Genetic Risk Factors in Isolated Dystonia Escape Genome‐Wide Association Studies

Background Despite considerable heritability, previous smaller genome‐wide association studies (GWASs) have not identified any robust genetic risk factors for isolated dystonia. Objective The objective of this study was to perform a large‐scale GWAS in a well‐characterized, multicenter sample of >...

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Veröffentlicht in:	Movement disorders 2024-11, Vol.39 (11), p.2110-2116
Hauptverfasser:	Laabs, Björn‐Hergen, Lohmann, Katja, Vollstedt, Eva‐Juliane, Reinberger, Tobias, Nuxoll, Lisa‐Marie, Kilic‐Berkmen, Gamze, Perlmutter, Joel S., Loens, Sebastian, Cruchaga, Carlos, Franke, Andre, Dobricic, Valerija, Hinrichs, Frauke, Grözinger, Anne, Altenmüller, Eckart, Bellows, Steven, Boesch, Sylvia, Bressman, Susan B., Duque, Kevin R., Espay, Alberto J., Ferbert, Andreas, Feuerstein, Jeanne S., Frank, Samuel, Gasser, Thomas, Haslinger, Bernhard, Jech, Robert, Kaiser, Frank, Kamm, Christoph, Kollewe, Katja, Kühn, Andrea A., LeDoux, Mark S., Lohmann, Ebba, Mahajan, Abhimanyu, Münchau, Alexander, Multhaupt‐Buell, Trisha, Pantelyat, Alexander, Pirio Richardson, Sarah E., Raymond, Deborah, Reich, Stephen G., Saunders Pullman, Rachel, Schormair, Barbara, Sharma, Nutan, Sichani, Azadeh Hamzehei, Simonyan, Kristina, Volkmann, Jens, Wagle Shukla, Aparna, Winkelmann, Juliane, Wright, Laura J., Zech, Michael, Zeuner, Kirsten E., Zittel, Simone, Kasten, Meike, Sun, Yan V., Bäumer, Tobias, Brüggemann, Norbert, Ozelius, Laurie J., Jinnah, Hyder A., Klein, Christine, König, Inke R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult age at onset case–control clinical score Dystonia Dystonia - genetics Dystonic Disorders - genetics Female Genetic Predisposition to Disease - genetics Genome-Wide Association Study Genomes GWAS Heritability Humans isolated dystonia Male Middle Aged Movement disorders Nucleotide sequence Polymorphism, Single Nucleotide - genetics Risk Factors Somatic chromosomes Whole genome sequencing
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