Erick Bryan de Sousa ; Carvalho, Antônio Felipe S. ; Zaidan, Isabella ; Monteiro, Adelson Héric A. ; Cardoso, Camila ; Lara, Edvaldo S. ; Carneiro, Fernanda S. ; Oliveira, Leonardo C. ; Resende, Filipe ; Santos, Felipe Rocha da Silva ; Souza-Costa, Luiz Pedro ; Chaves, Ian de Meira ; Queiroz-Junior, Celso M. ; Russo, Remo C. ; Santos, Robson A. S. ; Tavares, Luciana P. ; Teixeira, Mauro M. ; Costa, Vivian V. ; Sousa, Lirlândia P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-1325716687d7ebd11fc3db781c9f8dc6c04b77e24c925db2662f0e4b8a189b723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Allergology</topic><topic>Angiotensin</topic><topic>Angiotensin I - pharmacology</topic><topic>Angiotensin I - therapeutic use</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood cells</topic><topic>Coronavirus Infections - drug therapy</topic><topic>Coronavirus Infections - pathology</topic><topic>COVID-19</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Damage</topic><topic>Dermatology</topic><topic>Female</topic><topic>Histopathology</topic><topic>Immunology</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Lethality</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Lung - virology</topic><topic>Lungs</topic><topic>Lymphocytes</topic><topic>Lymphopenia</topic><topic>Lymphopenia - drug therapy</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Murine hepatitis virus - drug effects</topic><topic>Neurology</topic><topic>Original Research Paper</topic><topic>Peptide Fragments - pharmacology</topic><topic>Peptide Fragments - therapeutic use</topic><topic>Pharmacology/Toxicology</topic><topic>Respiratory function</topic><topic>Rheumatology</topic><topic>SARS-CoV-2 - drug effects</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Survival</topic><topic>Viral diseases</topic><topic>Viral Load - drug effects</topic><topic>Viruses</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Erick Bryan de Sousa</creatorcontrib><creatorcontrib>Carvalho, Antônio Felipe S.</creatorcontrib><creatorcontrib>Zaidan, Isabella</creatorcontrib><creatorcontrib>Monteiro, Adelson Héric A.</creatorcontrib><creatorcontrib>Cardoso, Camila</creatorcontrib><creatorcontrib>Lara, Edvaldo S.</creatorcontrib><creatorcontrib>Carneiro, Fernanda S.</creatorcontrib><creatorcontrib>Oliveira, Leonardo C.</creatorcontrib><creatorcontrib>Resende, Filipe</creatorcontrib><creatorcontrib>Santos, Felipe Rocha da Silva</creatorcontrib><creatorcontrib>Souza-Costa, Luiz Pedro</creatorcontrib><creatorcontrib>Chaves, Ian de Meira</creatorcontrib><creatorcontrib>Queiroz-Junior, Celso M.</creatorcontrib><creatorcontrib>Russo, Remo C.</creatorcontrib><creatorcontrib>Santos, Robson A. S.</creatorcontrib><creatorcontrib>Tavares, Luciana P.</creatorcontrib><creatorcontrib>Teixeira, Mauro M.</creatorcontrib><creatorcontrib>Costa, Vivian V.</creatorcontrib><creatorcontrib>Sousa, Lirlândia P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Erick Bryan de Sousa</au><au>Carvalho, Antônio Felipe S.</au><au>Zaidan, Isabella</au><au>Monteiro, Adelson Héric A.</au><au>Cardoso, Camila</au><au>Lara, Edvaldo S.</au><au>Carneiro, Fernanda S.</au><au>Oliveira, Leonardo C.</au><au>Resende, Filipe</au><au>Santos, Felipe Rocha da Silva</au><au>Souza-Costa, Luiz Pedro</au><au>Chaves, Ian de Meira</au><au>Queiroz-Junior, Celso M.</au><au>Russo, Remo C.</au><au>Santos, Robson A. S.</au><au>Tavares, Luciana P.</au><au>Teixeira, Mauro M.</au><au>Costa, Vivian V.</au><au>Sousa, Lirlândia P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice</atitle><jtitle>Inflammation research</jtitle><stitle>Inflamm. Res</stitle><addtitle>Inflamm Res</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>73</volume><issue>11</issue><spage>2009</spage><epage>2022</epage><pages>2009-2022</pages><issn>1023-3830</issn><issn>1420-908X</issn><eissn>1420-908X</eissn><abstract>Objective
Pro-resolving molecules, including the peptide Angiotensin-(1–7) [Ang-(1–7)], have potential adjunctive therapy for infections. Here we evaluate the actions of Ang-(1–7) in betacoronavirus infection in mice.
