Tivozanib plus nivolumab versus tivozanib monotherapy in patients with renal cell carcinoma following an immune checkpoint inhibitor: results of the phase 3 TiNivo-2 Study

Immune checkpoint inhibitors (ICIs) and vascular endothelial growth factor receptor tyrosine kinase inhibitors are cornerstones of first-line treatment for advanced renal cell carcinoma; however, optimal treatment sequencing after progression is unknown. This study aimed to assess clinical outcomes...

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Veröffentlicht in:	The Lancet (British edition) 2024-10, Vol.404 (10460), p.1309-1320
Hauptverfasser:	Choueiri, Toni K, Albiges, Laurence, Barthélémy, Philippe, Iacovelli, Roberto, Emambux, Sheik, Molina-Cerrillo, Javier, Garmezy, Benjamin, Barata, Pedro, Basu, Arnab, Bourlon, Maria T, Moon, Helen, Ratta, Raffaele, McKay, Rana R, Chehrazi-Raffle, Alexander, Hammers, Hans, Heng, Daniel Y C, Braendle, Edgar, Beckermann, Kathryn E, McGregor, Bradley A, Motzer, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Renal Cell - drug therapy Cell death Combination therapy Drug dosages Effectiveness FDA approval Female Growth factors Health services Humans Hypertension Immune checkpoint inhibitors Immune Checkpoint Inhibitors - administration & dosage Immune Checkpoint Inhibitors - adverse effects Immune Checkpoint Inhibitors - therapeutic use Immunotherapy Inhibitors Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - pathology Kinases Ligands Male Metastases Metastasis Middle Aged Monoclonal antibodies Nivolumab - administration & dosage Nivolumab - adverse effects Nivolumab - therapeutic use Oncology Patients Phenylurea Compounds - administration & dosage Phenylurea Compounds - adverse effects Phenylurea Compounds - therapeutic use Population studies Progression-Free Survival Protein-tyrosine kinase receptors Quinolines - administration & dosage Quinolines - therapeutic use Radiology Randomization Renal cell carcinoma Targeted cancer therapy Therapy Tyrosine Vascular endothelial growth factor
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