Baicalein induces apoptosis by targeting ribosomes in Candida auris

The emergence of the “super fungus” Candida auris poses a significant threat to human health, given its multidrug resistance and high mortality rates. Therefore, developing a new antifungal strategy is necessary. Our previous research showed that Baicalein (BE), a key bioactive compound from the dri...

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Veröffentlicht in:	Archives of microbiology 2024-10, Vol.206 (10), p.404, Article 404
Hauptverfasser:	Li, Can, Wang, Jun, Wu, Hui, Zang, Long, Qiu, Wei, Wei, Wenfan, Wang, Tianming, Wang, Changzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Antifungal activity Antifungal agents Antifungal Agents - pharmacology Apoptosis Apoptosis - drug effects Assaying Bioactive compounds Biochemistry Biomedical and Life Sciences Biotechnology Candida - drug effects Candida auris Cell Biology Cell walls Deoxyribonucleic acid DNA DNA fragmentation DNA Fragmentation - drug effects Ecology Flavanones - pharmacology Fluorescent indicators Fungi Fungicides Humans Life Sciences Membrane potential Membrane Potential, Mitochondrial - drug effects Membranes Microbial Ecology Microbial Sensitivity Tests Microbiology Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Multidrug resistance Original Paper Oxygen probes Phosphatidylserine Polymerase chain reaction Reactive oxygen species Reactive Oxygen Species - metabolism Reagents Reverse transcription Ribonucleic acid Ribosomes Ribosomes - drug effects Ribosomes - metabolism RNA Scanning electron microscopy Singlet oxygen Transcriptomics
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