Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice

•Ginkgolide A delays chondrocyte apoptosis and extracellular matrix degradation.•Ginkgolide A modulates FoxO1-mediated endoplasmic reticulum stress.•Ginkgolide A has the potential to serve as a therapeutic agent for osteoarthritis. This study aimed to investigate the effects of Ginkgolide A (GA) on...

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Veröffentlicht in:	International immunopharmacology 2024-12, Vol.142 (Pt B), p.113116, Article 113116
Hauptverfasser:	Yu, Heng, Liang, Jinghao, Bao, Yingying, Chen, Kaiye, Jin, Yangcan, Li, Xiang, Chen, Hao, Gou, Yong, Lu, Keyu, Lin, Zhongke
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Endoplasmic reticulum stress FoxO1 Ginkgolide A Network pharmacology Osteoarthritis
Online-Zugang:	Volltext
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