Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets

Major depressive disorder (MDD) is a prevalent mental health condition characterized by persistent feelings of sadness and hopelessness, affecting millions globally. The precise molecular mechanisms underlying MDD remain elusive, necessitating comprehensive investigations. Our study integrates trans...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2024-11, Vol.102 (11), p.1355-1369
Hauptverfasser:	Pan, Yarui, Xiang, Lan, Zhu, Tingting, Wang, Haiyan, Xu, Qi, Liao, Faxue, He, Juan, Wang, Yongquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Astrocytes - metabolism Biomedical and Life Sciences Biomedicine Depressive Disorder, Major - drug therapy Depressive Disorder, Major - metabolism Gene Expression Profiling Genomics Human Genetics Humans Internal Medicine Mental depression Mental disorders Mental health Molecular Medicine Molecular modelling Original Article Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Prediction models Prefrontal cortex Prefrontal Cortex - metabolism Protein Interaction Maps Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Risk assessment Single-Cell Analysis Therapeutic applications Therapeutic targets Transcriptome Transcriptomics
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