Methods
C57BL/6J mice were infected intranasally with the murine betacoronavirus MHV-3 and K18-hACE2 mice were infected with SARS-CoV-2. Mice were treated with Ang-(1–7) (30 µg/mouse, i.p.) at 24-, 36-, and 48-hours post-infection (hpi) or at 24, 36, 48, 72, and 96 h. For lethality evaluation, one additional dose of Ang-(1–7) was given at 120 hpi. At 3- and 5-days post- infection (dpi) blood cells, inflammatory mediators, viral loads, and lung histopathology were evaluated.
Results
Ang-(1–7) rescued lymphopenia in MHV-infected mice, and decreased airways leukocyte infiltration and lung damage at 3- and 5-dpi. The levels of pro-inflammatory cytokines and virus titers in lung and plasma were decreased by Ang-(1–7) during MHV infection. Ang-(1–7) improved lung function and increased survival rates in MHV-infected mice. Notably, Ang-(1–7) treatment during SARS-CoV-2 infection restored blood lymphocytes to baseline, decreased weight loss, virus titters and levels of inflammatory cytokines, resulting in improvement of pulmonary damage, clinical scores and lethality rates.
Conclusion
Ang-(1–7) protected mice from lung damage and death during betacoronavirus infections by modulating inflammation, hematological parameters and enhancing viral clearance.
Graphical Abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>39292270</pmid><doi>10.1007/s00011-024-01948-8</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1023-3830 |
| ispartof | Inflammation research, 2024-11, Vol.73 (11), p.2009-2022 |
| issn | 1023-3830 1420-908X 1420-908X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3106461335 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Allergology Angiotensin Angiotensin I - pharmacology Angiotensin I - therapeutic use Animals Biomedical and Life Sciences Biomedicine Blood cells Coronavirus Infections - drug therapy Coronavirus Infections - pathology COVID-19 Cytokines Cytokines - blood Damage Dermatology Female Histopathology Immunology Infections Inflammation Inflammation - drug therapy Lethality Lung - drug effects Lung - pathology Lung - virology Lungs Lymphocytes Lymphopenia Lymphopenia - drug therapy Male Mice Mice, Inbred C57BL Murine hepatitis virus - drug effects Neurology Original Research Paper Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Pharmacology/Toxicology Respiratory function Rheumatology SARS-CoV-2 - drug effects Severe acute respiratory syndrome coronavirus 2 Survival Viral diseases Viral Load - drug effects Viruses Weight loss |
| title | Angiotensin-(1–7) decreases inflammation and lung damage caused by betacoronavirus infection in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T11%3A46%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angiotensin-(1%E2%80%937)%20decreases%20inflammation%20and%20lung%20damage%20caused%20by%20betacoronavirus%20infection%20in%20mice&rft.jtitle=Inflammation%20research&rft.au=Lima,%20Erick%20Bryan%20de%20Sousa&rft.date=2024-11-01&rft.volume=73&rft.issue=11&rft.spage=2009&rft.epage=2022&rft.pages=2009-2022&rft.issn=1023-3830&rft.eissn=1420-908X&rft_id=info:doi/10.1007/s00011-024-01948-8&rft_dat=%3Cproquest_cross%3E3124932158%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3124932158&rft_id=info:pmid/39292270&rfr_iscdi=true |