The Role of Metal Nanoparticles in the Pathogenesis of Stone Formation
The process of stone formation in the human body remains incompletely understood, which requires clinical and laboratory studies and the formulation of a new endogenous, nanotechnological concept of the mechanism of origin and formation of crystallization centers. Previously, the mechanism of sialol...
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creator | Labis, Varvara Gaiduk, Igor Bazikyan, Ernest Khmelenin, Dmitry Zhigalina, Olga Dyachkova, Irina Zolotov, Denis Asadchikov, Victor Kravtsov, Ivan Polyakov, Nikita Solovyev, Andrey Prusakov, Kirill Basmanov, Dmitry Kozlov, Ivan G |
description | The process of stone formation in the human body remains incompletely understood, which requires clinical and laboratory studies and the formulation of a new endogenous, nanotechnological concept of the mechanism of origin and formation of crystallization centers. Previously, the mechanism of sialolithiasis was considered a congenital disease associated with the pathology of the ducts in the structure of the glands themselves. To date, such morphological changes of congenital nature can be considered from the position of the intrauterine formation of endogenous bacterial infections complicated by the migration of antigenic structures initiating the formation of crystallization centers. The present work is devoted to the study of the morphology and composition of stones obtained as a result of surgical interventions for sialolithiasis. Presumably, nanoparticles of metals and other chemical compounds can be structural components of crystallization centers or incorporated into the conditions of chronic endogenous inflammation and the composition of antigenic structures, in complexes with protein and bacterial components. X-ray microtomography, X-ray fluorescence analysis, scanning transmission electron microscopy and microanalysis, mass spectrometry, and Raman spectroscopy were used to study the pathogenesis of stone formation. Immunoglobulins (Igs) of classes A and G, as well as nanoparticles of metals Pb, Fe, Cr, and Mo, were found in the internal structure of the stones. The complex of antigenic structures was an ovoid calcified layered matrix of polyvid microbial biofilms, with the inclusion of metal nanoparticles and chemical elements, as well as immunoglobulins. The obtained results of clinical and laboratory studies allow us to broaden the view on the pathogenesis of stone formation and suggest that the occurrence of the calcification of antigenic structures may be associated with the formation of IgG4-associated disease. |
doi_str_mv | 10.3390/ijms25179609 |
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Previously, the mechanism of sialolithiasis was considered a congenital disease associated with the pathology of the ducts in the structure of the glands themselves. To date, such morphological changes of congenital nature can be considered from the position of the intrauterine formation of endogenous bacterial infections complicated by the migration of antigenic structures initiating the formation of crystallization centers. The present work is devoted to the study of the morphology and composition of stones obtained as a result of surgical interventions for sialolithiasis. Presumably, nanoparticles of metals and other chemical compounds can be structural components of crystallization centers or incorporated into the conditions of chronic endogenous inflammation and the composition of antigenic structures, in complexes with protein and bacterial components. X-ray microtomography, X-ray fluorescence analysis, scanning transmission electron microscopy and microanalysis, mass spectrometry, and Raman spectroscopy were used to study the pathogenesis of stone formation. Immunoglobulins (Igs) of classes A and G, as well as nanoparticles of metals Pb, Fe, Cr, and Mo, were found in the internal structure of the stones. The complex of antigenic structures was an ovoid calcified layered matrix of polyvid microbial biofilms, with the inclusion of metal nanoparticles and chemical elements, as well as immunoglobulins. The obtained results of clinical and laboratory studies allow us to broaden the view on the pathogenesis of stone formation and suggest that the occurrence of the calcification of antigenic structures may be associated with the formation of IgG4-associated disease.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25179609</identifier><identifier>PMID: 39273555</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Calcification ; Chemical elements ; Crystal structure ; Exocrine glands ; Humans ; Hydroxyapatite ; Immunoglobulin G - immunology ; Metal Nanoparticles - chemistry ; Nanoparticles ; Pathogenesis ; Proteins ; Salivary Gland Calculi - metabolism ; Salivary Gland Calculi - pathology ; Scanning electron microscopy ; Spectrum analysis ; Stone ; Toxicity ; Transmission electron microscopy</subject><ispartof>International journal of molecular sciences, 2024-09, Vol.25 (17), p.9609</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Previously, the mechanism of sialolithiasis was considered a congenital disease associated with the pathology of the ducts in the structure of the glands themselves. To date, such morphological changes of congenital nature can be considered from the position of the intrauterine formation of endogenous bacterial infections complicated by the migration of antigenic structures initiating the formation of crystallization centers. The present work is devoted to the study of the morphology and composition of stones obtained as a result of surgical interventions for sialolithiasis. Presumably, nanoparticles of metals and other chemical compounds can be structural components of crystallization centers or incorporated into the conditions of chronic endogenous inflammation and the composition of antigenic