Target attainment of beta-lactam antibiotics and ciprofloxacin in critically ill patients and its association with 28-day mortality

This study aims to assess pharmacodynamic target attainment in critically ill patients and identify factors influencing target attainment and mortality outcomes. We analysed data from the DOLPHIN trial. Beta-lactam and ciprofloxacin peak and trough concentration were measured within the first 36 h (...

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Veröffentlicht in:	Journal of critical care 2025-02, Vol.85, p.154904, Article 154904
Hauptverfasser:	Dräger, Sarah, Ewoldt, Tim M.J., Abdulla, Alan, Rietdijk, Wim J.R., Verkaik, Nelianne J., van Vliet, Peter, Purmer, Ilse M., Osthoff, Michael, Koch, Birgit C.P., Endeman, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents beta Lactam Antibiotics beta-lactams beta-Lactams - therapeutic use Ciprofloxacin Ciprofloxacin - therapeutic use Creatinine Critical Illness - mortality Critically ill Drug dosages E coli Epidemiology Female Humans Male Middle Aged Mortality Organ Dysfunction Scores Pathogens Patients Pharmacodynamic target attainment Pharmacodynamics Regression analysis Sepsis Software Therapeutic drug monitoring Toxicity
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