Separation of recombinant erythropoietin and human serum albumin without the use of sophisticated equipment

A number of drugs based on recombinant erythropoietin contain human serum albumin as an auxiliary component. The presence of this protein hinders the proper control of the drug quality in accordance with the requirements of regulating agencies. We propose the novel method for separation of recombina...

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Veröffentlicht in:	Analytical biochemistry 2025-01, Vol.696, p.115673, Article 115673
Hauptverfasser:	Zybin, Dmitry I., Klishin, Anatoly A., Orlova, Natalia V., Zyryanov, Dmitry А., Prostyakova, Anna I., Kapustin, Dmitry V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Ion Exchange - methods Erythropoietin Erythropoietin - isolation & purification HPLC Human serum albumin Humans Purification Recombinant Proteins - isolation & purification Separation Serum Albumin - analysis Serum Albumin - chemistry Serum Albumin - isolation & purification
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