structures, in complexes with protein and bacterial components. X-ray microtomography, X-ray fluorescence analysis, scanning transmission electron microscopy and microanalysis, mass spectrometry, and Raman spectroscopy were used to study the pathogenesis of stone formation. Immunoglobulins (Igs) of classes A and G, as well as nanoparticles of metals Pb, Fe, Cr, and Mo, were found in the internal structure of the stones. The complex of antigenic structures was an ovoid calcified layered matrix of polyvid microbial biofilms, with the inclusion of metal nanoparticles and chemical elements, as well as immunoglobulins. The obtained results of clinical and laboratory studies allow us to broaden the view on the pathogenesis of stone formation and suggest that the occurrence of the calcification of antigenic structures may be associated with the formation of IgG4-associated disease.</description><subject>Calcification</subject><subject>Chemical elements</subject><subject>Crystal structure</subject><subject>Exocrine glands</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Immunoglobulin G - immunology</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Nanoparticles</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>Salivary Gland Calculi - metabolism</subject><subject>Salivary Gland Calculi - pathology</subject><subject>Scanning electron microscopy</subject><subject>Spectrum analysis</subject><subject>Stone</subject><subject>Toxicity</subject><subject>Transmission electron microscopy</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0DtPwzAUBWALgWgpbMwoEgsDAT-TekQVBaTyUOkeOfYNTZXYxXYG_j0pLahiumf4dHR1EDon-IYxiW_rVRuoILnMsDxAQ8IpTTHO8sO9PEAnIawwpowKeYwGTNKcCSGGaLpYQjJ3DSSuSp4hqiZ5UdatlY-1biAktU1iT95UXLoPsBDqsKHv0VlIps63KtbOnqKjSjUBznZ3hObT-8XkMZ29PjxN7mapppzHtIQy430ETpgpGcdCkqrUOafGVJIbIEyQsZQVGM0Y0TrDGspcG5mVnI3Q1bZ07d1nByEWbR00NI2y4LpQMIK56Ds57enlP7pynbf9az-K4DHHm8LrrdLeheChKta-bpX_KgguNuMW--P2_GJX2pUtmD_8uyb7BrGVdDk</recordid><startdate>20240905</startdate><enddate>20240905</enddate><creator>Labis, Varvara</creator><creator>Gaiduk, Igor</creator><creator>Bazikyan, Ernest</creator><creator>Khmelenin, Dmitry</creator><creator>Zhigalina, Olga</creator><creator>Dyachkova, Irina</creator><creator>Zolotov, Denis</creator><creator>Asadchikov, Victor</creator><creator>Kravtsov, Ivan</creator><creator>Polyakov, Nikita</creator><creator>Solovyev, Andrey</creator><creator>Prusakov, Kirill</creator><creator>Basmanov, Dmitry</creator><creator>Kozlov, Ivan G</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1647-5815</orcidid><orcidid>https://orcid.org/0000-0002-7244-5741</orcidid><orcidid>https://orcid.org/0000-0002-7389-6157</orcidid><orcidid>https://orcid.org/0000-0001-7632-3234</orcidid><orcidid>https://orcid.org/0000-0001-6620-7360</orcidid><orcidid>https://orcid.org/0000-0002-9184-3737</orcidid><orcidid>https://orcid.org/0000-0003-3602-7582</orcidid><orcidid>https://orcid.org/0000-0003-3156-4389</orcidid><orcidid>https://orcid.org/0000-0003-0894-5087</orcidid><orcidid>https://orcid.org/0000-0001-7615-6878</orcidid><orcidid>https://orcid.org/0000-0003-3701-9517</orcidid></search><sort><creationdate>20240905</creationdate><title>The Role of Metal Nanoparticles in the Pathogenesis of Stone Formation</title><author>Labis, Varvara ; Gaiduk, Igor ; Bazikyan, Ernest ; Khmelenin, Dmitry ; Zhigalina, Olga ; Dyachkova, Irina ; Zolotov, Denis ; Asadchikov, Victor ; Kravtsov, Ivan ; Polyakov, Nikita ; Solovyev, Andrey ; Prusakov, Kirill ; Basmanov, Dmitry ; Kozlov, Ivan G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c244t-beb64c24e413db340591fbc742ddf94de1351899fedc331cc60ceb7cd96b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Calcification</topic><topic>Chemical elements</topic><topic>Crystal structure</topic><topic>Exocrine glands</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Immunoglobulin G - 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Previously, the mechanism of sialolithiasis was considered a congenital disease associated with the pathology of the ducts in the structure of the glands themselves. To date, such morphological changes of congenital nature can be considered from the position of the intrauterine formation of endogenous bacterial infections complicated by the migration of antigenic structures initiating the formation of crystallization centers. The present work is devoted to the study of the morphology and composition of stones obtained as a result of surgical interventions for sialolithiasis. Presumably, nanoparticles of metals and other chemical compounds can be structural components of crystallization centers or incorporated into the conditions of chronic endogenous inflammation and the composition of antigenic structures, in complexes with protein and bacterial components. X-ray microtomography, X-ray fluorescence analysis, scanning transmission electron microscopy and microanalysis, mass spectrometry, and Raman spectroscopy were used to study the pathogenesis of stone formation. Immunoglobulins (Igs) of classes A and G, as well as nanoparticles of metals Pb, Fe, Cr, and Mo, were found in the internal structure of the stones. The complex of antigenic structures was an ovoid calcified layered matrix of polyvid microbial biofilms, with the inclusion of metal nanoparticles and chemical elements, as well as immunoglobulins. 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subjects | Calcification Chemical elements Crystal structure Exocrine glands Humans Hydroxyapatite Immunoglobulin G - immunology Metal Nanoparticles - chemistry Nanoparticles Pathogenesis Proteins Salivary Gland Calculi - metabolism Salivary Gland Calculi - pathology Scanning electron microscopy Spectrum analysis Stone Toxicity Transmission electron microscopy |
title | The Role of Metal Nanoparticles in the Pathogenesis of Stone Formation |
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