Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis
Background Deep Brain Stimulation (DBS) is FDA-approved for several movement disorders; such as Parkinson's disease, dystonia, and neuropsychiatric disorders. There are various reports of Body mass index (BMI) changes following different DBS targets in various disorders. Aim A comprehensive sys...
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| Veröffentlicht in: | Neurosurgical review 2024-09, Vol.47 (1), p.620, Article 620 |
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| creator | Bahadori, Amir Reza Javadnia, Parisa Dahaghin, Saba Mobader Sani, Sheida Mashaknejadian Behbahani, Fatemeh Imeni Kashan, Azadeh Davari, Afshan Sheikhvatan, Mehrdad Tafakhori, Abbas Shafiee, Sajad Ranji, Sara |
| description | Background
Deep Brain Stimulation (DBS) is FDA-approved for several movement disorders; such as Parkinson's disease, dystonia, and neuropsychiatric disorders. There are various reports of Body mass index (BMI) changes following different DBS targets in various disorders.
Aim
A comprehensive systematic review and meta-analysis were conducted to investigate the impact of DBS on patients' Body Mass Index (BMI) and provide an in-depth overview of its underlying mechanisms.
Materials and Methods
We conducted research according to PRISMA guidelines. Our study assessed comprehensively electronic databases, including Pubmed, Scopus, Embase, web of science, and the Cochrane Library, up to May 2024. The random-effect model analysis was performed by the
Comprehensive Meta-analysis software
(CMA) version 3.0. As well, Cochran’s Q test was used to determine the statistical heterogeneity of included studies.
Result
This systematic review ultimately included 49 studies, 46 of which entered the meta-analysis. The total number of patients was 1478, consisting of Parkinson's disease (PD), dystonia, and the obsessive compulsive disorder (OCD) patients. The most common DBS target was subthalamic nucleus, followed by globus pallidus internus (GPi). Our meta-analysis depicted the BMI of participants significantly mount after DBS electrode implantation (SMD = -0.542, 95%CI: -0.678 to -0.406, and P-value |
| doi_str_mv | 10.1007/s10143-024-02843-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3106044170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3106044170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-9f6b0c02483966fdec1687a11a79cfe100dc3d4f862c6a10b25996b151999313</originalsourceid><addsrcrecordid>eNp9kE1PwzAMhiME4mPwBzigHLkU8tG1DTeExoc0icvuUZo60KltStxu9N8TGCBOSI5s2a9fxQ8h55xdccbya-SMpzJhIo2viNV2jxzHTp4IKdj-n_qInCCuGeO5YvyQHEklCpmy-TF5XTgHdqDe0Qqgp2UwdUdxqNuxMUPtOxqj9zj4HkJsbICWvppoaxBp3VXwfkNvKU44QBvHlgbY1LClpqtoC4NJTGeaCWs8JQfONAhn33lGVveL1d1jsnx-eLq7XSZWiGJIlMtKZuNJhVRZ5iqwPCtyw7nJlXUQ766srFJXZMJmhrNSzJXKSj7nSinJ5Yxc7mz74N9GwEG3NVpoGtOBH1FLzjKWpjxnUSp2Uhs8YgCn-1C3JkyaM_0JWO8A6_gb_QVYb-PSxbf_WLZQ_a78EI0CuRNgHHUvEPTajyFCwP9sPwAFT4cg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3106044170</pqid></control><display><type>article</type><title>Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Bahadori, Amir Reza ; Javadnia, Parisa ; Dahaghin, Saba ; Mobader Sani, Sheida ; Mashaknejadian Behbahani, Fatemeh ; Imeni Kashan, Azadeh ; Davari, Afshan ; Sheikhvatan, Mehrdad ; Tafakhori, Abbas ; Shafiee, Sajad ; Ranji, Sara</creator><creatorcontrib>Bahadori, Amir Reza ; Javadnia, Parisa ; Dahaghin, Saba ; Mobader Sani, Sheida ; Mashaknejadian Behbahani, Fatemeh ; Imeni Kashan, Azadeh ; Davari, Afshan ; Sheikhvatan, Mehrdad ; Tafakhori, Abbas ; Shafiee, Sajad ; Ranji, Sara</creatorcontrib><description>Background
Deep Brain Stimulation (DBS) is FDA-approved for several movement disorders; such as Parkinson's disease, dystonia, and neuropsychiatric disorders. There are various reports of Body mass index (BMI) changes following different DBS targets in various disorders.
