Evolving a favorable distribution for mutation effects

Evolving a favorable distribution for mutation effects

Tandem-repeat DNA sequences appear to be singularly capable of yielding abundant repeat-number mutations with a potentially advantageous distribution of fitness effects. Although knowing the rates and relative proportions of deleterious, neutral and beneficial mutations is fundamental for understand...

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Veröffentlicht in:Trends in genetics 2024-10, Vol.40 (10), p.819-821
1. Verfasser: King, David G.
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Sprache:eng
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distribution of fitness effects
evolvability
indirect selection
mutation constraints
tandem repeats
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description Tandem-repeat DNA sequences appear to be singularly capable of yielding abundant repeat-number mutations with a potentially advantageous distribution of fitness effects. Although knowing the rates and relative proportions of deleterious, neutral and beneficial mutations is fundamental for understanding evolvability, analysis of adaptation routinely overlooks small-effect mutations arising in tandem repeats. Tandem-repeat DNA sequences appear to be singularly capable of yielding abundant repeat-number mutations with a potentially advantageous distribution of fitness effects. Although knowing the rates and relative proportions of deleterious, neutral and beneficial mutations are fundamental for understanding evolvability, analysis of adaptation routinely overlooks small-effect mutations arising in tandem repeats.
doi_str_mv 10.1016/j.tig.2024.07.009
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subjects distribution of fitness effects
evolvability
indirect selection
mutation constraints
tandem repeats
title Evolving a favorable distribution for mutation effects
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