Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal

Major depressive disorder (MDD) is the leading cause of disability globally, with moderate heritability and well-established socio-environmental risk factors. Genetic studies have been mostly restricted to European settings, with polygenic scores (PGS) demonstrating low portability across diverse gl...

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Veröffentlicht in:	Psychological medicine 2024-08, Vol.54 (11), p.1-3134
Hauptverfasser:	Choi, Karmel W, Tubbs, Justin D, Lee, Younga H, He, Yixuan, Tsuo, Kristin, Yohannes, Mary T, Nkambule, Lethukuthula L, Madsen, Emily, Ghimire, Dirgha J, Hermosilla, Sabrina, Ge, Tian, Martin, Alicia R, Axinn, William G, Smoller, Jordan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Childhood Children Depressive personality disorders Environmental aspects Environmental factors Ethnicity Families & family life Genetic analysis Genetic diversity Genomes Genomics Genotyping Heritability Mental depression Minority & ethnic groups Phenotypes Phenotyping Population genetics Population studies Quality control Risk factors Sociodemographics Translation Traumatic life events Variants
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