Aim
A comprehensive systematic review and meta-analysis were conducted to investigate the impact of DBS on patients' Body Mass Index (BMI) and provide an in-depth overview of its underlying mechanisms.
Materials and Methods
We conducted research according to PRISMA guidelines. Our study assessed comprehensively electronic databases, including Pubmed, Scopus, Embase, web of science, and the Cochrane Library, up to May 2024. The random-effect model analysis was performed by the
Comprehensive Meta-analysis software
(CMA) version 3.0. As well, Cochran’s Q test was used to determine the statistical heterogeneity of included studies.
Result
This systematic review ultimately included 49 studies, 46 of which entered the meta-analysis. The total number of patients was 1478, consisting of Parkinson's disease (PD), dystonia, and the obsessive compulsive disorder (OCD) patients. The most common DBS target was subthalamic nucleus, followed by globus pallidus internus (GPi). Our meta-analysis depicted the BMI of participants significantly mount after DBS electrode implantation (SMD = -0.542, 95%CI: -0.678 to -0.406, and P-value < 0.001). However, moderate to high heterogeneity was detected among the studies (I
2
= 67.566%). Additionally, the Daily energy intake (DEI) of patients significantly decreased after DBS (SMD: 0.457, 95%CI; 0.205 to 0.709, and P-value < 0.001).
Conclusion
STN and GPi DBS can lead to weight gain through distinct central pathways in various movement and neuropsychiatric disorders, posing a potential risk for obesity, insulin resistance, and metabolic syndrome.</description><identifier>ISSN: 1437-2320</identifier><identifier>EISSN: 1437-2320</identifier><identifier>DOI: 10.1007/s10143-024-02843-w</identifier><identifier>PMID: 39283405</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Body Mass Index ; Deep Brain Stimulation - methods ; Dystonia - therapy ; Globus Pallidus ; Humans ; Medicine ; Medicine & Public Health ; Neurosurgery ; Obsessive-Compulsive Disorder - therapy ; Parkinson Disease - therapy ; Review ; Subthalamic Nucleus - surgery</subject><ispartof>Neurosurgical review, 2024-09, Vol.47 (1), p.620, Article 620</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-9f6b0c02483966fdec1687a11a79cfe100dc3d4f862c6a10b25996b151999313</cites><orcidid>0000-0001-8138-1172</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10143-024-02843-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10143-024-02843-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39283405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahadori, Amir Reza</creatorcontrib><creatorcontrib>Javadnia, Parisa</creatorcontrib><creatorcontrib>Dahaghin, Saba</creatorcontrib><creatorcontrib>Mobader Sani, Sheida</creatorcontrib><creatorcontrib>Mashaknejadian Behbahani, Fatemeh</creatorcontrib><creatorcontrib>Imeni Kashan, Azadeh</creatorcontrib><creatorcontrib>Davari, Afshan</creatorcontrib><creatorcontrib>Sheikhvatan, Mehrdad</creatorcontrib><creatorcontrib>Tafakhori, Abbas</creatorcontrib><creatorcontrib>Shafiee, Sajad</creatorcontrib><creatorcontrib>Ranji, Sara</creatorcontrib><title>Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis</title><title>Neurosurgical review</title><addtitle>Neurosurg Rev</addtitle><addtitle>Neurosurg Rev</addtitle><description>Background
Deep Brain Stimulation (DBS) is FDA-approved for several movement disorders; such as Parkinson's disease, dystonia, and neuropsychiatric disorders. There are various reports of Body mass index (BMI) changes following different DBS targets in various disorders.
Aim
A comprehensive systematic review and meta-analysis were conducted to investigate the impact of DBS on patients' Body Mass Index (BMI) and provide an in-depth overview of its underlying mechanisms.
