The Role of Metal Nanoparticles in the Pathogenesis of Stone Formation

The process of stone formation in the human body remains incompletely understood, which requires clinical and laboratory studies and the formulation of a new endogenous, nanotechnological concept of the mechanism of origin and formation of crystallization centers. Previously, the mechanism of sialol...

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Veröffentlicht in:International journal of molecular sciences 2024-09, Vol.25 (17), p.9609
Hauptverfasser: Labis, Varvara, Gaiduk, Igor, Bazikyan, Ernest, Khmelenin, Dmitry, Zhigalina, Olga, Dyachkova, Irina, Zolotov, Denis, Asadchikov, Victor, Kravtsov, Ivan, Polyakov, Nikita, Solovyev, Andrey, Prusakov, Kirill, Basmanov, Dmitry, Kozlov, Ivan G
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container_issue 17
container_start_page 9609
container_title International journal of molecular sciences
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creator Labis, Varvara
Gaiduk, Igor
Bazikyan, Ernest
Khmelenin, Dmitry
Zhigalina, Olga
Dyachkova, Irina
Zolotov, Denis
Asadchikov, Victor
Kravtsov, Ivan
Polyakov, Nikita
Solovyev, Andrey
Prusakov, Kirill
Basmanov, Dmitry
Kozlov, Ivan G
description The process of stone formation in the human body remains incompletely understood, which requires clinical and laboratory studies and the formulation of a new endogenous, nanotechnological concept of the mechanism of origin and formation of crystallization centers. Previously, the mechanism of sialolithiasis was considered a congenital disease associated with the pathology of the ducts in the structure of the glands themselves. To date, such morphological changes of congenital nature can be considered from the position of the intrauterine formation of endogenous bacterial infections complicated by the migration of antigenic structures initiating the formation of crystallization centers. The present work is devoted to the study of the morphology and composition of stones obtained as a result of surgical interventions for sialolithiasis. Presumably, nanoparticles of metals and other chemical compounds can be structural components of crystallization centers or incorporated into the conditions of chronic endogenous inflammation and the composition of antigenic structures, in complexes with protein and bacterial components. X-ray microtomography, X-ray fluorescence analysis, scanning transmission electron microscopy and microanalysis, mass spectrometry, and Raman spectroscopy were used to study the pathogenesis of stone formation. Immunoglobulins (Igs) of classes A and G, as well as nanoparticles of metals Pb, Fe, Cr, and Mo, were found in the internal structure of the stones. The complex of antigenic structures was an ovoid calcified layered matrix of polyvid microbial biofilms, with the inclusion of metal nanoparticles and chemical elements, as well as immunoglobulins. The obtained results of clinical and laboratory studies allow us to broaden the view on the pathogenesis of stone formation and suggest that the occurrence of the calcification of antigenic structures may be associated with the formation of IgG4-associated disease.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central
subjects Calcification
Chemical elements
Crystal structure
Exocrine glands
Humans
Hydroxyapatite
Immunoglobulin G - immunology
Metal Nanoparticles - chemistry
Nanoparticles
Pathogenesis
Proteins
Salivary Gland Calculi - metabolism
Salivary Gland Calculi - pathology
Scanning electron microscopy
Spectrum analysis
Stone
Toxicity
Transmission electron microscopy
title The Role of Metal Nanoparticles in the Pathogenesis of Stone Formation
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