Identification of AS1842856 as a novel small‐molecule GSK3α/β inhibitor against Tauopathy by accelerating GSK3α/β exocytosis

Glycogen synthase kinase‐3α/β (GSK3α/β) is a critical kinase for Tau hyperphosphorylation which contributes to neurodegeneration. Despite the termination of clinical trials for GSK3α/β inhibitors in Alzheimer's disease (AD) treatment, there is a pressing need for novel therapeutic strategies ta...

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Veröffentlicht in:	Aging cell 2025-01, Vol.24 (1), p.e14336-n/a
Hauptverfasser:	He, Da‐Long, Zhang, Xiao‐Yu, Su, Jing‐Yang, Zhang, Qi, Zhao, Ling‐Xiao, Wu, Ting‐Yao, Ren, Hang, Jia, Rong‐Jun, Lei, Xian‐Fang, Hou, Wen‐Jia, Sun, Wen‐Ge, Fan, Yong‐Gang, Wang, Zhan‐You
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals AS1842856 Blood-brain barrier Clinical trials Cognitive ability Cyclin-dependent kinases Diabetes Enzyme inhibitors Ethics Exocytosis Exocytosis - drug effects Forkhead protein FOXO1 protein Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta - antagonists & inhibitors Glycogen Synthase Kinase 3 beta - metabolism glycogen synthase kinase‐3α/β Humans Interferometry Intracellular Kinases Laboratory animals Ligands Medical laboratories Mice Mice, Transgenic Neurodegenerative diseases Neuroimaging Okadaic acid Pathology Phosphatase Phosphorylation Phosphorylation - drug effects Physiology Proteins Solvents Tau hyperphosphorylation Tau protein tau Proteins - metabolism Tauopathies - drug therapy Tauopathies - metabolism Transgenic animals Transgenic mice Tumor necrosis factor-TNF
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