Materials and Methods
We conducted research according to PRISMA guidelines. Our study assessed comprehensively electronic databases, including Pubmed, Scopus, Embase, web of science, and the Cochrane Library, up to May 2024. The random-effect model analysis was performed by the
Comprehensive Meta-analysis software
(CMA) version 3.0. As well, Cochran’s Q test was used to determine the statistical heterogeneity of included studies.
Result
This systematic review ultimately included 49 studies, 46 of which entered the meta-analysis. The total number of patients was 1478, consisting of Parkinson's disease (PD), dystonia, and the obsessive compulsive disorder (OCD) patients. The most common DBS target was subthalamic nucleus, followed by globus pallidus internus (GPi). Our meta-analysis depicted the BMI of participants significantly mount after DBS electrode implantation (SMD = -0.542, 95%CI: -0.678 to -0.406, and P-value < 0.001). However, moderate to high heterogeneity was detected among the studies (I
2
= 67.566%). Additionally, the Daily energy intake (DEI) of patients significantly decreased after DBS (SMD: 0.457, 95%CI; 0.205 to 0.709, and P-value < 0.001).
Conclusion
STN and GPi DBS can lead to weight gain through distinct central pathways in various movement and neuropsychiatric disorders, posing a potential risk for obesity, insulin resistance, and metabolic syndrome.</description><subject>Body Mass Index</subject><subject>Deep Brain Stimulation - methods</subject><subject>Dystonia - therapy</subject><subject>Globus Pallidus</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Obsessive-Compulsive Disorder - therapy</subject><subject>Parkinson Disease - therapy</subject><subject>Review</subject><subject>Subthalamic Nucleus - surgery</subject><issn>1437-2320</issn><issn>1437-2320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiME4mPwBzigHLkU8tG1DTeExoc0icvuUZo60KltStxu9N8TGCBOSI5s2a9fxQ8h55xdccbya-SMpzJhIo2viNV2jxzHTp4IKdj-n_qInCCuGeO5YvyQHEklCpmy-TF5XTgHdqDe0Qqgp2UwdUdxqNuxMUPtOxqj9zj4HkJsbICWvppoaxBp3VXwfkNvKU44QBvHlgbY1LClpqtoC4NJTGeaCWs8JQfONAhn33lGVveL1d1jsnx-eLq7XSZWiGJIlMtKZuNJhVRZ5iqwPCtyw7nJlXUQ766srFJXZMJmhrNSzJXKSj7nSinJ5Yxc7mz74N9GwEG3NVpoGtOBH1FLzjKWpjxnUSp2Uhs8YgCn-1C3JkyaM_0JWO8A6_gb_QVYb-PSxbf_WLZQ_a78EI0CuRNgHHUvEPTajyFCwP9sPwAFT4cg</recordid><startdate>20240916</startdate><enddate>20240916</enddate><creator>Bahadori, Amir Reza</creator><creator>Javadnia, Parisa</creator><creator>Dahaghin, Saba</creator><creator>Mobader Sani, Sheida</creator><creator>Mashaknejadian Behbahani, Fatemeh</creator><creator>Imeni Kashan, Azadeh</creator><creator>Davari, Afshan</creator><creator>Sheikhvatan, Mehrdad</creator><creator>Tafakhori, Abbas</creator><creator>Shafiee, Sajad</creator><creator>Ranji, Sara</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8138-1172</orcidid></search><sort><creationdate>20240916</creationdate><title>Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis</title><author>Bahadori, Amir Reza ; Javadnia, Parisa ; Dahaghin, Saba ; Mobader Sani, Sheida ; Mashaknejadian Behbahani, Fatemeh ; Imeni Kashan, Azadeh ; Davari, Afshan ; Sheikhvatan, Mehrdad ; Tafakhori, Abbas ; Shafiee, Sajad ; Ranji, Sara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-9f6b0c02483966fdec1687a11a79cfe100dc3d4f862c6a10b25996b151999313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Body Mass Index</topic><topic>Deep Brain Stimulation - methods</topic><topic>Dystonia - therapy</topic><topic>Globus Pallidus</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Obsessive-Compulsive Disorder - therapy</topic><topic>Parkinson Disease - therapy</topic><topic>Review</topic><topic>Subthalamic Nucleus - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahadori, Amir Reza</creatorcontrib><creatorcontrib>Javadnia, Parisa</creatorcontrib><creatorcontrib>Dahaghin, Saba</creatorcontrib><creatorcontrib>Mobader