Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD + -SIRT2 axis

Palmitic acid is the most abundant saturated fatty acid in circulation and causes hepatocyte toxicity and inflammation. As saturated fatty acid can also disrupt the circadian rhythm, the present work evaluated the connection between clock genes and NAD+ dependent Sirtuins in protecting hepatocytes f...

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Veröffentlicht in:	Journal of physiology and biochemistry 2024-11, Vol.80 (4), p.845-864
Hauptverfasser:	Aggarwal, Savera, Rastogi, Archana, Maiwall, Rakhi, Sevak, Jayesh K, Yadav, Vipin, Maras, Jaswinder, Thomas, Sherin Sarah, Kale, Pratibha R, Pamecha, Viniyendra, Perumal, Nagarajan, Trehanpati, Nirupama, Ramakrishna, Gayatri
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism BMAL1 protein Chromatin Circadian Rhythm Circadian rhythms Cirrhosis Damage assessment Ectopic expression Fatty acids Fibrosis Hep G2 Cells Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Hepatoma Humans Inflammation Inflammation - metabolism Interleukins Lipids Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Male NAD NAD - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Nicotinamide Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Palmitic acid Palmitic Acid - pharmacology Pyridinium Compounds - pharmacology Signal Transduction - drug effects Sirtuin 2 - genetics Sirtuin 2 - metabolism Sirtuins Steatosis Toxicity Transcription activation Tubulin
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