Magnetic nanoparticles and possible synergies with cold atmospheric plasma for cancer treatment
The biomedical applications of magnetic nanoparticles (MNPs) have gained increasing attention due to their unique biological, chemical, and magnetic properties such as biocompatibility, chemical stability, and high magnetic susceptibility. However, several critical issues still remain that have sign...
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| Veröffentlicht in: | RSC advances 2024-09, Vol.14 (4), p.2939-2951 |
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| creator | Dai, Xiaofeng Dai, Yilin Zheng, Yan Lv, Yi |
| description | The biomedical applications of magnetic nanoparticles (MNPs) have gained increasing attention due to their unique biological, chemical, and magnetic properties such as biocompatibility, chemical stability, and high magnetic susceptibility. However, several critical issues still remain that have significantly halted the clinical translation of these nanomaterials such as the relatively low therapeutic efficacy, hyperthermia resistance, and biosafety concerns. To identify innovative approaches possibly creating synergies with MNPs to resolve or mitigate these problems, we delineated the anti-cancer properties of MNPs and their existing onco-therapeutic portfolios, based on which we proposed cold atmospheric plasma (CAP) to be a possible synergizer of MNPs by enhancing free radical generation, reducing hyperthermia resistance, preventing MNP aggregation, and functioning as an innovative magnetic and light source for magnetothermal- and photo-therapies. Our insights on the possible facilitating role of CAP in translating MNPs for biomedical use may inspire fresh research directions that, once actualized, gain mutual benefits from both.
The biomedical applications of magnetic nanoparticles (MNPs) have gained increasing attention due to their unique biological, chemical, and magnetic properties such as biocompatibility, chemical stability, and high magnetic susceptibility. |
| doi_str_mv | 10.1039/d4ra03837a |
| format | Article |
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The biomedical applications of magnetic nanoparticles (MNPs) have gained increasing attention due to their unique biological, chemical, and magnetic properties such as biocompatibility, chemical stability, and high magnetic susceptibility.</description><subject>Biocompatibility</subject><subject>Biological properties</subject><subject>Biomedical materials</subject><subject>Chemistry</subject><subject>Cold treatment</subject><subject>Free radicals</subject><subject>Hyperthermia</subject><subject>Light sources</subject><subject>Low temperature resistance</subject><subject>Magnetic permeability</subject><subject>Magnetic properties</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkd1LHDEUxYNYVNSXvrcEfJHC2ptkNpl5kkX7BUqhtM_hbnJnd2QmmSazFv_7xq7davOSS84vJ_fmMPZawIUA1bz3VUJQtTK4x44kVHomQTf7z-pDdprzHZSl50JqccAOVSPrIqkjZm9xFWjqHA8Y4oiplD1ljsHzMebcLXvi-SFQWnXl-Fc3rbmLvec4DTGPa0rl6thjHpC3MXGHwVHiU6ICUJhO2KsW-0ynT_sx-_Hxw_erz7Obr5--XC1uZk6JepoJqB20c43Og5_rttI1YutVA4hlDimWXhfSazCyNb4hTXJZGU-GjPemVsfscus7bpYDeVeeTtjbMXUDpgcbsbMvldCt7SreWyFUIxoFxeH8ySHFnxvKkx267KjvMVDcZKsEaFCmNrKgZ_-hd3GTQpmvUEJUUIFsCvVuS7lUPjJRu-tGgH3Mzl5X3xZ_slsU-O3z_nfo36QK8GYLpOx26r_w1W8Z-qAQ</recordid><startdate>20240912</startdate><enddate>20240912</enddate><creator>Dai, Xiaofeng</creator><creator>Dai, Yilin</creator><creator>Zheng, Yan</creator><creator>Lv, Yi</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3636-6664</orcidid><orcidid>https://orcid.org/0000-0001-5323-7886</orcidid></search><sort><creationdate>20240912</creationdate><title>Magnetic nanoparticles and possible synergies with cold atmospheric plasma for cancer treatment</title><author>Dai, Xiaofeng ; Dai, Yilin ; Zheng, Yan ; Lv, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-108c0f56acd0d56f468aafd390aa04621bd6c31d6072f7d9e6e2b47de7e7dd783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biocompatibility</topic><topic>Biological properties</topic><topic>Biomedical materials</topic><topic>Chemistry</topic><topic>Cold treatment</topic><topic>Free radicals</topic><topic>Hyperthermia</topic><topic>Light sources</topic><topic>Low temperature resistance</topic><topic>Magnetic permeability</topic><topic>Magnetic properties</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dai, Xiaofeng</creatorcontrib><creatorcontrib>Dai, Yilin</creatorcontrib><creatorcontrib>Zheng, Yan</creatorcontrib><creatorcontrib>Lv, Yi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dai, Xiaofeng</au><au>Dai, Yilin</au><au>Zheng, Yan</au><au>Lv, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic nanoparticles and possible synergies with cold atmospheric plasma for cancer treatment</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2024-09-12</date><risdate>2024</risdate><volume>14</volume><issue>4</issue><spage>2939</spage><epage>2951</epage><pages>2939-2951</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>The biomedical applications of magnetic nanoparticles (MNPs) have gained increasing attention due to their unique biological, chemical, and magnetic properties such as biocompatibility, chemical stability, and high magnetic susceptibility. However, several critical issues still remain that have significantly halted the clinical translation of these nanomaterials such as the relatively low therapeutic efficacy, hyperthermia resistance, and biosafety concerns. To identify innovative approaches possibly creating synergies with MNPs to resolve or mitigate these problems, we delineated the anti-cancer properties of MNPs and their existing onco-therapeutic portfolios, based on which we proposed cold atmospheric plasma (CAP) to be a possible synergizer of MNPs by enhancing free radical generation, reducing hyperthermia resistance, preventing MNP aggregation, and functioning as an innovative magnetic and light source for magnetothermal- and photo-therapies. Our insights on the possible facilitating role of CAP in translating MNPs for biomedical use may inspire fresh research directions that, once actualized, gain mutual benefits from both.
The biomedical applications of magnetic nanoparticles (MNPs) have gained increasing attention due to their unique biological, chemical, and magnetic properties such as biocompatibility, chemical stability, and high magnetic susceptibility.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>39282063</pmid><doi>10.1039/d4ra03837a</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-3636-6664</orcidid><orcidid>https://orcid.org/0000-0001-5323-7886</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Biocompatibility Biological properties Biomedical materials Chemistry Cold treatment Free radicals Hyperthermia Light sources Low temperature resistance Magnetic permeability Magnetic properties Nanomaterials Nanoparticles |
| title | Magnetic nanoparticles and possible synergies with cold atmospheric plasma for cancer treatment |
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