A microscopic oxygen transport model for ultra‐high dose rate radiotherapy in vivo: The impact of physiological conditions on FLASH effect

Background Ultra‐high dose rate irradiation (≥40 Gy/s, FLASH) has been shown to reduce normal tissue toxicity, while maintaining tumor control compared to conventional dose‐rate radiotherapy. The radiolytic oxygen (O2) depletion (ROD) resulting from FLASH has been proposed to explain the normal tiss...

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Veröffentlicht in:	Medical physics (Lancaster) 2024-11, Vol.51 (11), p.8623-8637
Hauptverfasser:	Guo, Lixiang, Medin, Paul M., Wang, Ken Kang‐Hsin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport - radiation effects computational model FLASH radiotherapy Models, Biological Oxygen - metabolism Oxygen Consumption - radiation effects oxygen model Radiotherapy - methods Radiotherapy Dosage ultra‐high dose rate
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