Sani, Sheida</creatorcontrib><creatorcontrib>Mashaknejadian Behbahani, Fatemeh</creatorcontrib><creatorcontrib>Imeni Kashan, Azadeh</creatorcontrib><creatorcontrib>Davari, Afshan</creatorcontrib><creatorcontrib>Sheikhvatan, Mehrdad</creatorcontrib><creatorcontrib>Tafakhori, Abbas</creatorcontrib><creatorcontrib>Shafiee, Sajad</creatorcontrib><creatorcontrib>Ranji, Sara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurosurgical review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahadori, Amir Reza</au><au>Javadnia, Parisa</au><au>Dahaghin, Saba</au><au>Mobader Sani, Sheida</au><au>Mashaknejadian Behbahani, Fatemeh</au><au>Imeni Kashan, Azadeh</au><au>Davari, Afshan</au><au>Sheikhvatan, Mehrdad</au><au>Tafakhori, Abbas</au><au>Shafiee, Sajad</au><au>Ranji, Sara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis</atitle><jtitle>Neurosurgical review</jtitle><stitle>Neurosurg Rev</stitle><addtitle>Neurosurg Rev</addtitle><date>2024-09-16</date><risdate>2024</risdate><volume>47</volume><issue>1</issue><spage>620</spage><pages>620-</pages><artnum>620</artnum><issn>1437-2320</issn><eissn>1437-2320</eissn><abstract>Background
Deep Brain Stimulation (DBS) is FDA-approved for several movement disorders; such as Parkinson's disease, dystonia, and neuropsychiatric disorders. There are various reports of Body mass index (BMI) changes following different DBS targets in various disorders.
Aim
A comprehensive systematic review and meta-analysis were conducted to investigate the impact of DBS on patients' Body Mass Index (BMI) and provide an in-depth overview of its underlying mechanisms.
Materials and Methods
We conducted research according to PRISMA guidelines. Our study assessed comprehensively electronic databases, including Pubmed, Scopus, Embase, web of science, and the Cochrane Library, up to May 2024. The random-effect model analysis was performed by the
Comprehensive Meta-analysis software
(CMA) version 3.0. As well, Cochran’s Q test was used to determine the statistical heterogeneity of included studies.
Result
This systematic review ultimately included 49 studies, 46 of which entered the meta-analysis. The total number of patients was 1478, consisting of Parkinson's disease (PD), dystonia, and the obsessive compulsive disorder (OCD) patients. The most common DBS target was subthalamic nucleus, followed by globus pallidus internus (GPi). Our meta-analysis depicted the BMI of participants significantly mount after DBS electrode implantation (SMD = -0.542, 95%CI: -0.678 to -0.406, and P-value < 0.001). However, moderate to high heterogeneity was detected among the studies (I
2
= 67.566%). Additionally, the Daily energy intake (DEI) of patients significantly decreased after DBS (SMD: 0.457, 95%CI; 0.205 to 0.709, and P-value < 0.001).
Conclusion
STN and GPi DBS can lead to weight gain through distinct central pathways in various movement and neuropsychiatric disorders, posing a potential risk for obesity, insulin resistance, and metabolic syndrome.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39283405</pmid><doi>10.1007/s10143-024-02843-w</doi><orcidid>https://orcid.org/0000-0001-8138-1172</orcidid></addata></record> |
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| ispartof | Neurosurgical review, 2024-09, Vol.47 (1), p.620, Article 620 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Body Mass Index Deep Brain Stimulation - methods Dystonia - therapy Globus Pallidus Humans Medicine Medicine & Public Health Neurosurgery Obsessive-Compulsive Disorder - therapy Parkinson Disease - therapy Review Subthalamic Nucleus - surgery |
| title | Effect of deep brain stimulation on postoperative body mass index: A systematic review and meta-analysis |
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